Funding Opportunities In Us

The purpose of this Funding Opportunity Announcement (FOA) is to solicit R01 research projects utilizing state-of-the-art cancer biology methods and model systems to study effects of different types of radiation used in radionuclide-based therapeutics (e.g., radiopharmaceutical therapy) on normal tissue, tumor cells and the tumor microenvironment.

The purpose of this Notice of Funding Opportunity (NOFO) “Health Home for Children with Medically Complex Conditions” is to award a planning grant for activities related to the development of a section 1945A State Plan Amendments (SPA) for children with medically complex conditions in order to plan and develop their health home model.

Updates (5/2/2024): The Annual Program Statement now does have an overall award ceiling, but rather each Round will have its own award ceiling; Updated the text box on Additional Information on Eligibility; The closing date has been extended by five years, from 9/30/2025 to 9/30/2030; and Updated text in relevant paragraphs of the APS in various Sections. ____________________________________________________ | Original Description (7/12/2019): | The United States Agency for International Development is announcing the New Partnerships Initiative (NPI) Global Health Annual Program Statement (APS) (known hereafter as NPI GH APS). | Through this APS, USAID announces its desire to engage locally-based new and underutilized partners to expand and amplify the Agency’s work in the health sector. The overall Agency NPI seeks to support partner countries’ progress on the Journey to Self-Reliance, achieve sustainable and resilient results, and catalyze more effective partnering for impact.  | This APS is designed to support specific Administration and Agency priorities and criteria for new and underutilized partners (NUPs), especially locally-based NUPs. Individual USAID Missions or Bureaus (also known together as Operating Units) will then request Concept Papers via Rounds as the first step in a three-step process that could result in an award. For the purposes of the NPI Global Health APS, a “Round” is defined as a specific program description that falls under the larger NPI GH APS goal, purpose, and results but is tailored to a certain focus and/or type of new partnership. Interested organizations should read this entire APS, as well as any Rounds, and follow the instructions for submitting a Concept Paper.  | Applicants should not submit Concept Papers in response to this umbrella APS, but only to Rounds published to this APS. USAID reserves the right to fund any or none of the concept papers and applications submitted under this APS and its respective Rounds. USAID reserves the right to close or amend the APS on or before the closing date of September 30, 2025. Therefore, for each issued Round, organizations are encouraged to apply as soon as possible to be considered for review to maximize the possibility of receiving available funding.  Issuance of this APS does not constitute an award or commitment on the part of the USG, nor does it commit the USG to pay for costs incurred in the preparation and submission of a concept paper or an application.  | Pending funding availability, there may be multiple Rounds for this APS that will all aim to meet the Purpose mentioned in Section I. The financial range for award(s) will be specified in each Round.  | As Rounds occur, notifications will be posted on Grants.gov.  Please refer to the specific Round documents for detailed information on the concept paper submission guidance including Round points of contact, concept paper requirements, and evaluation criteria for the specific Round. These Round documents should be located under the "Related Documents" tab in this posting. |

The purpose of the NIDA Animal Genetics Program is to identify genetic, genomic, and molecular (epi)genetic variants that underlie: 1. Phenotypes associated with addictive behaviors and/or vulnerability to distinct stages along the substance use disorders (SUD) trajectory (e.g. initial/acute use, escalation of use, acquisition of tolerance, dependence, uncontrolled use, abstinence and relapse or recovery); 2. Behaviors associated with SUD (e.g. impulsivity, novelty seeking, delayed discounting, and other genetically-associated phenotypes); and 3. Comorbidities that demonstrate genetic correlations with phenotypes and behaviors linked with SUD (e.g. anxiety, stress, poor maternal care, social defeat, and other paradigms). Applications may examine any type of genomic variant, including single nucleotide variants (SNVs), indels, large and small structural variants, and all types of mobile DNA. NIDA encourages applications that take genomics, multi-omics, and/or data-based approaches that integrate multi-level omics data, delineate gene networks, and/or uncover the function of known or newly discovered genetic or epigenetic variants. Other areas of interest include genomics analysis at the circuit level and the application of neuroscience to genomics studies. NIDA expects these studies to uncover novel mechanisms that contribute to various stages across the SUD trajectory and inform future studies about potential targets and therapeutic strategies for addiction.

This Funding Opportunity Announcement (FOA) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling efficient and effective movement of candidate therapeutics or diagnostics towards clinical trials, and to increase their likelihood of success through development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.

The U.S. Embassy in Baghdad invites eligible organizations to submit proposals to implement a project to support and develop committed young environment champions through Ecology Action groups focused on activities in high schools in Baghdad. The program implementer will create Eco Action Clubs or related organized extra curriculum groups at their schools. The implementer will also design the curriculum and the program. The Eco Action Clubs will be supporting student and faculty input in development of ecological activities.   The opportunity will support targeted activities of the Eco Action Clubs to amplify efforts to combat climate change. The programs will serve to promote environmental diplomacy by building champions in climate advocacy for youth as well as youth leadership skills to carry out their initiatives.   The Public Affairs Section of the U.S. Embassy in Baghdad seeks proposals for a project called “Iraqi High School Eco Action Clubs.” The proposed project will consist of establishing and managing Eco Action Clubs in conjunction with six high schools in Baghdad and its surrounding areas. The implementer will identify and develop 60-100 young environmental champions from these school clubs. The implementer will be responsible to the school’s outreach and facilitate the Iraqi Ministry of Education required approvals.   This program will prepare high school students to advocate for environmental reform and raise awareness to protect the environment in Baghdad, the most populated city in Iraq. The program implementer will work with the participating schools to create Eco Action Clubs through volunteerism amongst high school students. The grantee will select 60-100 students targeted school-aged youth with teachers, highlighting and advocating conservation and management of the environment and climate. Specifically, the grantee will work with the participating schools, and the U.S. Embassy will approve venues.

This Funding Opportunity Announcement (FOA) issued by AHRQ invites grant applications for funding to conduct Large Health Services Research Demonstration and Dissemination Projects (R18) that propose to address strategies and approaches for prevention and reduction of Healthcare-Associated Infections (HAIs). This FOA describes the broad areas of HAI research for which funds are available to support Health Services Research Demonstration and Dissemination Projects.

AFOSR plans, coordinates, and executes the Air Force Research Laboratory’s (AFRL) basic research program in response to technical guidance from AFRL and requirements of the Air Force. Additionally, the office fosters, supports, and conducts research within Air Force, university, and industry laboratories; and ensures transition of research results to support U.S. Air Force needs. The focus of AFOSR is on research areas that offer significant and comprehensive benefits to our national war fighting and peacekeeping capabilities. These areas are organized and managed in two scientific Departments: Engineering and Information Science (RTA), Physical and Biological Sciences (RTB), and our international offices (EAORD, SOARD, and AOARD). The research activities managed within each Department are summarized in this section.

Founded in 1984, the Engineering Research Centers (ERC) program brings technology-based industry and universities together in an effort to strengthen the competitive position of American industry in the global marketplace. These partnerships are expected to establish cross-disciplinary centers focused on advancing fundamental engineering knowledge and engineered systems technology while exposing students to the integrative aspects of engineered systems and industrial practice. The goal of the ERC program has traditionally been to integrate engineering research and education with technological innovation to transform and improve national prosperity, health, and security. Building upon this tradition, NSF is interested in supporting ERCs to develop and advance engineered systems, which if successful, will have a high Societal Impact. The ERC program supports convergent research (CR) that will lead to strong societal impact. Each ERC has interacting foundational components that go beyond the research project, including engineering workforce development (EWD) at all participant stages, where all participants gain mutual benefit, and value creation within an innovation ecosystem (IE) that will outlast the lifetime of the ERC. These foundational elements are integrated throughout ERC activities and in alignment with the Center's vision and targeted societal impact. The overall impact of the ERC program is expected within the Engineering Community, the Scientific Enterprise, and Society.

The Naval Research Laboratory (NRL) is the Navy's corporate laboratory. NRL conducts basic and applied research for the Navy in a variety of scientific and technical disciplines. The basic research program is driven by perceptions about future requirements of the Navy.

Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information.   For the addresses for obtaining and submitting an application, please refer to our Revised Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on December 7, 2022.   Purpose of Program: In awarding the research grants, the Institute of Education Sciences (IES) intends to provide national leadership in expanding knowledge and understanding of (1) developmental and school readiness outcomes for infants and toddlers with or at risk for a disability, (2) education outcomes for all learners from early childhood education through postsecondary and adult education, and (3) employment and wage outcomes when relevant (such as for those engaged in career and technical, postsecondary, or adult education). The IES research grant programs are designed to provide interested individuals and the general public with reliable and valid information about education practices that support learning and improve academic achievement and access to education opportunities for all learners. These interested individuals include parents, educators, learners, researchers, and policymakers. In carrying out its grant programs, IES provides support for programs of research in areas of demonstrated national need. In awarding research training grant programs, IES aims to prepare individuals to conduct rigorous and relevant education and special education research that advances knowledge within the field and addresses issues important to education policymakers and practitioners. Competitions in This Notice: IES is announcing four research competitions through two of its centers: The IES National Center for Education Research (NCER) is announcing two competitions in the following areas: education research, and statistical and research methodology in education. The IES National Center for Special Education Research (NCSER) is announcing two competitions—one competition in each of the following areas: special education research, and special education research training. NCER Competitions Education Research Grants Program (ALN 84.305A).  Under this competition, NCER will consider only applications that address one of the following topics: ·      Career and Technical Education. ·      Civics Education and Social Studies. ·      Cognition and Student Learning. ·      Early Learning Programs and Policies. ·      English Learner Policies, Programs, and Practices. ·      Improving Education Systems: Policies, Finance, Organization, Management, and Leadership. ·      Literacy. ·      Postsecondary and Adult Education. ·      Science, Technology, Engineering, and Mathematics (STEM) Education. ·      Social, Emotional, and Behavioral Context for Teaching and Learning. ·      Teaching, Teachers, and the Education Workforce. Statistical and Research Methodology in the Education Sciences (ALN 84.305D). Under this competition, NCER will consider applications that address one of the following topics: ·      Core Grants (which supports the development of new and improved statistical and research methods and their dissemination to education researchers). ·      Toolkits, Guidelines, Compendia, Review Papers, and Curated Data Resources. NCSER Competitions Special Education Research Grants Program (ALN 84.324A). Under this competition, NCSER will consider only applications that address the following topic: ·      Education Systems. Research Training Programs in Special Education (ALN 84.324B). Under this competition, NCSER will consider only applications that address the following topic: ·      Early Career Development and Mentoring. Multiple Submissions: You may submit applications to more than one of the FY 2025 research grant programs offered through the Department, including those offered through IES as well as those offered through other offices and programs within Department. You may submit multiple applications to each IES grant program announced here as long as they address different key issues, programs, or policies.  However, you may submit a given application only once for the IES FY 2025 grant competitions, meaning you may not submit the same application or similar applications to multiple grant programs within IES, to multiple topics within a grant competition, or multiple times within the same topic. If you submit multiple similar applications, IES will determine whether and which applications will be accepted for review and/or will be eligible for funding.  In addition, if you submit the same or similar application to IES and to another funding entity within or external to the Department of Education and receive funding for the non-IES application prior to IES scientific peer review of applications, you must withdraw the same or similar application submitted to IES, or IES may otherwise determine you are ineligible to receive an award. If reviews are happening concurrently, IES staff will consult with the other potential funder to determine the degree of overlap and which entity will provide funding if both applications are being considered for funding. Exemption from Proposed Rulemaking: Under section 191 of the Education Sciences Reform Act, 20 U.S.C. 9581, IES is not subject to section 437(d) of the General Education Provisions Act, 20 U.S.C. 1232(d), and is therefore not required to offer interested parties the opportunity to comment on matters relating to grants. Program Authority: 20 U.S.C. 9501 et seq. Note: Projects will be awarded and must be operated in a manner consistent with the nondiscrimination requirements contained in Federal civil rights laws. Applicable Regulations: (a) The Education Department General Administrative Regulations in 34 CFR parts 77, 81, 82, 84, 86, 97, 98, and 99. In addition, the regulations in 34 CFR part 75 are applicable, except for the provisions in 34 CFR 75.100, 75.101(b), 75.102, 75.103, 75.105, 75.109(a), 75.200, 75.201, 75.209, 75.210, 75.211, 75.217(a)-(c), 75.219, 75.220, 75.221, 75.222, 75.230, and 75.250(a). (b) The Office of Management and Budget Guidelines to Agencies on Governmentwide Debarment and Suspension (Nonprocurement) in 2 CFR part 180, as adopted and amended as regulations of the Department in 2 CFR part 3485. (c) The Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards in 2 CFR part 200, as adopted and amended as regulations of the Department in 2 CFR part 3474. Note: The regulations in 34 CFR part 86 apply to institutions of higher education only.  Note: The open licensing requirement in 2 CFR 3474.20 does not apply to these competitions.       Assistance Listing Number (ALN) 84.324B.   |

Broad Agency Announcement Solicitation for the US Army Combat Capabilities Development Command - Soldier Center (CCDC-SC). Please see the BAA solicitation document for the submission instructions and areas of interest. This posting is not for a specific requirement - only to post the BAA solicitation so that interested parties can submit white papers and proposals for grants and other assistance agreements.

This is a Request for Information (RFI) Notice requesting comments to the draft Program Description (PD) below for the USAID/Senegal, Sahel Regional Office’s (SRO) RISE II Health Services Delivery (HSD) Activity. The purpose of this RFI is to obtain feedback from stakeholders prior to SRO potentially issuing a Notice of Funding Opportunity (NOFO) Announcement. This RFI is not a Request for Application (RFA). Therefore, USAID/Senegal is not accepting applications at this time. Please provide no more than 4 pages of comments no later than June 15, 2018 through email to [email protected]. Responses/comments received from this RFI may be used for planning purposes. Responding to this RFI will not give any advantage to any potential applicant in any subsequent procurement and will not lead to an organizational conflict of interest. You may receive an electronic confirmation acknowledging receipt of your response. USAID will hold a Pre-Solicitation Conference on June 04, 2018 at the U.S. Embassy in Dakar from 12:30 to 15:00 local time (GMT). For convenience, another alternate site for participation through VTC may be provided in the Washington, D.C. area.

The U.S. Department of State Bureau of Economic and Business Affairs (EB) announces an open competition for organizations to submit a statement of interest (SOI) to carry out a program under the International Technology Security and Innovation (ITSI) Fund, created by the CHIPS Act of 2022. Please carefully follow all instructions below.  | The submission of the SOI is the first step in a two-step process. Applicants must first submit a concise no more than three (3) page statement of interest designed to clearly communicate the program idea and objectives. This is not a full proposal. The purpose of the SOI process is to allow applicants to submit program ideas for evaluation prior to requiring the development of a full proposal application. Upon a merit review of eligible SOIs, selected applicants will be invited to expand on their program idea(s) by submitting a full proposal application. Full proposals will go through a second merit review before final funding decisions are made.   | EB administers a portion of the ITSI Fund, the “ITSI Promote” line of effort, to help expand international semiconductor assembly, testing, and packaging (“ATP” or “downstream”) capacity in key partner countries that will in turn diversify the global semiconductor supply chain. EB’s objectives under the ITSI Fund are to: 1) Expand and diversify the required workforce for semiconductor ATP facilities to ensure growth; and 2) Improve regulatory environments that will encourage private sector efforts that generate additional capabilities in ATP facilities.  | This solicitation is specific to Costa Rica and includes two (2) categories under which applicants may submit SOIs: 1) Workforce Development, and 2) Policy and Regulatory Reform. See "Related Documents" tab for attached RSOI background, illustrative activities, and submission instructions. | If you have any questions about the SOI application process, please contact [email protected] by August 2, 2024. Emails must reference the funding opportunity number DFOP0016763 in the subject line. FAQ will be posted on Grants.gov by August 10, 2024. SOIs may be submitted via email to [email protected].

The Defense Security Cooperation Agency’s (DSCA) Defense Security Cooperation University (DSCU) promotes access to and production of knowledge on security cooperation. Security cooperation refers to “all Department of Defense (DoD) interactions with foreign security establishments that build and develop allied and partner security capabilities and capacity for self-defense and multinational operations, provide the Armed Forces of the United States with access to the foreign country during peacetime or a contingency operation, and build relationships that promote specific United States security interests” (Joint Publication 3-20, Security Cooperation, 1-2; see also 10 USC § 16, “Security Cooperation”).  | Evidence-, theory, and data-building activities that contribute to the body of knowledge on security cooperation or irregular warfare, and that result in lessons that can be applied to practice, are the primary focus of this notice of funding opportunity (NFO). Research products sponsored through this NFO must be unclassified and publicly accessible. DSCU expects awardees to participate in conferences, seminars, focus groups and events, and to make final research products and supporting data (if applicable) easily accessible to the public, in order to enhance dissemination of research findings and facilitate application of lessons learned in areas of policy, practice, and workforce professionalization. | The DSCU research grant program, conducted pursuant to 10 USC § 4001 and 10 USC § 384(g), is generally open to a broad range of researchers, although individual DSCU components may have restrictions on who may receive grants. | Please see the full NFO for complete details.

The International Narcotics and Law Enforcement Affairs Section of the U.S. Embassy Kyiv is inviting non-for-profit organizations to submit proposals for programs aimed at providing critical support to Ukraine's law enforcement and criminal justice agencies in their pursuit of investigating, prosecuting and adjudicating war crimes committed by Russian federation and bringing perpetrators of the grave atrocities to accountability. This may include providing expert and mentoring assistance to prosecutors and investigators of Ukraine, offering specialized training modules to enhance their skills in handling complex cases, conducting activities aimed at advancing the rule of law and fair trial in the newly de-occupied territories and increasing society’s awareness about adjudication of the war criminals. The initiative also seeks to foster international cooperation by facilitating partnerships with relevant agencies and organizations, encouraging the exchange of best practices and collaborative strategies in the pursuit of justice. Additionally, the program also seeks assistance in documenting efforts, employing cutting-edge open-source intelligence (OSINT) techniques and IT solutions to gather and analyze information crucial for building strong legal cases. Through these comprehensive activities, the program aims to fortify Ukraine's legal infrastructure, empowering its authorities to pursue accountability for war crimes and uphold the principles of international humanitarian law. All programs should be drafted in close coordination with respective GOU stakeholders.

The GLD Program supports innovative fundamental research into processes that shape and modify earth's landscapes over a variety of length and time scales, with a focus on the Holocene. The program encourages research that quantitatively investigates the coupling and feedback among such processes, their rates, and their relative roles, especially in the contexts of variation in biologic, climatic, and tectonic influences and in light of changes due to human impacts. Such research may involve fieldwork, modeling, experimentation, theoretical development, or combinations thereof. GLD is particularly interested in increasing the participation of underrepresented groups in research and education such as women, persons with disabilities, and underrepresented minorities [1], and those from geographically underrepresented areas in science, technology, engineering, and mathematics (STEM). Proposals submitted in response to this solicitation are strongly encouraged to involve PIs, co-PIs, postdoctoral researchers, students, and other personnel who are members of these groups. Proposers are also strongly encouraged to consider involving veterans of the U.S. Armed Forces as part of NSF’s broader effort to promote veteran involvement in STEM research and education. [1] https://ncses.nsf.gov/pubs/nsf19304/digest/introduction

The Human Networks and Data Science program (HNDS) supports research that enhances understanding of human behavior by leveraging data and network science research across a broad range of topics. HNDS research will identify ways in which dynamic, distributed, or heterogeneous data can provide novel answers to fundamental questions about individual or group behavior. HNDS is especially interested in proposals that provide data-rich insights about human networks to support improved health, prosperity, and security. HNDS has two tracks: (1) Human Networks and Data Science – Infrastructure (HNDS-I). Infrastructure proposals will address the development of data resources and relevant analytic techniques that support fundamental Social, Behavioral and Economic (SBE) research. Successful infrastructure proposals will construct, within the financial resources provided by the award, databases or relevant analytic techniques and produce a finished product that will enable previously impossible data-intensive research in the social sciences. The databases or techniques should have significant impacts, either across multiple fields or within broad disciplinary areas, by making possible new types of data-intensive research in the SBE sciences. (2) Human Networks and Data Science – Core Research (HNDS-R). Core research proposals will advance theory in a core SBE discipline by the application of data and network science methods. This includes the leveraging of large data sets with diverse spatio-temporal scales of measurement and linked qualitative and quantitative approaches, as well as multi-scale, multi-level network data and techniques of network analysis. Supported projects are expected to yield results that will enhance, expand, and transform theory and methods, and that generate novel understandings of human behavior – particularly understandings that can lead to significant societal benefits or opportunities. HNDS-R encourages core research proposals that make innovative use of NSF-supported data networks, databases, centers and other forms of scientific infrastructure including those developed by HNDS-I (formerly RIDIR) projects.

The NSF Research Traineeship (NRT) program seeks proposals that explore ways for graduate students in research-based master’s and doctoral degree programs to develop the skills, knowledge, and competencies needed to pursue a range of STEM careers. The program is dedicated to effective training of STEM graduate students in high priority interdisciplinary or convergent research areas, through a comprehensive traineeship model that is innovative, evidence-based, and aligned with changing workforce and research needs. Proposals are requested that address any interdisciplinary or convergent research theme of national priority, as described in section II.D below. The NRT program addresses workforce development, emphasizing broad participation, and institutional capacity building needs in graduate education. The program encourages proposals that involve strategic collaborations with the private sector, non-governmental organizations (NGOs), government agencies, national laboratories, field stations, teaching and learning centers, informal science centers, and academic partners. NRT especially welcomes proposals that reflect collaborations between NRT proposals and existing NSF Eddie Bernice Johnson Inclusion across the Nation of Communities of Learners of Underrepresented Discoverers in Engineering and Science (INCLUDES) Initiative, Research Experiences for Undergraduates (REU), Louis Stokes Alliances for Minority Participation (LSAMP), NSF Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM), and NSF STEM Ed Organizational Postdoctoral Fellowship program (STEM Ed OPRF) projects, provided the collaboration will strengthen both projects. Researchers at minority serving institutions and emerging research institutions are strongly encouraged to submit proposals. Collaborations between NRT proposals and existing NSF INCLUDES projects should strengthen both NRT and INCLUDES projects.

To address ecological questions that cannot be resolved with short-term observations or experiments, NSF established the Long-Term Ecological Research Program (LTER) in 1980. Two components differentiate LTER research from projects supported by other NSF programs: 1) the research is located at specific sites chosen to represent major ecosystem types or natural biomes, and 2) it emphasizes the study of ecological phenomena over long periods of time based on data collected in five core areas. Ongoing research at LTER sites is expected to contribute to the development and testing of fundamental ecological theories and significantly advance understanding of the long-term dynamics of populations, communities, and ecosystems. It often integrates multiple disciplines and, through cross-site interactions, may examine patterns or processes over broad spatial scales. Recognizing that the value of long-term data extends beyond use at any individual site, NSF requires that data collected by all LTER sites be made publicly accessible in compliance with NSF data requirements. NSF currently supports 27 LTER sites and a network office. The program is on-going and proposals for new LTER sites are periodically invited when a need is identified to balance the LTER portfolio or when funding opportunities arise to support new LTERs. These opportunities are announced through separate solicitations. This solicitation governs submission of renewal proposals for active LTER site awards, not new sites.

The DARPA Tactical Technology Office (TTO) creates technological surprise and provides new options for national security, by demonstrating revolutionary platforms and systems with cutting-edge technology. TTO demonstrates compelling hardware at scales that demonstrate disruptive capability, with designs that reduce risk and cost by managing complexity, and which can be manufactured responsively and affordably. TTO is soliciting innovative executive summaries and proposals that enhance the nation’s ability to rapidly build, adapt and sustain force structures with the following focus areas: Platform Innovation, Missionized Autonomy, Managing Complexity, Freedom’s Forge 2.0, and Disruptive Emergent Technology.

In the near future, USAID/Yemen intends to announce a full and open competition to implement the Mission’s Community Livelihoods Project (CLP) subject to the availability of funds. This integrated, flexible, multi-sectoral initiative will serve as the flagship project for the Mission’s implementation of the 2010-2012 USAID/Yemen Strategy. CLP is not a traditional development initiative, but it will rely heavily on tried and proven as well as innovative tools transition and development environments. The project is intended to mitigate the drivers of instability in some of Yemen’s most difficult areas through the facilitation and implementation of quality government service delivery, job creation, responsive local governance, and active civic participation. Rapidly responding to community-based initiatives to demonstrate USAID’s and the Government of Yemen’s commitment to underserved communities will be a hallmark of this project. Youth under 25 years old, representing 75% of Yemen’s population, will be a particularly important demographic group throughout implementation. Activities will quickly and effectively mitigate critical threats to stability in Yemen by building trust and relationships between communities with historically difficult relations with Yemeni authorities and the citizens in targeted areas. This project will be expected to build on and complement ongoing activities during the transition phase between the existing portfolio of USAID/Yemen projects and this flagship initiative. Very close coordination and collaboration with the Mission’s future National Governance Project (NGP) will be extremely important during the implementation of the CLP. The implementer also will partner with and make extensive use of local, Yemeni organizations during the implementation of the project. The implementer also will coordinate with USAID’s future Monitoring and Evaluation Project to help ensure that program results are tracked against stability measures.USAID/Yemen’s 2010-2012 Strategy will be released when this solicitation is released for bid. USAID anticipates an award for a base period of three years with the potential for follow-on activities dependent on performance and availability of funding. Subject to the availability of funds, the estimated budget for the three year base period is approximately $65 million.Please note that the Mission staff will be unable to entertain meetings or respond to queries with prospective implementers at this stage. For further information, please check the web site www.grants.gov in the near future.

Microbes and communities of microbes have remarkable genetic, physiological and biochemical diversity, allowing them to flourish in environments all over the planet and in a variety of substrates and hosts. Given their relative importance to ecosystems around the world, to the economy and to health, researchers have studied microbial systems extensively and have a better understanding of their capabilities and impacts on hosts and the environment. In recent years, researchers have increasingly turned to microbes and their diverse capabilities for bioremediation and applications in biotechnology, agriculture, and medicine. Because of advances in molecular biology, synthetic biology and bioengineering, researchers now have the ability to assemble synthetic microbial communities that have novel compositions, genetics and phenotypes and to use these communities to address both fundamental biological questions and a range of societal problems. The goal of this solicitation is to support research that addresses one or more of the three themes: 1) define the underlying mechanisms or rules that drive the formation, maintenance or evolution of synthetic microbial communities, 2) use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology and evolution and/or 3) build synthetic communities with biotechnology, bioeconomy or environmental engineering applications, including but not limited to the production of novel biorenewable chemicals, biodegradation of recalcitrant or “forever chemicals,” enabling a circular bioeconomy, fostering sustainable agriculture and mitigating the impacts of climate change. For theme 3, the emphasis should be on designing communities with novel capabilities and understanding the underlying mechanisms that lead to these novel capabilities. Proposals must address one or more of the three themes noted above. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. The most competitive broader impacts include assessment plans. Well-conceived broader impacts activities take time and resources; thus, proposers are encouraged to include appropriate costs for broader impacts in the budget. To better understand the societal benefits and risks, as well as the potential for misuse or unintended damage to natural biological systems, synthetic microbial communities proposals should include a careful consideration of the social, ethical, and biosafety/security dimensions of the research. Investigators may choose to address these issues either as part of intellectual merit or broader impacts. Reproducibility in research leads to data that is amenable to more powerful analysis and the potential for reuse of data and greater generation of knowledge. Reproducibility in biological research that is prone to context dependent biological variation presents a unique challenge for the synthetic microbial communities researchers. Investigators must follow or advance best practices in sample collection and preparation, experimental design, data analysis, model generation, and/or validation of mathematical and computational methods to produce scientifically defensible results.

The U.S. Department of Agriculture, Foreign Agricultural Service, Global Programs, announces this funding opportunity to support the Quality Samples Program by issuing new awards. This opportunity is available to U.S. entities to provide funding for projects that provide commodity samples to potential foreign importers to promote a better understanding and appreciation for the high quality of U.S. agricultural commodities.

Mathematical Sciences Research Institutes are national resources that aim to advance research in the mathematical sciences through programs supporting discovery and dissemination of knowledge in mathematics and statistics and enhancing connections to related fields in which the mathematical sciences can play important roles. Institute activities help focus the attention of some of the best mathematical minds on problems of particular importance and timeliness. Institutes are also community resources that involve a broad segment of U.S.-based mathematical sciences researchers in their activities. The goals of the Mathematical Sciences Research Institutes program include advancing research in the mathematical sciences, increasing the impact of the mathematical sciences in other disciplines, and expanding the talent base engaged in mathematical research in the United States.

The purpose of this Notice of Funding Opportunity (NOFO) is to identify cure strategies suitable for administration at the start of combination antiretroviral therapy (cART) and/or at cART restart after an analytical treatment interruption (ATI), with the ultimate goal of achieving sustained treatment-free remission.

The purpose of this NOFO is to build the evidence base for the prevention of intimate partner violence (IPV), including teen dating violence (TDV), and/or sexual violence (SV), in communities experiencing elevated risk of IPV/SV, including but not limited to racial/ethnic minority groups, sexual and gender minority groups, and people with disabilities. This NOFO seeks proposals to support formative research of primary prevention approaches (i.e., policies programs, or practices). Formative research involves the use of qualitative and quantitative methods to strengthen the components of the prevention approach (e.g., design and implementation, appropriateness, and acceptability), and components of the evaluation activities (e.g., instrument development, implementation evaluation, recruitment, and retention, and pilot studies). This funding opportunity will support formative research that builds capacity for a future rigorous evaluation of the selected primary prevention approach. The prevention approach selected for formative research and pilot study must be community-led, which means the approach was developed with substantial input from communities that face inequitable risk for IPV and/or SV and is being implemented in a community-based setting. IPV and/or SV prevention approaches are strongly encouraged at the community or societal levels, including those that address social determinants of health. Research activities should include at least one element of both the formative evaluation and implementation evaluation. Formative evaluation activities may include but are not limited to using mixed methods for data collection (i.e., quantitative and qualitative methods) to assess the feasibility, appropriateness, and acceptability of the prevention approach. Implementation evaluation activities may include but are not limited to using to using mixed methods to assess the reach, dosage, and fidelity of the prevention approach. All projects are required to conduct a pilot study, also referred to as a pilot test or effectiveness evaluation, to assess the preliminary efficacy or effectiveness of the primary prevention approach by examining changes in IPV and/or SV outcomes.

Abidjan’s Public Diplomacy Section (PDS) program seeks a cooperative agreement with one partner who will oversee a series of speaking engagements on a diverse range of topics. The program will bring together American and Ivoirian experts to engage the public on pressing issues which are priorities for both countries. The program topics will be chosen in tandem with PDS and can include but are not limited to:Coastal protection and climate change,Ethical Uses of Artificial Intelligence (AI)Entrepreneurship: developing and scaling a business across sectorsCivic Engagement: The Future of African Youth: encouraging youth participation 

Department of the Interior - Bureau of Land Management National Operations Center (NOC) Wildlife Resource Management

The National Facilities program supports the operation of national user facilities: National Facilities areresearch facilities with specialized instrumentation available to the scientific research community in general and the materials research community in particular.These facilities provide unique research capabilities that can be located at only a few highly specialized laboratories in the Nation. They provide open user service for scientists and engineers from a broad range of disciplines including biology, chemistry, geosciences, materials research. and physics. Theyinclude facilities and resources for research using high magnetic fields, ultraviolet and x-ray synchrotron radiation, neutron scattering, and nanofabrication. Theyserve as science and technology-related resources and experiences for students. Theyconduct student and teacher education, general public awareness activities, curriculum development, and educational research.

NIST’s mission is to drive innovation and industrial competitiveness through measurement science and standards by cultivating a culture of belonging that integrates diversity, equity, inclusion, and accessibility in all ways of working. One component of this mission is NIST’s ongoing effort to develop a diverse, world-class pool of scientists and engineers to engage in NIST's measurement science and standards research, and to support the development of a general population that understands and appreciates measurement science and standards. NIST also seeks to collaborate with a wide range of organizations, including but not limited to minority-serving institutions such as Historically Black colleges and universities, as well as community colleges, in support of NIST's mission. | This funding opportunity will result in the award of grants or cooperative agreements.

This NOFO seeks proposals aimed at building the evidence base for the primary prevention of intimate partner violence, including teen dating violence, and/or sexual violence. This funding opportunity will support rigorous outcome evaluations of promising practice-based prevention approaches that are currently being implemented by state and/or local organizations that address intimate partner violence and/or sexual violence. This includes, but is not limited to, organizations that receive funding under CDC’s Rape Prevention and Education Program and CDC’s DELTA AHEAD program. By promising practice-based approaches we mean programs, policies, or practices that can demonstrate the following: (a) Evidence of implementation in the field for a minimum of two years; and (b) Collection of prior positive implementation-related outcomes (e.g., data demonstrating reach, fidelity, availability, and/or acceptability of the approach) and/or collection of outcome monitoring data before and after implementing the approach that demonstrate positive changes in relevant outcomes. Research on promising practice-based prevention approaches will evaluate the effectiveness of prevention approaches that already have traction within the field but have not been rigorously evaluated. As a result, this research can build the evidence for approaches that are feasible to implement by practitioners and acceptable to communities. Research aimed at building evidence at the community- or societal-levels is of particular interest under this announcement. In addition, research aimed at building evidence for populations and communities that experience inequitable risk for intimate partner violence and/or sexual violence is of particular interest, including approaches that address social determinants of health. This NOFO covers a four (4) year period of performance to complete a full-scale rigorous evaluation. This research can address critical research gaps and expand the evidence base for effective programs, policies, and practices that prevent intimate partner violence and sexual violence. The availability of a broader range of evidence-based strategies will help address risk and protective factors across all levels of the social ecology. Implementing comprehensive prevention strategies can help move the field towards reductions in intimate partner violence and sexual violence at the population level (DeGue et al., 2012).

University, National Laboratory, Industry, and International Entities Input to the Office of Nuclear Energy’s Competitive Research and Development Work Scope Development - DOE is seeking ideas in the areas of research, information, comments, feedback, and recommendations from interested parties for future work scopes for the major NE-funded research programs. All responses are to be made at NEUP.gov per the attached instructions.

Reissue of RFA-NS-22-011 to comply with DMSP. No additional receipt dates added. This funding opportunity announcement (FOA) supports efforts to disseminate resources and to integrate them into neuroscience research practice. Projects should be highly relevant to specific goals of the BRAIN Initiative, goals that are described in the planning document "BRAIN 2025: A Scientific Vision." They should engage in one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community. Applications strictly focused on technology or software development, rather than dissemination of an existing resource, are not responsive to this FOA. Refinements to microscopes or tools necessary to customize them to the experimental needs of the end users is allowed. Projects should address compelling needs of neuroscience researchers working toward the goals of the BRAIN 2025 report that are otherwise unavailable or impractical in their current form.

The Office of Nuclear Energy (NE) mission is to advance nuclear energy science and technology to meet the United States (U.S.) energy, environmental, and economic needs. NE has identified the following goals to address challenges in the nuclear energy sector, help realize the potential of advanced technology, and leverage the unique role of the government in spurring innovation: • Keep existing U.S. nuclear reactors operating, • Deploy new nuclear reactors, • Secure and sustain our nuclear fuel cycle, and • Expand international nuclear energy cooperation. NE conducts crosscutting nuclear energy research and development (R&D) and associated infrastructure support activities to develop innovative technologies that offer the promise of dramatically improved performance for its mission needs as stated above, while maximizing the impact of NE resources. This Phase II Continuation CINR FOA provides opportunities for teams that have performed high quality work through the Nuclear Energy University Program (NEUP) to propose new projects that complement and enhance ongoing NEUP research through a competitive application and review process. This Phase II Continuation CINR process is executed through NEUP. NEUP supports university-based infrastructure and R&D (including Integrated Research Projects (IRP)) in areas relevant to the NE mission.

With this solicitation, NIJ seeks proposals to examine programs funded by the Bureau of Justice Assistance (BJA) Byrne State Crisis Intervention Program (SCIP) in Fiscal Years (FY) 2022-2024. The BJA Byrne SCIP program provides funding for the implementation and/or creation of specific program areas: (1) extreme risk protection order (ERPO) programs, (2) courts response to people in crisis, (3) community-based services for people in crisis, and (4) funding for law enforcement crisis intervention programs or initiatives. This NIJ solicitation seeks research addressing two categories: (1) scan of practices of state crisis intervention activities including those funded by BJA under the FY 2022-2023 and FY 2024 BJA Byrne SCIP (anticipate one award of up to $600,000); and (2) evaluability assessments for each of the four program areas funded by BJA under the FY 2022-2023 and FY 2024 BJA Byrne SCIP solicitations (anticipate 4 awards of up to $1,500,000 per award). Applicants must clearly indicate the category to which they are responding in the application title. Applicants may submit to more than one category, but must submit a separate, complete application for each category. Within Category 2, applicants may apply to assess programs that cover more than one BJA Byrne SCIP program area, where applicable.

The National Historical Publications and Records Commission seeks applications involving collaborative teams of archivists and other practitioners to address archival capacity building and 2 related challenges in the processing, long-term preservation, discovery, access, and research use of archival collections at Historically Black Colleges and Universities (HBCUs). The Commission seeks applications from collaborative teams involving HBCU-based repositories, libraries, research centers, and/or other archival or community-based archival entities serving to build capacity at HBCUs, working together to advance the capacity and effectiveness of HBCU archives to care for their collections and make them discoverable and accessible to the public and to the broader field of researchers, students, and teachers. The collaborative teams should demonstrate a commitment to building meaningful, mutually-beneficial and respectful collaborations by promoting resource sharing and capacity building at all levels. Collaborative teams also must demonstrate commitment to institutional advancement and capacity-building for small and underserved HBCU archives and repositories, especially those organizations with missions to serve a collective of HBCUs; strengthen the archival ecosystem that supports HBCU collections and history; and/or service similar organizations that preserve collections that document African American or other marginalized histories. Prospective applicants to the Capacity Building for HBCU Archives program may: ? share affinities among the scope and subject matter of their collections; and/or ? provide a service or services to a member-based collective, consortium, or alliance of similar organizations; and/or ? serve similar types of user communities such as HBCUs. Competitive proposals will focus on one or more of the following areas: Education and Training ? To provide archival training for working professionals and other stakeholders currently working in HBCU libraries and archives that have insufficient archival training but whose essential job duties require archival activities on a regular basis. Such training should equip working professionals with practical archival tools, skills, and best practices to integrate into their daily work and archival processes at their home institution. ? To provide education and training for HBCU archivists and other stakeholders on current electronic records systems and related tools and best practices for preserving, arranging, processing, and describing these and other born-digital and digitized records collections. ? To create a “traveling archivist” or similar field-service program that will send professional archivists and librarians to provide high quality assistance on-site. Library or archival staff at partnering HBCU repositories will receive practical and affordable 3 recommendations they can undertake to improve collection preservation and access. For example, activities can include a site visit to the participating repository and a survey of their collections followed by specific recommendations made by the traveling or visiting archivist. ? To provide archival education and training programs, in collaboration with community-based archives or other local cultural memory entities, to cultivate a community of practice that can lead to cost-savings and long-term sustainability for HBCU archives. Capacity Building ? To hire consultants to assist archives and libraries at HBCUs to develop basic planning and process documents to enhance eligibility for higher levels of funding. Examples include but are not limited to the development of strategic plans, collection management plans, preservation plans, emergency plans, digital infrastructure plans; sustainability plans, and/or climate action plans. ? To provide direct assistance to HBCUs for the development of strategic plans and assessment documents to increase the capacity to sustain collections long term. Examples include but are not limited to preservation assessment, self-assessment, and/ or conservation assessment. ? To develop or expand existing models for collaboration with community-based archives or consortia that support enhanced discovery, online access to, and expanded research use of HBCU archival collections. ? To assist HBCU archives and their community-based partners in developing programs that leverage their collective professional knowledge, skills, and resources. Preservation and Digitization Preparation Grants ? To purchase or provide essential preservation needs, such as shelving, archival furniture, and related archival equipment or systems for collections management. ? To purchase or provide essential archival rehousing supplies for collections at HBCUs. This includes but is not limited to protective enclosures and archival boxes and shelving. ? To purchase or provide digitization equipment and accompanying training. ** If you have additional ideas for a possible application – whether involving one of the above suggested areas of focus, or another idea that builds the capacity of HBCU archives to care for and provide discovery and access to their collections – we strongly encourage you to get in touch to discuss your plans before drafting or making your application. All applicants are strongly encouraged to take advantage of the opportunity to submit draft materials for additional comment and feedback. (Drafts are due no later than August 15, 2024.) 4 Award Information The Capacity Building for HBCU Archives grant is for one year. Awards may range from $150,000 to $250,000 with the possibility of renewal up to two years. The NHPRC expects to make up to six grants in this category for up to $1,000,000. Applications are due on November 7, 2024. Building Capacity at HBCU Archives Grants begin no earlier than July 1, 2025. Eligibility Eligible applicants: ? US nonprofit organizations including HBCUs, educational institutions serving HBCUs, and/or similar community-based organizations serving HBCUs. ? Colleges, universities, and other academic institutions actively serving HBCUs. ? State or local government agencies. Applications from and collaborations involving Historically Black Colleges and Universities (HBCUs) are strongly encouraged. For a comprehensive list of the Commission’s limitations on funding, please see “What we do and do not fund.” Applications that consist entirely of ineligible activities will not be considered. In order to ensure eligibility, applicants should first review the rules and regulations governing NHPRC grants under the Administering an NHPRC Grant section. Cost Sharing Cost sharing is not a requirement for this program. However, the applicant's financial contribution may be included on the NHPRC Budget form. Cost share may include both direct and indirect expenses, in-kind contributions, non-Federal third-party contributions, and any income earned directly by the project. Indirect costs must be listed under the applicant’s cost sharing contribution. NHPRC grant recipients are not permitted to use grant funds for indirect costs (as indicated in 2 CFR 2600.101). Other Requirements 5 Applicant organizations must be registered in the System for Award Management (SAM) prior to submitting an application, maintain SAM registration throughout the application and award process, and include a valid Unique Entity ID in their application. To register or request a Unique Entity ID, go to https://sam.gov. Already manage an entity that does business with the federal government? You may want to consult this article on the transition from DUNS to the Unique Entity ID. Ensure your SAM.gov and Grants.gov registrations and passwords are current. It may take up to one month to register or reactivate your registration with SAM.gov and Grants.gov. NHPRC will not grant deadline extensions for lack of registration.

Amended June 7, 2024. Section 2.7 now specifies that names must be omitted from the references and citations. This supersedes the default instructions in the "Guidelines for Anonymous Proposals". New text is in bold. The due dates remain unchanged: Mandatory NOIs are due July 15, 2024, and proposals are due August 22, 2024. | PLEASE NOTE: this program has MANDATORY Notices of Intent, which are due via NSPIRES by August 22, 2024. See the full posting on NSPIRES for details. | Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package.   The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) – 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024.   This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.8 Lunar Data Analysis Program (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.pdf)” from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview.    Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list.   Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar). 

The NSF Trailblazer Engineering Impact Award (TRAILBLAZER) program supports individual investigators who propose novel research projects with the potential to innovatively and creatively address national needs and/or grand challenges, advance US leadership, and catalyze the convergence of engineering and science domains. TRAILBLAZER will support engineers and scientists who leverage their distinctive track record of innovation and creativity to pursue new research directions that are distinct from their previous or current research areas. All funded TRAILBLAZER projects will form an NSF TRAILBLAZER cohort, and principal investigators will be expected to participate in an annual meeting. TRAILBLAZER investigators may also be invited to additional activities. INFORMATIONAL WEBINAR:The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informational webinar on October 15, 2024 to discuss the TRAILBLAZER program and answer questions about the FY 2025 TRAILBLAZER solicitation. Details on how to join this webinar will be posted on theDirectorate for Engineering and EFMA Websites.

Pursuant to the Foreign Assistance Act of 1961 as amended, the United States Government as represented by the U.S Agency for International Development (USAID), Bureau for Inclusive Growth, Partnerships and Innovation (IPI), Private Sector Engagement Hub, invites concepts for the Private Sector Collaboration Pathway (PSCP) Annual Program Statement (APS). The PSCP APS provides a modernized process for USAID to provide funding in support of activities and collaborations co-created with the private sector. | While priority will be given to collaborations that are characterized by or somehow support the advancement of market-based approaches and enterprise-driven development, this PSCP APS can be used to consider, develop, and support any type of collaboration with the private sector that advances the broad objectives of USAID’s Private Sector Engagement Policy or otherwise enables the private sector to advance economic and social development in a manner deemed valuable by USAID Missions, Bureaus, and Independent Offices (M/B/IOs). Consistent with USAID’s Private Sector Engagement Policy, the focus of this APS is proactive engagement of and collaboration with the private sector in the identification and definition of key business and development problems and opportunities; the development and co-creation of market-based and market-oriented approaches to solve those problems and seize those opportunities; and the facilitation and implementation of such approaches. | NOTE: The PSCP APS is not a Request for Applications (RFA) or a Request for Proposals (RFP). Instead, the PSCP APS outlines a collaboration and co-creation process which may result in an opportunity to submit a concept to a USAID M/B/IO. Based on those concept submissions, which must demonstrate extensive engagement of and co-creation with the private sector, USAID will determine whether to continue with the co-creation process set forth under this PSCP APS. In addition, the PSCP APS is not supported by specific funds. Any funding proposed under this APS would have to be requested from the specific USAID Mission, Bureau, or Independent Office (Mission/B/IO) with which the prospective partners seek to collaborate and to which the concept will be submitted. USAID reserves the right to fund any or none of the concepts submitted under this APS. | It is the responsibility of the Applicant to ensure that the entire APS, its revisions and supporting documents have been downloaded from www.grants.gov and USAID bears no responsibility for data errors resulting from any transmission or conversion process. If you have difficulty registering on www.grants.gov or accessing the APS, please contact the grants.gov Helpdesk at 1-800-518-4726 or via email at [email protected] for technical assistance. | Thank you for your interest in USAID programs. | | |

Request for Information (RFI) on Enabling and Transformative Technologies for Superhot Geothermal Power. This is a Request for Information (RFI) only. This RFI is not accepting applications for financial assistance. The purpose of this RFI is solely to solicit input for ARPA-E consideration to inform the possible formulation of future programs. The purpose of this RFI is to seek input from researchers and technologists of various backgrounds, representing a broad range of fields and disciplines, with the goal of evaluating novel approaches to develop superhot (defined as greater than or equal to 375°C and associated pressures of roughly 22 megapascals (MPa)) enhanced geothermal power for generating electricity and other uses. These approaches should accelerate the construction of high-temperature geothermal wells that may include water in a supercritical state, or “superhot”. To view the RFI in its entirety, please visit https://arpa-e-foa.energy.gov.

The purpose of this NIH HEAL Initiative PAINCare Clinician Training Program: PCTP): Mentored Clinical Scientist Development Awards (K08) (Clinical Trials Not Allowed)is to support a cohort of new and well-trained, independent investigators. The program will provide independent NIH research support during the early-career phase to help awardeesestablish independent research programs in areas support by the NIH HEAL InitiativesClinicalResearch in Pain Management program.

Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information.   For the addresses for obtaining and submitting an application, please refer to our Revised Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on December 7, 2022.   Purpose of Program: In awarding the research grants, the Institute of Education Sciences (IES) intends to provide national leadership in expanding knowledge and understanding of (1) developmental and school readiness outcomes for infants and toddlers with or at risk for a disability, (2) education outcomes for all learners from early childhood education through postsecondary and adult education, and (3) employment and wage outcomes when relevant (such as for those engaged in career and technical, postsecondary, or adult education). The IES research grant programs are designed to provide interested individuals and the general public with reliable and valid information about education practices that support learning and improve academic achievement and access to education opportunities for all learners. These interested individuals include parents, educators, learners, researchers, and policymakers. In carrying out its grant programs, IES provides support for programs of research in areas of demonstrated national need. In awarding research training grant programs, IES aims to prepare individuals to conduct rigorous and relevant education and special education research that advances knowledge within the field and addresses issues important to education policymakers and practitioners. Competitions in This Notice: IES is announcing four research competitions through two of its centers: The IES National Center for Education Research (NCER) is announcing two competitions in the following areas: education research, and statistical and research methodology in education. The IES National Center for Special Education Research (NCSER) is announcing two competitions—one competition in each of the following areas: special education research, and special education research training. NCER Competitions Education Research Grants Program (ALN 84.305A).  Under this competition, NCER will consider only applications that address one of the following topics: ·      Career and Technical Education. ·      Civics Education and Social Studies. ·      Cognition and Student Learning. ·      Early Learning Programs and Policies. ·      English Learner Policies, Programs, and Practices. ·      Improving Education Systems: Policies, Finance, Organization, Management, and Leadership. ·      Literacy. ·      Postsecondary and Adult Education. ·      Science, Technology, Engineering, and Mathematics (STEM) Education. ·      Social, Emotional, and Behavioral Context for Teaching and Learning. ·      Teaching, Teachers, and the Education Workforce. Statistical and Research Methodology in the Education Sciences (ALN 84.305D). Under this competition, NCER will consider applications that address one of the following topics: ·      Core Grants (which supports the development of new and improved statistical and research methods and their dissemination to education researchers). ·      Toolkits, Guidelines, Compendia, Review Papers, and Curated Data Resources. NCSER Competitions Special Education Research Grants Program (ALN 84.324A). Under this competition, NCSER will consider only applications that address the following topic: ·      Education Systems. Research Training Programs in Special Education (ALN 84.324B). Under this competition, NCSER will consider only applications that address the following topic: ·      Early Career Development and Mentoring. Multiple Submissions: You may submit applications to more than one of the FY 2025 research grant programs offered through the Department, including those offered through IES as well as those offered through other offices and programs within Department. You may submit multiple applications to each IES grant program announced here as long as they address different key issues, programs, or policies.  However, you may submit a given application only once for the IES FY 2025 grant competitions, meaning you may not submit the same application or similar applications to multiple grant programs within IES, to multiple topics within a grant competition, or multiple times within the same topic. If you submit multiple similar applications, IES will determine whether and which applications will be accepted for review and/or will be eligible for funding.  In addition, if you submit the same or similar application to IES and to another funding entity within or external to the Department of Education and receive funding for the non-IES application prior to IES scientific peer review of applications, you must withdraw the same or similar application submitted to IES, or IES may otherwise determine you are ineligible to receive an award. If reviews are happening concurrently, IES staff will consult with the other potential funder to determine the degree of overlap and which entity will provide funding if both applications are being considered for funding. Exemption from Proposed Rulemaking: Under section 191 of the Education Sciences Reform Act, 20 U.S.C. 9581, IES is not subject to section 437(d) of the General Education Provisions Act, 20 U.S.C. 1232(d), and is therefore not required to offer interested parties the opportunity to comment on matters relating to grants. Program Authority: 20 U.S.C. 9501 et seq. Note: Projects will be awarded and must be operated in a manner consistent with the nondiscrimination requirements contained in Federal civil rights laws. Applicable Regulations: (a) The Education Department General Administrative Regulations in 34 CFR parts 77, 81, 82, 84, 86, 97, 98, and 99. In addition, the regulations in 34 CFR part 75 are applicable, except for the provisions in 34 CFR 75.100, 75.101(b), 75.102, 75.103, 75.105, 75.109(a), 75.200, 75.201, 75.209, 75.210, 75.211, 75.217(a)-(c), 75.219, 75.220, 75.221, 75.222, 75.230, and 75.250(a). (b) The Office of Management and Budget Guidelines to Agencies on Governmentwide Debarment and Suspension (Nonprocurement) in 2 CFR part 180, as adopted and amended as regulations of the Department in 2 CFR part 3485. (c) The Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards in 2 CFR part 200, as adopted and amended as regulations of the Department in 2 CFR part 3474. Note: The regulations in 34 CFR part 86 apply to institutions of higher education only.  Note: The open licensing requirement in 2 CFR 3474.20 does not apply to these competitions.       Assistance Listing Number (ALN) 84.305D.   |

The goal of this effort is to support the development and validation of next generation platforms and analytic approaches to precisely quantify behaviors in humans and link them with simultaneously recorded brain activity. Tools used for analyzing behavior should be multi-modal and should be able to be linked to brain activity and thus have the accuracy, specificity, temporal resolution, and flexibility commensurate with tools used to measure and modulate the brain circuits that give rise to those behaviors. This phased award will support novel tool development (i.e., hardware/software) in the R61 phase and synchronization of novel tools for measuring behavior and human brain activity in the R33 phase.

The Geophysics Program supports basic research in the physics of the solid earth to explore its composition, structure, and processes from the Earth's surface to its deepest interior. The program’s disciplinary focus spans geodesy, geodynamics, geomagnetism, heat flow, mineral physics, potential fields, seismology, rock mechanics and deformation. Within these fields, the program encourages a wide range of laboratory, field, theoretical, and/or computational studies, and encourages new methods, approaches and innovative research directions. Research questions the program addresses include but are not limited to 1) understanding geohazards, such as the fundamental geophysical processes underpinning earthquakes, volcanoes and mass flows; 2) crustal and lithospheric structure and dynamics including faulting, subduction, rifting and mountain-building processes; 3) mantle composition, structure, dynamics and evolution; 4) core structure and dynamics, geodynamo, and core-mantle interactions; 5) global and planetary-scale processes, early Earth formation and evolution, isostatic adjustment, and the magnetic field.

NOTICE: PLEASE READ - April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle.   As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. Once your concept proposal has been reviewed, you will receive an invitation to apply in EDGE. More information on how to apply is provided in the full NOFO. You must submit concept proposals to [email protected]. | | Program Description EDA provides strategic investments on a competitive merit basis to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under this NOFO, EDA solicits applications from applicants in order to provide investments that support research and technical assistance projects under EDA’s R&E and NTA programs. Grants and cooperative agreements made under these programs are designed to leverage existing regional assets and support the implementation of economic development strategies that advance new ideas and creative approaches to advance economic prosperity in distressed communities. | This NOFO employs a two-step application process: (1) the Concept Proposal and (2) the Full Application. EDA will only review Full Applications submitted by applicants who first submitted a Concept Proposal. Any Full Application received from an applicant that did not submit a Concept Proposal will be deemed ineligible and not considered for funding. For the Concept Proposal, applicants may use the optional template available at https://eda.gov/programs/rnta/resources/. Full Applications must be submitted through Grants.gov using the link that EDA will provide with its response to the Concept Proposal. | *Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required for a complete application, these forms are no longer required and have therefore been removed from the package template.

The FY24 PRCRP Impact Award supports high-impact research that can accelerate promising findings toward clinical applicability. The intent of the Impact Award mechanism is to fund mature research projects that specifically focus on critical scientific or clinical cancer issues, which have the potential to make a major near-term impact on at least one of the FY24 PRCRP Topic Areas and in at least one of the FY24 PRCRP Overarching Challenges. The critical components of this award mechanism are: ·            Impact: Research supported by the Impact Award will demonstrate the potential to accelerate promising findings and have a major impact in the near term on an area of paramount importance in cancer. The proposed study should demonstrate potential to improve patient outcomes in at least one of the FY24 PRCRP Topic Areas and in at least one of the FY24 PRCRP Overarching Challenges. Proposed projects may include translational or clinical research, including clinical trials. The potential impact of the proposed research is expected to be near-term, and while it fundamentally may include the next step in research, it must be significant and go beyond an incremental advance. The applicant must articulate the potential impact the proposed work will have on cancer research and/or patient outcomes. The Impact Award is not intended for basic research. Applicants generating preliminary data, basic research, high-risk/high-gain studies should apply to the FY24 PRCRP Idea Award (HT942524PRCRPIA). ·            Preliminary Data: The Impact Award is intended to support transformative investigations that leapfrog the cancer research field forward by utilizing previous research findings. Applications must include preliminary data to support feasibility of the study. Any unpublished, preliminary data provided should originate from the laboratory of the Principal Investigator (PI) or a member of the research team. ·            Continuity of Research: The Impact Award is intended to support established projects that have moved beyond the realm of basic research and have the potential to result in a near-term impact in clinical research or the clinic. ·            Data Evaluation: The proposed research should be rigorously designed to include a statistical plan and data analysis plan. The Impact Award is intended to have near-term relevance to patients; therefore, the statistical plan and data analysis plan should represent how significant the results and/or outcomes may be on patient outcomes. ·            Clinical Trial, if applicable: The clinical study must be initiated within the first year, including FDA Investigational New Drug/Investigational Device Exemption application submission plans within 60 days of the award.

The U.S. Mission to the UAE announces this Notice of Funding Opportunity (NOFO) for organizations to submit proposals to implement the Academy of Women Entrepreneurs (AWE) in the UAE. The 14-month program will include a 4–6-month training and mentorship program to support at least 20 UAE-based, women-owned small and medium enterprises (SMEs) build the knowledge, skills, and networks to expand market reach by taking advantage of the UAE entrepreneurship ecosystem and bilateral trade opportunities. Following the training period participants will have the opportunity to showcase successes at trade shows and policy summits | AWE in UAE is a business training program (AWE) that provides UAE-based, women-owned SMEs the knowledge, networks, and access they need to build resilience and grow their businesses. AWE UAE will convene private sector networks, U.S. Government resources/alumni, and public and private resources to establish a network Emirati and long-term UAE resident entrepreneurs and business leaders that have the capacity to develop business growth plans and leverage market expansion and media opportunities. AWE UAE supports U.S.-UAE business partnerships, public-private sponsorships, and builds institutional capacity to increase women’s access to economic opportunities.   | Since 2019, AWE has advanced women’s businesses by empowering more than 25,000 women entrepreneurs in 120+ countries. Implemented in the UAE since 2020, AWE has helped 41 women-led business, which to date have raised $7 million in funding, generated $45 million in revenues, and created 500+ jobs  |

Marginalized Palestinian areas suffer from a multitude of political, security and socio-economic problems that hinder development work and put the population at serious risk. The Palestinian Authority (PA) has limited authority and capability to reach all Palestinian areas to provide meaningful support to its residents. The School Improvement Program will implement interventions to improve the educational environment and quality of education in the most disadvantaged Palestinian areas. This program will provide support to public and private schools in the most disadvantaged Palestinian areas. The primary goal of the program is to improve access to quality education and mitigate challenges to youth development in marginalized areas. The sub-goals include: 1) Improved educational facilities through renovation.2) Improved teaching and learning through teacher training as appropriate, provision of educational resources, and collaboration with local communities.3) Expanded opportunities for youth development through extracurricular activities, career counseling and training in schools after hours.Illustrative outcomes include:• Improved human and physical educational resources that contribute to narrowing the achievement gap between students in underserved and better served Palestinian areas.• Organized and sustained extracurricular activities and youth programs.• Established networks between teachers, administrators, counselors, officials and community representatives in the targeted schools aiming at improving the quality of education and youth programming.• Enhanced community involvement in school decision-making.• Strengthened educational institutions that provide services to learners.

TheBiophotonicsprogram is part of the Engineering Biology and Health cluster, which also includes: 1) theBiosensingprogram; 2) theCellular and Biochemical Engineeringprogram; 3) theDisability and Rehabilitation Engineeringprogram; and 4) theEngineering of Biomedical Systemsprogram. The goal of theBiophotonicsprogram is to explore the research frontiers in photonics principles, engineering and technology that are relevant for critical problems in fields of medicine, biology and biotechnology. Fundamental engineering research and innovation in photonics is required to lay the foundations for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key motivating application goals. Research topics in this program include: Imaging in the second near infrared window:Research that advances medical applications of biophotonics in the second near-infrared window (NIR-II: 1,000-1,700 nm) in which biological tissues are transparent up to several centimeters in depth, making this spectral window ideal for deep tissue imaging. Macromolecule markers: Innovative methods for labeling of macromolecules. Novel compositions of matter. Methods of fabrication of multicolor probes that could be used for marking and detection of specific pathological cells.Pushing the envelope of optical sensing to the limits of detection, resolution, and identification. Low coherence sensing at the nanoscale: Low coherence enhanced backscattering (LEBS). N-dimensional elastic light scattering.Angle-resolved low coherence interferometry for early cancer detection (dysplasia). Neurophotonics:Studies of photon activation of neurons at the interface of nanomaterials attached to cells. Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networks. Microphotonics and nanophotonics:Development and application of novel nanoparticle fluorescent quantum-dots. Sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells.Nanomaterials and nanodevices for biomedicine. Optogenetics: Novel research in employing light-activated channels and enzymes for manipulation of neural activity with temporal precision. Utilizing nanophotonics, nanofibers, and genetic techniques for mapping and studying in real-time physiological processes in organs such as the brain and heart. Innovative proposals outside of these specific interest areas may be considered. However, prior to submission, it is recommended that the Principal Investigator contact the program director to avoid the possibility of the proposal being returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of PI time per year(awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the “What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)” link towards the bottom of this page. Faculty Early Career Development(CAREER)program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Learn more in theCAREER program description. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal & Award Policies & Procedures Guide(PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with theProposal & Award Policies & Procedures Guide (PAPPG)will be returned without review.

CPO plays a critical role in advancing science and informing decisions for climate adaptation, resilience, and mitigation as part of NOAA and the U.S. Global Change Research Program. CPO research/science programs and activities meet urgent climate challenges, and incubate innovative advancements in Earth system and social sciences; support world-class assessment reports, including the National Climate Assessment; enhance and expand NOAA’s capabilities for integrated information systems for drought, heat and floods to deliver timely science-based information that can reduce the impacts and costs of these climate-driven challenges; educate and grow the next generation of experts in support of NOAA’s climate mission. Through these new investments, CPO expands previous efforts focused on climate risks addressing a suite of urgent climate-driven societal challenges faced by our Nation — including water availability and quality, marine and freshwater ecosystems, coastal changes and inundation, drought and extreme heat and related cascading hazards like wildfire, and air quality, and climate mitigation (more information about CPO Societal Challenges and Risks framework can be found (here).    NOAA, OAR, and CPO require applicants and awardees to support the principles of diversity and inclusion when writing their proposals and performing their work; indeed, applicants will be evaluated, in part, on how well principles of diversity and inclusion are addressed. Diversity is defined as a collection of individual attributes that together help organizations achieve objectives. Inclusion is defined as a culture that connects each employee to the organization. Promoting diversity and inclusion improves creativity, productivity, and the vitality of the climate research community in which CPO engages. |

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficient to inform the planning of a Phase II-IV clinical trial within NHLBI's mission. The NHLBI expects that applications to this NOFO will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this NOFO will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention and/or treatment of heart, lung, blood, and sleep disorders. In contrast to the study start up or preparation phase of NHLBI funding opportunities for clinical trials (as described at https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities-and-contacts/clinical-trials-optimization), the R34 mechanism is intended to provide new information that answers a scientific or operational question(s) which may be pragmatic in nature and, therefore, informs the final development of a Phase II-IV clinical trial. Regardless of the results of the R34, support of the proposed future clinical trial will require a new application.

The United States Agency for International Development (USAID) Mission in Colombia is making a special call for the submission of Concept Papers focused on leveraging private sector investment and expertise that results in enhance sustainable and inclusive development in Colombia’s conflict-affected areas. Subject to the availability of funds, USAID/Colombia may allocate up to $10,000,000 to fund a portfolio of GDA alliances with the private sector, with funding for individual applications estimated in the range of $1,500,000 to $5,000,000 to be implemented over a period of 3-5 years through 2 to 3 awards, depending on the approach of each individual application.

The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical genomics community. Work supported under this FOA should be enabling for genomics and be generalizable or broadly applicable across diseases and biological systems. All applications should address how the methods would scale to address increasingly larger data sets.

The primary objective of the Cultural Anthropology Program is to support fundamental, systematic anthropological research and training to increase understanding of the causes, consequences and complexities of human social and cultural variability. The Cultural Anthropology Program welcomes proposals from researchers in all sub-fields of cultural anthropology and research at any temporal or spatial scale. Methodologies and approaches employed may include ethnographic field research, surveys, remote sensing, the collection of bio-markers, experimental research inside or outside of laboratory settings, archival research, the analysis of materials collections and extant data bases, mathematical and computational modeling and other research tools as appropriate for the proposed research. The overarching research goals should be to produce empirically grounded findings that will be generalizable beyond particular case studies and contribute to building a more robust anthropological science of human society and culture. The National Science Foundation's mandate is to support basic scientific research. Basic research in cultural anthropology means theory-generating and theory-testing research that creates new knowledge about human culture and society. Therefore, the Cultural Anthropology Program cannot support research that takes as its primary objective improved clinical practice, applied policy or other immediate application. Research that seeks to advance scientific cultural anthropological theories in a way that advances use-inspired objectives may be supported, but the theory-advancing objectives must be clearly at the center of the proposal. A proposal to use anthropological methods and approaches only to find solutions to social, medical or other problems without specifically proposing to make a theory-testing or theory-expanding contribution to anthropological science will be returned without review.

Orthopaedic injuries have a profound impact on military readiness and return to work/activity/duty. In the military, extremity battle wounds comprise approximately 50% of injuries reported in the Department of Defense Trauma Registry. Additionally, orthopaedic injuries and conditions that occur outside of combat (e.g., during training, leisure activities, resultant from old injuries) present one of the greatest threats to the readiness of our Service Members and military. Early stabilization, treatment, and rehabilitation of orthopaedic injuries in both civilian and military populations have led to better outcomes, particularly in the prevention of secondary complications and in minimizing morbidity. Availability of orthopaedic care and treatment as early as possible, or as close to the point of injury as possible, also minimizes limb loss and affects military readiness.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the selected Focus Area.The PRORP CTA supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of military combat or service-related orthopaedic injuries that significantly impact unit readiness and return-to-duty/work rates. Applicants are encouraged to address how the proposed research will support patient care closer to the point of injury and/or allow patients to more quickly return to duty/work. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first-in-human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations.The FY24 PRORP CTA differs from the FY24 PRORP Clinical Translational Research Award (CTRA) in that the CTRA allows for clinical research projects that may or may not include a clinical trial, whereas the CTA is restricted to clinical trials only.Funding from this award mechanism must support a clinical trial and may not be used for animal or preclinical studies. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.All applications submitted to this program announcement, regardless of the selected Focus Area, are eligible for Research Level 1.Collaborative Care Option (Research Level 2): Applications submitted to the FY24 PRORP CTA, with Focus Area Translation of Early Findings – Soft Tissue Trauma, are eligible for a Collaborative Care Option (Research Level 2); refer to Section II.D.5, Funding Restrictions. The Collaborative Care Option provides additional support to encourage collaborative interdisciplinary research among physical therapists, occupational therapists, prosthetists, surgeons, and other orthopaedic care providers. The proposed research should include both surgical and rehabilitation strategies that create a cohesive project. Surgical strategies are reconstruction and repair and/or application of biologics, pharmaceuticals, and devices for the purpose of restoration of native architecture, composition, and function of traumatically injured tissues. Rehabilitative strategies are those that restore function following injury or illness, with the goal of optimal health and independence. Projects should integrate principles and approaches from surgical and rehabilitative strategies, beyond what each approach would provide by itself, with the goal of optimizing form, function, and independence for those who have sustained traumatic orthopaedic injuries. The rehabilitation strategy and the standard of care must be specified. Projects that follow patients across the continuum of care are highly encouraged. To encourage meaningful and productive multidisciplinary collaborations, projects submitted for this option must include at least one investigator with orthopaedic rehabilitation expertise and at least one clinician who specializes in orthopaedic or trauma care. A Letter of Collaboration is required from each specialist (i.e., rehabilitation expert and surgeon) who is serving as Key Personnel, excluding the Principal Investigator (PI), on the application. A clinician is defined as an individual who is credentialed (possesses the necessary degrees, licenses, and other certifications) and practicing as a care provider in a relevant capacity.If the proposed research includes a clinical trial of an investigational product to be conducted at international sites, an application to the relevant national Regulatory Agency of each host country must be submitted within 6 months of the award date.The government reserves the right to withdraw funding if an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application and/or international regulatory application is necessary but has not been submitted within 6 months of the award date.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdf.Key aspects of the PRORP CTA mechanism:• Clinical Trial Start Date: The proposed clinical trial is expected to begin no later than 6 months after the award date, or 12 months after the award date for studies regulated by the Regulatory Agency.• Preliminary Data Are Required: Inclusion of preliminary data relevant to the proposed clinical trial is required.• Study Population: The application should demonstrate the availability of and access to a suitable patient population that will support a meaningful outcome for the study. The application should include a discussion of how accrual goals will be achieved, as well as the strategy for inclusion of women and minorities in the clinical trial appropriate to the objectives of the study. Studies utilizing human biospecimens or datasets that cannot be linked to a specific individual, gender, ethnicity, or race (typically classified as exempt from Institutional Review Board [IRB] review) are exempt from this requirement.• Intervention Availability: The application should demonstrate the documented availability of and access to the drug/compound, device, and/or other materials needed, as appropriate, for the proposed duration of the study.• Personnel and Environment: The application should demonstrate the study team’s expertise and experience in all aspects of conducting clinical trials, including appropriate statistical analysis, knowledge of U.S. Food and Drug Administration (FDA) processes (if applicable), and data management. The application should include a study coordinator(s) who will guide the clinical protocol through the local IRB of record and other federal agency regulatory approval processes, coordinate activities from all sites participating in the trial, and coordinate participant accrual. The application should show strong institutional support and, if applicable, a commitment to serve as the FDA regulatory sponsor, ensuring all sponsor responsibilities described in 21 CFR 312, Subpart D, are fulfilled.• Statistical Analysis and Data Management Plans: The application should include a clearly articulated statistical analysis plan, a power analysis reflecting sample size projections that will answer the objectives of the study, and a data management plan that includes use of an appropriate database to safeguard and maintain the integrity of the data. If required by a Regulatory Agency, the trial must use a 21 CFR 11-compliant database and appropriate data standards.Women’s Health Research: The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.Use of DOD or VA Resources: If the proposed research involves access to DOD or VA resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Refer to Section II.D.2.b.ii, Full Application Submission Components, for detailed information. Refer to the General Application Instructions, Appendix 1, for additional information.For the purposes of this funding opportunity, Regulatory Agency refers to the FDA or any relevant international Regulatory Agency unless otherwise noted.If the proposed clinical trial involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an IND application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the IRB of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency within 6 months of the CTA award start date. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an IDE, or equivalent, application that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the IDE application, or equivalent, must be submitted to the relevant Regulatory Agency within 6 months of the CTA award start date. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP CTA should not exceed $2.5M (Research Level 1) or $3.25M (Research Level 2). Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $13.25M to fund approximately four Research Level 1 and one Research Level 2 CTA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

Reissue: RFA-NS-21-023 - The purpose of this Funding Opportunity Announcement (FOA) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

The PEPFAR Coordination Office of the U.S. Embassy in Yaoundé, Cameroon announces an open competition for youth-led organizations to submit applications under the FY 2024-2026 PEPFAR Youth Catalytic Innovation Fund program for youth, to strengthen the operational and advocacy capacities of youth led organizations enrolled in the Catalytic Youth Initiative program by 2026, to directly provide resources to youth-led organizations in Cameroon by 2026, to enhance their ability to do HIV advocacy, effectively address HIV prevention, treatment and support within their communities and to improve HIV prevention, care and treatment services for youth in Cameroon by 2026 through the Catalytic Youth Initiative program. | Note: Grant awards are contingent on the receipt of funding. If the program is not approved, no grants will be awarded under this call.

The purpose of the Specialty Crop Research Initiative (SCRI) program is to address the critical needs of the specialty crop industry by awarding grants to support research and extension that address key challenges of national, regional, and multi-state importance in sustaining all components of food and agriculture, including conventional and organic food production systems. Projects must address at least one of five focus areas: | Research in plant breeding, genetics, genomics, and other methods to improve crop characteristicsEfforts to identify and address threats from pests and diseases, including threats to specialty crop pollinatorsEfforts to improve production efficiency, handling and processing, productivity, and profitability over the long term (including specialty crop policy and marketing)New innovations and technology, including improved mechanization and technologies that delay or inhibit ripeningMethods to prevent, detect, monitor, control, and respond to potential food safety hazards in the production efficiency, handling and processing of specialty crops |

**UPDATE 5 APRIL 2024: The proposal submission date has been updated to 24 April 2024. The FOA has been amended to reflect this submission date and include a Question and Answer document based on questions received from interested applicants. Other than the updated proposal submission date in the FOA, the actual FOA Amendment has not been changed. However, the answers provided in the Q&A document are considered part of the FOA Amendment.** | **CYCLE 2 UPDATE 20 MARCH 2024 - THE OPPORTUNITY WEBINAR FOR CYCLE 2 WILL BE HELD ONLINE VIA MS TEAMS AT 1500 EDT ON 22 MARCH 2024 AT THE FOLLOWING LINK: | https://dod.teams.microsoft.us/l/meetup-join/19%3adod%3ameeting_5fa41fe6fa874484b473d8a6ba7921c6%40thread.v2/0?context=%7b%22Tid%22%3a%22fae6d70f-954b-4811-92b6-0530d6f84c43%22%2c%22Oid%22%3a%22e9f6fc39-8f22-44e5-8bd0-64f0cde32305%22%2c%22IsBroadcastMeeting%22%3atrue%7d | **UPDATE 14 MARCH 2024 - CYCLE 2 HAS BEEN POSTED TO THE ANNOUNCEMENT. PLEASE REVIEW THE UPDATED ANNOUNCEMENT IN FULL FOR SUBMISSION TIME, UPDATED TOPIC, AND FUNDING AMOUNT AND SCHEDULE CHANGES FROM CYCLE 1** | TACTICAL BEHAVIORS FOR AUTONOMOUS MANEUVER COLLABORATIVE RESEARCH PROGRAM (TBAM-CRP) | Future Army forces will be called upon to operate and maneuver in multi-domain operations (MDO), against a modern and capable peer adversary. The battlefield of the future may impose additional constraints on maneuver forces such as disruption in communication as well as positioning services. To field a highly capable fighting force in this future battlefield, novel tactics and doctrines leveraging nascent technologies in robotics and autonomous systems (RAS) will need to be developed. Teams of RAS will serve an increasingly critical role in the future force to deliver situational awareness, defend key locations or positions, or take point in dynamic and hazardous situations. Resilience to disruptions, failures, or unexpected scenarios, is a key quality for teams of RAS to operate alongside other future Army forces. The US Army Combat Capabilities Development Command (DEVCOM) Army Research Laboratory (ARL) is focused on developing fundamental understanding and informing the art-of-the-possible for warfighter concepts through research to greatly improve the scope of mission capabilities of teams of RAS, develop robust and resilient approaches to plan under extreme conditions of uncertainty, to learn coordinated strategies for groups of agents to achieve a common objective, all within a complex maneuver environment including adversaries. The Tactical Behaviors for Autonomous Maneuver Collaborative Research Program (TBAM-CRP) is focused on developing and experimentally evaluating coordinated and individual behaviors for small groups of autonomous agents to learn doctrinal as well as novel tactics for maneuvering in military relevant environments. The TBAM-CRP will leverage developments in other internal and extramural programs as well as identify new research directions to find novel solutions to these maneuver problems in analogical simulations representing complex realistic terrain. | The Tactical Behaviors for Autonomous Maneuver Collaborative Research Program (TBAM-CRP) will consist of a series of sprint efforts executed with annual program reviews. Each topic will be focused on addressing a different set of scientific areas which will support the research aims of an associated ARL researcher from a related internal essential research program (ERP) or mission-funded program. | The TBAM-CRP has been developed in coordination with other related ARL-funded collaborative efforts (see descriptions of ARL collaborative alliances at https://www.arl.army.mil/business/collaborativealliances/) and shares a common vision of highly collaborative academia-industry-government partnerships; however, it will be executed with a program model adapted from the Scalable, Adaptive, and Resilient Autonomy (SARA), which established a new paradigm for collaborative research. Some key properties of this new approach are described below: | • TBAM-CRP sprint topics will be offered on a two-year cycle. Proposals will be solicited for a possible two-year period structured as a first-year pilot followed by a second-year option where the option may be awarded based upon progress assessed at an annual review. The FOA will be amended annually to identify a specific problem statement and scope for that specific cycle. The topics for each cycle will be chosen to address the long-term program goal. • Five new topics (Cycles 1-5) are expected in FY22, 24, 26, 28, 30. Each topic will be carefully chosen based on the previous accomplishments in the prior cycle(s), the development of new technologies and capabilities in the broader research and development communities, and the Army’s evolving needs for future capabilities. • For each topic, funding will be provided to those Recipients selected under a cooperative agreement (CA). • Enhanced Research Program funding from ARL or Other Government Agencies (OGAs) may become available during a cycle which provides a mechanism for growth and enhancement within the TBAM-CRP. A proposal should not include any discussion of the Enhanced Research Program. Recipients receiving a CA will be notified and provided details if the opportunity for Enhanced Research Program funding becomes available during their award period of performance. • There is no limitation on the place of performance, although on-site collaboration at ARL facilities and with ARL researchers as well as with other Recipients are encouraged. Research outcomes in this program must, at the very least, be demonstrated in sophisticated simulations of relevant environments. Together with ARL collaborators, these results may be adapted for higher TRL experimentation on surrogate platforms at ARL test facilities such as the Robotics Research Collaboration Campus (R2C2) at Graces Quarters, Aberdeen Proving Ground, Maryland. • Recipients will be furnished with access to the ARL Autonomy Stack software suite as well as all relevant simulation tools and multi-agent learning support. • Recipients will be provided with information about the current state of the Autonomous Systems Enterprise (ASE) with an overview of developments in the associated collaborative research alliances including Distributed and Collaborative Intelligent Systems and Technology (DCIST), Scalable, Adaptive, and Resilient Autonomy (SARA), as well as internal ARL essential research programs including the AI for Maneuver and Mobility (AIMM), Emerging Overmatch Technologies (EOT), and Versatile Tactical Power and Propulsion (VICTOR). Capabilities demonstrated in simulation should reflect significant appropriate developments. This midpoint review is expected to take place as a mini symposium where Recipients can share results with one another along with the ARL community to foster further collaboration. • At the end of the second year, a capstone demonstration will be executed by those Recipients receiving an option to their award in a set of simulated relevant environments, either those environment scenarios provided by the Government and other program performers, or optionally of a specific environment developed by the Recipient to exhibit their developed capability. Any system level capability demonstration that can be made with the internal ARL collaborator or description of capability development and program contribution can also be made at this time. These system demonstrations are expected to coincide to foster further integration and adoption with related internal research programs as well as partner organizations from within the DEVCOM, other Army and DoD service branches and agencies, in addition to other government agencies. | Proposals that follow the requirements of the FOA will be evaluated in accordance with merit-based, competitive procedures. These procedures will include evaluation factors and an adjectival and color rating system. A review team, consisting of a qualified group of Government scientists and managers will evaluate the compliant proposals and provide the results of that evaluation to the decision-maker for the Government. Relevant internal research program materials approved for public release and contact information will be provided to potential proposers during introductory presentations to help facilitate identification of collaboration between proposers and individual ARL researchers or internal research programs. Additional connections to ARL programs can be identified during the proposal review process. | Eligible applicants under this FOA include institutions of higher education, nonprofit organizations, and for-profit organizations (i.e., large and small businesses) for scientific research in the knowledge domains outlined throughout this Funding Opportunity. Federally Funded Research and Development Centers (FFRDC) may propose as well, with effort as allowed by their sponsoring agency and in accordance with their sponsoring agency policy.

Reissue of PAR-19-146 This Funding Opportunity Announcement (FOA) supports the discovery of novel compounds for the prevention and treatment of nervous system disorders. Through this FOA NIMH and NIA wish to stimulate research in: 1) Identification, design, synthesis, and preclinical testing of compounds of candidate therapeutics; 2) Initial hit-to-lead chemistry to improve activity of compounds against the target of interest; 3) Later stage lead optimization to improve efficacy and pharmacokinetics; and 4) Initial drug metabolism and pharmacokinetic (DMPK). Emphasis will be placed on projects that provide novel approaches for identifying potential therapeutic agents.

The FY24 TBIPHRP ETRA intends to accelerate research in emerging topics in traumatic brain injury and/or psychological health. Findings from the FY24 ETRA-funded research should ultimately support the generation of new or updated clinical applications, health care products, and clinical practice guidelines for Service Members, their Families, Veterans, and the American public.Research Scope: Applications to the FY24 TBIPHRP ETRA may include preclinical applied research (including animal research) and clinical research (including clinical trials). Applications must not include basic research21. The FY24 TBIPHRP ETRA may also support ancillary studies that are associated with an ongoing or completed clinical trial and projects that optimize the design of future clinical trials. This award may not be used to support studies requiring an exception from informed consent (EFIC). Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), diagnostics, devices, therapies, clinical guidance, behavioral interventions, emerging approaches and technologies, and/or new indications for products currently U.S. Food and Drug Administration (FDA)-approved or -cleared.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document.pdf.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under §46.104(d)(4) of the Common Rule.Applications that include a clinical trial as part of the proposed research will have additional submission requirements and review criteria. For more information, see Section II.D.2, Content and Form of the Application Submission and Section II.E.1, Criteria. Funded clinical trials are required to post a copy of the informed consent form used to enroll subjects on a publicly available federal website in accordance with federal requirements described in the 32 CFR 219.Multi-Institutional Clinical Research/Trials: As of January 20, 2020, U.S. institutions engaged in non-exempt cooperative research must rely on a single Institutional Review Board (IRB) to review and approve the portion of the research conducted at domestic sites (45 CFR 46.114(b)). If the proposed, non-exempt research involves more than one U.S.-based institution, a written plan for single IRB review arrangements must be provided at the time of application submission or award negotiation. The lead institution responsible for developing the master protocol and master consent form should be identified and should be the single point of contact for regulatory submissions and requirements.Communication and data transfer between or among the collaborating institutions, as well as how specimens and/or imaging products obtained during the study will be handled, should be included in the appropriate sections of the application. A separate intellectual and material property plan agreed on by all participating institutions is also required for multi-institutional clinical research/trials.Research Levels: The FY24 TBIPHRP ETRA offers funding for two Research Levels (refer to Section II.D.5, Funding Restrictions). Only one Research Level category may be chosen per application. It is the responsibility of the applicant to select the level that aligns with the scope of the proposed research. The Research Level should be selected based on the research scope and not on the amount of the budget. The following are generalized descriptions of the scope of the research appropriate for each Research level:• Research Level 1: Research Level 1 is intended to support smaller scope, less complex preclinical clinical research, or pilot/exploratory clinical trials. The maximum period of performance is 3 years. The application’s direct costs budgeted for the entire period of performance should not exceed $700,000.• Research Level 2: Research Level 2 is intended to support larger scope, more complex preclinical, clinical research, or clinical trials. The maximum period of performance is 4 years. The application’s direct costs budgeted for the entire period of performance should not exceed $1.5M.o Early-Career Investigator Partnering Option: The FY24 TBIPHRP ETRA (Research Level 2 only) includes an Early-Career Investigator Partnering Option that is structured to accommodate two Principal Investigators (PIs), one of whom is an Early-Career Investigator. The combined direct costs budgeted for the entire period of performance in the applications of the Initiating PI and Partnering PI should not exceed $1.5M. o The PIs may have experience in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application. One PI will be identified as the Initiating PI and will be responsible for most of the administrative tasks associated with application submission. The other investigator will be the Partnering PI. At least one of the Initiating or Partnering PIs must be an Early-Career Investigator.o The intent is not to create mentor-mentee arrangement. Both PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. The application is expected to describe how the PIs’ unique experience/expertise combined as a partnership will better address the research question, how the unique experience/expertise that each individual brings to the application is critical for the research strategy and completion of the SOW, and why the work should be done together rather than through separate efforts.o If recommended for funding, each PI will be named to an individual award within the recipient organization(s). For individual FY24 TBIPHRP ETRA submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.Rigor of Preclinical Research Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 9, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.If animal models are proposed, consider the following:• Pairing clinical populations to animal models in order to validate the clinical relevance and development of prevention, assessment, and treatment solutions is encouraged.• Proposed animal models should be well justified, supported within the literature, and clearly align with clinical relevance to the human condition.Relevance to Military Health: Relevance to the health care needs of Service Members, their Families, and Veterans is a key feature of this award. Investigators are encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health:• Explanation of how the project addresses an aspect of psychological health conditions and/or TBI that has direct relevance to the health and/or readiness of Service Members, their Families, and Veterans.• Description of how the knowledge, information, products, or technologies gained from the proposed research could be implemented in a dual-use capacity to benefit the civilian population and also address a military need.• Use of military or Veteran populations, samples, or datasets in the proposed research, if appropriate.Collaborations between researchers or consultants at military or Veterans organizations and non-military organizations are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique data and research resources that the partners bring to the research effort, ultimately advancing TBI and psychological health research of significance to Service Members, their Families, and Veterans. A list of websites that may be useful in identifying additional information about ongoing DOD and VA areas of research interest or potential opportunities for collaboration can be found in Appendix 2.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $16.0M to fund approximately four ETRA Research Level 1 applications and five ETRA Research Level 2 applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The National Science Foundation (NSF) Convergence Accelerator program addresses national-scale societal challenges through use-inspiredconvergence research. Using a convergence approach and innovation processes like human-centered design, user discovery, and team science and integration of multidisciplinary research, the Convergence Accelerator program seeks to transition basic research and discovery into practice—to solve high-impact societal challenges aligned with specific research themes (tracks). NSF Convergence Accelerator tracks are chosen in concordance with the themes identified during the program’s ideation process that have the potential for significant national impact.The NSF Convergence Accelerator implements a two-phase program. Both phases are described in this solicitation and are covered by this single solicitation and corresponding Broad Agency Announcement. The link to the corresponding Broad Agency Announcement can be found at https://sam.gov/opp/0c859c722d1148a983447287ccd81c61/view.The purpose of this parallel funding opportunity is to provide increased opportunities for proposals that are led by non‑academic entities. Proposals that are led by Institutions of Higher Education (IHEs), non-profits, independent museums, observatories, research labs, professional societies and similar organizations should respond to this solicitation. Proposals led by for‑profit or similar organizations should respond to the BAA.Phase 1 awardees receive resources to further develop their convergence research ideas and to identify important partnerships and resources to accelerate their projects. Phase 2 awardees receive significant resources leading to deliverable research prototypes and sustainability plans. This solicitation for FY 2023 invites proposals for the following Track Topics: Track K: Equitable Water Solutions The objective of the NSF's Convergence Accelerator Track K: Equitable Water Solutions is to build upon foundational knowledge and advancements in environmental sciences, geosciences, engineering, computing, social and behavioral sciences, as well as other areas to develop viable solutions for water quality, quantity, and equity issues. Track L: Real-World Chemical Sensing Applications The overarching goal of NSF's Convergence Accelerator Track L: Real-World Chemical Sensing Applications is to develop novel energy-efficient and miniaturized or portable biological and chemical sensors for tangible applications. Track M: Bio-Inspired Design Innovations The overarching goal of NSF's Convergence Accelerator Track M: Bio-Inspired Design Innovations is to bring together scientists and practitioners to develop concepts, approaches, and technologies that build and control in the same way nature does – capitalizing on millions of years of evolution – to find novel solutions to major societal and economic challenges. | It must be evident how the proposed work will be integrated to achieve success of the entire track. Each proposal should include a description of how the proposed project will contribute to an integrated environment that will deliver beneficial outputs for the track. It should also be clear how the projects will convergently align with the overarching goal of each track rather than as independent projects. Proposers are required to submit a Letter of Intent in order to submit a Phase 1 Full Proposal. The information required in the Letter of Intent is described in Section V. Letters of Intent should identify a team with the appropriate mix of disciplinary and cross-sector expertise required to build a convergence research effort. Letters of Intent must identify one or more deliverables, how those research outputs could impact society at scale, and the team that will be formed to carry this out. Phase 1 proposals must describe the deliverables, a research plan, and the process of team formation that will help lead to a proof-of-concept during Phase 1. If selected, Phase 1 awards may receive funding up to $750,000 for 12 months duration, of which nine months includes intense hands-on activities, centering around the Program’s innovation curriculum, and three months of other activities, such as participation in the NSF Convergence Accelerator Pitch Presentations. During the nine-month intensive planning phase, teams will participate in a curriculum that will assist them in strengthening team convergence and accelerating the identified idea toward Phase 2. The curriculum provides modules on innovation processes, including human-centered design, user discovery, team science, and integration of multidisciplinary partnerships. Teams will also be provided with coaches who will support them in Phase 1 and who may continue with them into Phase 2 if the teams choose to continue with the same coach. Alternatively, the teams can request to work with a different coach. Only awardees of Phase 1 awards under this solicitation may submit a Phase 2 proposal. Phase 2 proposals must outline a 36-month research and development plan that transitions research into practice through convergence activities, multi-sector partnerships, and collaboration with other partners and end-users. If selected for Phase 2, teams will be expected to apply program fundamentals and innovation processes gained in Phase 1 to enhance partnerships, develop a solution prototype, and build a sustainability model to continue societal impact beyond NSF support. Phase 2 awards may be up to $5 million for 36 months. Phase 2 proposals must clearly describe deliverables that will be produced within 36 months. The Phase 2 teams must include partnerships critical for success and end-users (e.g., industry, Institutions of Higher Education (IHEs), non-profits, government, and others), each with a specific role(s) in deliverable development and facilitating the transition of research outputs into practical uses. Successful Phase 2 proposals will be funded initially for 12 months, with subsequent years being provided on the basis of an assessment of performance (see below). Each Phase 2 team’s progress will be assessed during the year through approximately four virtual and/or in-person meetings with NSF program staff. At the end of 12 months, overall progress will be evaluated based on a report and presentation that the team presents to a panel of internal and/or external reviewers. The review panel will include NSF reviewers and staff, and competing teams only.Phase 2 teams that show significant progress during the first year in accordance with the agreed timetable of milestones and deliverables will receive funding for subsequent years. Phase 2 teams must plan on completing the effort within 36 months. No-cost extensions arenotpermitted except under clearly documented exceptional circumstances. Grantees must first contact the cognizant Program Officer prior to submitting a request. The NSF Convergence Accelerator program is committed to research that derives expertise from and provides broad benefits to everyone. The program places a very strong emphasis on broadening participation by encouraging proposals from, and partnerships with, minority-serving institutions (see U.S. Department of Education).

“It is the policy of my Administration to advance women’s health research, close health disparities, and ensure that the gains we make in research laboratories are translated into real-world clinical benefits for women. It is also the policy of my Administration to ensure that women have access to high-quality, evidence-based health care and to improve health outcomes for women across their lifespans and throughout the country.” – President Joseph R. Biden, Jr., Executive Order 14120 on Advancing Women’s Health Research and Innovation, 18 March 2024.In support of the President’s Executive Order to advance women’s health research, the PRORP is releasing this WHRA funding opportunity. The intent of the FY24 PRORP WHRA is to support research focused on orthopaedic issues faced by women serving in military settings, such as infantry and other physically demanding roles, who have sustained orthopaedic injuries. The overall goal of the WHRA is to address factors that contribute to the health and retention of women in military service. Although use of military populations, datasets, or samples are not required, the application should demonstrate how the proposed research relates to issues faced by women serving in military settings. The proposed research project should also include a well-formulated, testable hypothesis based on sound scientific rationale and logical reasoning.Although the PRORP is interested in supporting military-focused research, research supported by the PRORP is expected to also apply to all individuals who have sustained a major orthopaedic injury.The PRORP encourages applications from a spectrum of research areas, including but not limited to translational and clinical research. The PRORP also welcomes qualitative research, population science, and health care services research specifically designed to understand the impact of orthopaedic injuries on female Service Members.With the initiation of the Arthritis Research Program, the FY24 PRORP may not fund arthritis research; however, research that addresses conditions or health abnormalities related to arthritis is permitted provided the proposed research addresses the PRORP WHRA’s focus on orthopaedic injuries in women.A key feature of the PRORP WHRA is the relevance to female military and/or Veteran populations following orthopaedic injury. Inclusion of female military and/or Veteran populations is highly encouraged for applications proposing clinical research. Applicants proposing clinical studies in non-military and/or non-Veteran populations must justify the relevance of the proposed research to the military and/or Veteran communities. All applicants should clearly describe how their study design, including recruitment strategies and access to appropriate populations, as applicable, will enable them to meet this intent.Research involving human subjects, human datasets, and human anatomical substances is permitted; however, the WHRA may not be used to conduct clinical trials. Applicants seeking support for a clinical trial should consider the FY24 PRORP Clinical Trial Award (Funding Opportunity Number HT942524PRORPCTA).Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under §46.104(d)(4) of the Common Rule.A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 7, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.Encouraged Department of Defense (DOD) and/or VA Collaboration: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the VA, and other federal government agencies are encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated total costs budgeted for the entire period of performance for an FY24 PRORP WHRA should not exceed $1.5M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $3.0M to fund approximately two WHRA applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The Civic Innovation Challenge (CIVIC) is a research and action competition that accelerates the transition to practice of foundational research and emerging technologies into communities through civic-engaged research. By addressing priorities at the local scale that are relevant across the US, CIVIC is laying the foundation for a broader and more fluid exchange of research and technology capabilities and civic priorities through joint partnerships involving civic partners and the research community. CIVIC funds projects that pilot state-of-the-art solutions to community challenges over 12 months, following a six-month planning phase, and have the potential for lasting impact in the partnering community as well as the potential to be scaled and implemented in other communities. Additionally, the foundation for CIVIC projects should be rooted in maturing and transitioning state-of-the-art research in disciplines, including but not limited to computer science, engineering, geosciences, biological sciences, and social sciences. CIVIC is uniquely designed to enable transition to practice of innovations into communities, as follows: (1) CIVIC flips the community-university dynamic, by empowering communities and researchers to jointly identify civic priorities ripe for innovation and to address these priorities as equal partners; (2) CIVIC focuses on research-centered solutions that are ready for piloting in and with communities on a short timescale, where real-world outcomes can be evaluatedwithin 12 months; (3) CIVIC requires a coalition of communities and civic partners and a multi-disciplinary set of researchers to co-create and execute pilot projects; and (4) CIVIC organizes and fosters nationwide “communities of practice” around high-need problem areas that allow for meaningful knowledge sharing and cross-site collaboration during both the pre-development and piloting stages. For this solicitation, civic partnership and engagement activities, communities, and academic and civic partners must be based in the United States or its protectorates. For purposes of clarity, civic partners may include local, state, or tribal government officials; non-profit representatives; community organizers or advocates; community service providers; and/or others working to improve their communities. CIVIC is organized as a two-stage competition withtwo tracks centered around the following topic areas: Track A. Climate and Environmental Instability - Building Resilient Communities through Co-Design, Adaption, and Mitigation Track B. Bridging the gap between essential resources and services & community needs. In Stage 1,approximately 35-40 Planning Grant awards will be made – each with a budget of up to $75,000 for six months to undertake planning and team development activities. These include solidifying the team, maturing the project plans, and preparing a well-developed full proposal for submission to Stage 2.Only Stage 1 CIVIC recipients can submit to the CIVIC Stage 2 competition. In Stage 2,approximately20 Full Awards will be made. These will be selected from Stage 1 award recipients. For Stage 2, proposals will be considered with budgets up to $1,000,000 for up to 12 months. Proposals must describe how the PIs will execute and evaluate their research-centered pilot projects. Throughout both stages, NSF award recipient (2223449) MetroLab Network (metrolabnetwork.org, nsfcivicinnovation.org) will foster “communities of practice” through in-person and virtual activities, aimed at enhancing the teams’ capacity-building, networking, impact, and ability to create methods and solutions transferable to other communities. The CIVIC research and action competition is jointly supported by NSF’s Directorate for Computer and Information Science and Engineering (CISE); Directorate for Engineering (ENG);Directorate for Geosciences (GEO); Directorate for Social, Behavioral, and Economic Sciences (SBE); Directorate for Biological Sciences (BIO); and the Department of Energy (DOE), and the Department of Homeland Security (DHS).

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by October 1, 2024. See the full posting on NSPIRES for details. | Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package.   The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) – 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024.   This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.8 Lunar Data Analysis Program (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.pdf)” from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview.    Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list.   Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).   

OJP is committed to advancing work that promotes civil rights and equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety, protects the public from crime and evolving threats, and builds trust between law enforcement and the community. With this solicitation, BJA seeks to award Edward Byrne Memorial Justice Assistance Grant (JAG) Program funds to eligible states. BJA will issue a separate solicitation for applications from units of local government. For more information on the JAG Program, please refer to the JAG Fact Sheet and/or JAG Frequently Asked Questions (FAQs). Statutory Authority: The JAG Program is authorized by Title I of Public Law 90-351 (generally codified at 34 U.S.C. 10151-10726), including subpart 1 of part E (codified at 34 U.S.C. 10151-10158); see also 28 U.S.C. 530C(a).

This letter is to call your attention to a new activity that will support research collaboration between US scientists and scientists in developing countries as part of ongoing or new Plant Genome Research Program awards. The Developing Country Collaborations in Plant Genome Research (DCC-PGR) is an addendum to the NSF Program Solicitation, NSF 04-510, Plant Genome Research Program (PGRP) (http://www.nsf.gov/pubsys/ods/getpub.cfm?nsf04510). The intent of DCC-PGR awards is to support collaborative research linking US researchers with partners from developing countries to solve problems of mutual interest in agriculture, energy and the environment, while placing US and international researchers at the center of a global network of scientific excellence. The long-term goal of these collaborative research efforts is a greater and sustained engagement with developing countries in plant biotechnology research. In order to realize the full potential of biotechnology for the developing world, the technology must target crops grown locally in the developing countries and the traits that are most relevant to the local farmers and consumers. At the same time, proposals should meet the broad goals of the PGRP described in the current Program Solicitation. Of special interest are those research projects that build on prior PGRP investments and that tackle problems specific to crops grown in the developing world. A request for supplemental funding should be made under an existing PGRP award. Support can also be requested within a proposal for a new or renewal PGRP award. Proposed collaborative activities are encouraged that focus on research problems important to developing countries and that include scientist-to-scientist interactions potentially leading to long-term partnerships among participating laboratories. The exchange of ideas and people should be reciprocal and should be built on equal partnerships among U.S. scientists and scientists of developing nations. Examples of activities to be supported would include, but not be limited to: joint research projects; and long-term (1 year) or short-term (1-3 months) exchange visits that are reciprocal exchanges of investigators and students between the US and developing countries. Collaborations should be developed that bring complementary sets of expertise to bear on problems of importance to the participants from developing countries, and that meet their identified needs.

This is a Request for Information (RFI) issued by the U.S. Department of Energy (DOE) on behalf of the Advanced Materials and Manufacturing Technologies Office (AMMTO). The intent of this RFI is to solicit feedback from affected stakeholders on the EES2 Initiative in general and on the draft Microelectronics Energy Efficiency Scaling for 2 Decades (EES2) Research, Development, and Demonstration (RD&D) Roadmap that accompanies this RFI. The EES2 roadmap focuses on the energy efficiency of computing and the computing stack. Therefore, we have divided our roadmap into eight specialized working groups, each focusing on specific layers of the computing stack or on enabling technologies and approaches. Working group deliberations focused on identifying key emerging, energy-efficient technologies and their challenges and solutions. The EES2 working groups for version 1.0 are: a. Materials and Devices (MnD) b. Circuits and Architectures (CnA) c. Advanced Packaging and Heterogenous Integration (APHI) d. Algorithms and Software (AnS) e. Power and Control Electronics (PaCE) f. Manufacturing Energy Efficiency and Sustainability (MEES) g. Metrology and Benchmarking (MnB) h. Education and Workforce Development (EWD) Responses to this RFI must be submitted electronically to [email protected] no later than 5:00pm (EDT) on September 30, 2024. Responses must be provided as a Microsoft Word (.docx) attachment to an email. It is recommended that attachments with file sizes exceeding 25MB be compressed (i.e., zipped) to ensure message delivery. This RFI is not accepting applications for financial assistance or financial incentives. EERE may or may not issue a Funding Opportunity Announcement (FOA) based on consideration of the input received from this RFI. Please see the full RFI document for additional information.

The purpose of the NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00) program is to develop and maintain a strong cohort of independent dentist scientists. This program is designed to facilitate a timely transition of outstanding dual degree dentist scientists from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions by providing support for two years of mentored training and three to five years of independent research. The option for five years of independent (R00) support is available to accommodate clinical training in a dental specialty program at no more than 3 person-months effort (25% effort) in any year of the R00 phase.

The Operations Engineering (OE) program supports fundamental research on advanced analytical methods for improving operations in complex decision-driven environments. Analytical methods include, but are not limited to, deterministic and stochastic modeling, optimization, decision and risk analysis, data science, and simulation. Methodological research is highly encouraged but must be motivated by problems that have potential for high impact in engineering applications. Application domains of particular interest to the program arise in commercial enterprises (e.g., production/manufacturing systems and distribution of goods, delivery of services), the public sector/government (e.g., public safety and security), and public/private partnerships (e.g., health care, environment and energy). The program also welcomes operations research in new and emerging domains and addressing systemic societal or technological problems. The OE program particularly values cross-disciplinary proposals that leverage application-specific expertise with strong quantitative analysis in a decision-making context. Proposals for methodological research that are not strongly motivated by high-potential engineering applications are not appropriate for this program. PIs are encouraged to send any program inquiries to both Program Directors.

USAID Vietnam intends to issue a Cooperative Agreement for USAID/ Vietnam's Combating Illegal Wildlife Trafficking activity. The anticipated dollar range for the five-year activity is between $14 and $16 million. Attached is the draft Program Description (PD) of the activity. We invite your comments/feedback to this draft PD. Any responses should be submitted to Ms. Huyen Dang at [email protected] not later than 9:00 Hanoi time, November 23, 2020 and all responses will be considered prior to finalizing the PD. Please be advised that this is not a Request for Applications (RFA) and does not constitute a commitment on the part of the US. Government to make an award. We anticipate releasing the Request for Applications (RFA) at the end of November, 2020 with a closing date for receipt of applications in mid-January of 2021.  We look forward to receiving your comments/feedback. Thank you very much for your time and interest in the activity.  

The Facility andInstrumentationRequest Process (FIRP)solicitation describes themechanismby which the research community can propose projects that require access toinstrumentation and facilities sponsored by theFacilitiesfor Atmospheric Researchand Education(FARE) Programin theDivision of Atmospheric andGeospaceSciences (AGS). FARE provides funding to a variety of organizations to make specialized instrumentation and facilities available to the atmospheric science research communitythrough the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF) programs. FIRP allows for parallel evaluation of intellectual merit and broader impacts along with the feasibility of the proposed project. All proposals to AGS that require the use of FARE-sponsored assets must be submitted through this solicitation. The FIRP solicitation offers three proposal submission tracks based on the type and purpose of the request: Track 1-Education and Outreach. Track 2-Single Facility Request. Track 3-Field Campaigns. Preference for funding will be given to proposals submitted to programs in the DivisionofAtmospheric andGeospaceSciences (AGS) in the Geosciences Directorate (GEO).If you are planning to submit a proposal to a program outside AGS, including NSF-wide or Directorate-wide solicitations, please contact the FARE program director, Shree Mishra at [email protected] to discuss the timelines, review process, andbudget request for the use of FARE assets.

The Division of Mathematical Sciences (DMS) in the Directorate for Mathematical and Physical Sciences (MPS) at the National Science Foundation (NSF) and the Air Force Office of Scientific Research (AFOSR) plan to jointly support foundational mathematical and statistical research on Digital Twins in applied sciences. Recent years have witnessed a significant increase in the demand and interest in applications that involve collaborative teams developing and analyzing Digital Twins to support decision making in various fields, including science, engineering, medicine, urban planning, and more. Both agencies recognize the need to promote research aiming to stimulate an interplay between mathematics/statistics/computation and practical applications in the realm of Digital Twins. This program encourages new collaborative efforts within the realm of Digital Twins, aiming at stimulating fundamental research innovation, pushing, and expanding the boundaries of knowledge, and exploring new frontiers in mathematics and computation for Digital Twin development, and its applications. By leveraging this synergy, the program aims to harness science, technology, and innovation to address some of our Society’s most pressing challenges.

Submit application as necessary.

This program element does not have a proposal due date. Proposals may be submitted at any time, pending certain eligibility timing issues related to resubmissions and duplicate proposal avoidance, see the program element text and appropriate overview appendix (e.g., B.1 or C.1). The date shown of 3/28/2025 is the last day that proposals may be submitted subject to the ROSES-24 rules and the current Guidebook for Proposers. The ROSES-25 version of this program element is planned to overlap with this ROSES-24 version by a few weeks, allowing continuous submission of proposals across ROSES years. | Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package.   The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) – 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024.   This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.8 Lunar Data Analysis Program (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.pdf)” from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview.    Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list.   Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar). 

(Reissue PAR-21-057) The purpose of this Program Announcement (PAR) is to enable analytical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of analytical methods for biomarker measurements, including evaluation of the detection method, its performance characteristics, and the optimal conditions that will generate reproducibility and accuracy consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed, and 3) the research and/or clinical need and potential context of use has been identified.

With this solicitation, the Division of Chemistry is piloting the removal of deadlines for the submission of proposals to the CLP, CSD and CTMC Programs. The no-deadline pilot seeks to assess the benefits and challenges of removing deadlines in proposal submission for the chemistry research community: the removal of deadlines on proposal submission is intended to allow principal investigators (PIs) more flexibility and better facilitate interdisciplinary research. It may, however, have unanticipated consequences for PIs, reviewers, and institutions. This solicitation applies only to the Chemistry of Life Processes (CLP), Chemical Structure and Dynamics (CSD), and Chemical Theory, Models and Computational Methods (CTMC) programs. Other than the following exceptions, all proposals submitted to the CLP, CSD, and CTMC programs must be submitted through this solicitation, otherwise they will be returned without review. Exceptions: Faculty Early Career Development Program (CAREER) proposals should be submitted through the CAREER solicitation (https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214) by the CAREER deadline date specified. | | Facilitating Research at Primarily Undergraduate Institutions: Research in Undergraduate Institutions (RUI) and Research Opportunity Awards (ROA) proposals should be submitted through the RUI/ROA solicitation (https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5518). In addition to the requirements of the RUI program, proposals should follow the guidance in this solicitation. Proposals submitted through the RUI/ROA solicitation to the CLP, CSD, and CTMC programs can be submitted at any time starting September 1, 2022. | | Proposals for Early-concept Grants for Exploratory Research (EAGER), Grants for Rapid Response Research (RAPID), Research Advanced by Interdisciplinary Science and Engineering (RAISE), and conferences can be submitted anytime after consultation with the cognizant NSF Program Officer. | | Supplemental funding requeststo existing grantscan be submitted anytime after consultation with the cognizant NSF Program Officer. |

This Funding Opportunity Announcement (FOA) encourages formative research, intervention development, and pilot-testing of interventions. Primary scientific areas of focus include the feasibility, tolerability, acceptability and safety of novel or adapted interventions that target HIV prevention or treatment. For the purposes of this FOA, intervention is defined to include behavioral, social, or structural approaches, as well as combination biomedical and behavioral, social, or structural approaches that prevent acquisition and transmission of HIV infection, or improve clinical outcomes for persons who are HIV infected, or both.

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

The intent of this funding opportunity is to award new or renewal grant awards to consortia consisting of Minority Serving Institution (MSIs) and Tribal Colleges and Universities (TCUs) to with a focus on building and supporting the workforce capacity of the National Nuclear Security Administration’s (NNSA) Nuclear Security Enterprise (NSE) by (1) expanding scientific and technical knowledge in the areas of Advanced Manufacturing, Cybersecurity, Engineering, or Nuclear Security, (2) providing experiential learning opportunities for students in Science, Technology, Engineering, and Mathematics (STEM) related disciplines, (3) building and strengthening research and education capacities of participating institutions, and (4) promoting collaborations with the NNSA NSE. The MSIPP Consortia Grant Program (MSIPP CGP) improves the Nation’s capacity to enhance national security by: • Growing the number of MSI and TCU students that graduate with STEM degrees • Increasing the number of MSI and TCU students hired into the NSE’s STEM workforce • Building and strengthening research and educational capacities of MSIs and TCUs • Targeting collaborations and increasing interactions between MSIs and TCUs, and DOE/NNSA laboratories, plants, and other sites to increase direct access to NSE STEM resources

This ISO seeks solution summaries and proposals for projects that fall within the general scope of the ARPA-H Scalable Solutions mission office. SSO expands what is technically possible by developing approaches that will leverage an interdisciplinary approach and collaborative networks to address challenges of geography, distribution, manufacturing, data and information, thereby improving health care access and affordability. In the United States, many communities and remote areas lack access to timely and quality health care, which leads to disparities in health outcomes for those populations. Bottlenecks during the manufacturing processes of products and health technologies also lead to delays and limited availability, preventing effective distribution of health care solutions to areas of need, especially in emergencies. | ARPA-H SSO seeks solutions to improve the scalability and affordability of health care solutions, bridge gaps in underserved areas, and extend remote access to expertise by developing location-specific interventions, telemedicine solutions, and mobile health clinics. Solutions should focus on rapid innovation and the use of partnerships, as well as flexible distribution networks and streamlined manufacturing processes. The following SSO interest areas categorize the ground-breaking solutions we seek to support: | Scalable Technologies and Interventions:• Approaches to improve affordability and equitable access to health care that are adaptable to various geographic, demographic, economic contexts and can be rapidly deployed at scale (e.g., drug-repurposing*, telemedicine, point-of-care diagnostics, and modular health care infrastructure).• Tailored solutions for the pediatric population that provide parity in access to treatments and other health care interventions with the adult population and adapt to the pediatric patient’s changing physiology and developmental status over the course of years.• Transformational approaches to reduce or eliminate health disparities, including tools and models for product design and care delivery that scale novel approaches in human factors and human-centered design to respond to full diversity of patients.• Tools to enable the scaling of provider and institutional capabilities (e.g., school nurses and schools, walk-in clinics, homesteading care) to address unmet health care access needs and expand availability of critical services.• Foundational capabilities to accelerate diagnoses and reduce the cost of treatments for rare diseases wherever patients are, without the need for specialized facilities or healthcare expertise.* Solution summaries and proposals that focus on testing drugs for effectiveness for other disease states or use cases, are unlikely to be funded unless including additional R&D, or providing gains in cost reduction, accessibility, and/or equity. | Collaborative Distribution Networks:• Methods for standardization, automation, and democratization of complex procedures 5 including, but not limited to, histopathology, rare disease diagnosis and treatment, and surgical interventions to ensure access and delivery to populations diverse in demographics, geographies, and resources at scale.• Approaches to enhance delivery of effective healthcare solutions in rural or low resource settings, including but not limited to "last mile delivery”, at-home monitoring, imaging, drug delivery, telehealth augmentation, and support for remote medical procedures with limited need for specialized training.• Technologies to enable the deployment of critical healthcare resources rapidly, equitably, and securely at scale to the point of need in permissive and non-permissive (i.e., damaged infrastructure, cyber-denied) environments during a public health crisis or natural disaster.• Solutions to scale education and training of critical healthcare resources for health care providers and patients to ensure information integrity to prevent negative impacts to resource use/uptake.• Innovative information technology, data and analytic products and technologies to enable ordering, inventory management, situational awareness, allocation planning and demand forecasting of critical healthcare resources during a public health crisis or natural disaster. | Biomanufacturing Innovations*:• Innovative manufacturing technologies and approaches that reduce cost, shorten the timeline for production, advance domestic competitiveness and reduce supply chain risk of biologics, cellular and gene therapies, pharmaceuticals, medical devices and personal protective equipment.• New approaches to support predictable, programable biological production of conventional and novel materials reliability at scale in a cost-effective sustainable manner.• Novel solutions to reduce the reliance on specialized handling and cold chain management of pharmaceuticals and biologics.• Scalable innovations to advance and strengthen biomanufacturing supply chain and resolve bottlenecks including:o Advances in production of active pharmaceutical ingredients, process consumables, and other critical materials (i.e., enzymes, cell lines, etc);o Novel biomanufacturing-related data products, technologies or models to integrate into supply chain situational awareness systems;o Alternative materials and new manufacturing capabilities for personal protective equipment; ando Improvement of capabilities sustainably re-shore manufacturing and utilize a broad array of readily accessible and cost-efficient feedstocks as part of strengthening the local and national industry base.• Analytics and novel sensor systems to precisely manage bioproduction, real-time release assays, and predictive capabilities to inform tuning of biological chassis for efficient and effective scale-up of manufacturing to industrial scale.*ARPA-H is not interested in approaches that merely increase capacity reservation. | Other high-quality submissions that propose revolutionary technologies that meet the goals of SSO will be considered even if they do not address the topics listed above. | Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease. | Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The U.S. Department of the Interior’s (Department) WaterSMART (Sustain and Manage America’s Resources for Tomorrow) Program provides a framework for Federal leadership and assistance to stretch and secure water supplies for future generations in support of the Department’s priorities. Through WaterSMART, the Bureau of Reclamation (Reclamation) leverages Federal and non-Federal funding to work cooperatively with States, Tribes, and local entities as they plan for and implement actions to increase water supply sustainability through investments in existing infrastructure and attention to local water conflicts. WaterSMART provides support for priorities identified in Presidential Executive Order 14008: Tackling the Climate Crisis at Home and Abroad (E.O. 14008) and aligned with other priorities, such as those identified in Presidential Executive Order 13985: Advancing Racial Equity and Support for Underserved Communities Through the Federal Government (E.O. 13985). The WaterSMART Small-Scale Water Efficiency Projects also support the goals of the Interagency Drought Relief Working Group established in March 2021 and the National Drought Resiliency Partnership. These grants will advance the Biden-Harris Administration’s Justice40 Initiative. Established by E.O. 14008, the Justice40 Initiative has it made it a goal that 40 percent of the overall benefits of certain federal investments flow to disadvantaged communities. Federal agencies are using the Climate and Economic Justice Screening Tool to help identify disadvantaged communities. The objective of this NOFO is to invite States, Indian Tribes, irrigation districts, water districts, and other organizations with water or power delivery authority to leverage their money and resources by cost sharing with Reclamation on small-scale on-the-ground projects that seek to conserve, better manage, or otherwise make more efficient use of water supplies. Proposed projects that are supported by an existing water management and conservation plan, System Optimization Review, or other planning effort led by the applicant are prioritized. This prioritization will help ensure that projects funded under this NOFO are well thought out, have public support, and have been identified as the best way to address water management concerns. Reclamation has simplified the evaluation criteria and streamlined the application process for this category of WaterSMART Grants to ensure that the process works for smaller entities. Simplified evaluation criteria are intended to provide each applicant with an opportunity to succinctly explain how the proposed project would meet a defined need identified through a prior planning effort.

The Advanced Technologies and Instrumentation for the Astronomical Sciences (ATI) program provides individual investigator and collaborative research grants for the development of new technologies and instrumentation for use in ground-based astronomy and astrophysics.The program supports achieving the science objectives of the Division of Astronomical Sciences. The development of innovative, potentially transformative, technologies and instruments are sought, even at high technical risk.Supported categories include (but are not limited to):advanced technology development, concept feasibility studies, and specialized instrumentation to enable new observations that are difficult or impossible to obtain with existing means.Proposals may include hardware and/or software development and/or analysis to enable new types of astronomical observations. Access to the ATI supported technology and instrumentation development efforts by the US astronomical community is viewed as an important metric of success. An annual Principal Investigators meeting is planned to disseminate information between the funded research efforts.

This Notice of Funding Opportunity (NOFO) invites applications for a Data Coordination Center (DCC) for the Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) Consortium at NIDA. The DCC will serve as the organizational hub for the management and sharing of TranSINDA data and build a modern data ecosystem that integrates the data repository under common data standards and serves as a resource for software tools for large scale data query, analysis, visualization, and integration. The DCC will also facilitate coordination for the TranSINDA consortium, and address policy issues related to data sharing and use.

Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information.   For the addresses for obtaining and submitting an application, please refer to our Common Instructions for Applicants to Department of Education Discretionary Grant Programs, published in the Federal Register on February 13, 2019 (84 FR 3768), or at www.govinfo.gov/​content/​pkg/​FR-2019-02-13/​pdf/​2019-02206.pdf. |            The Project SAFE grant program is intended to improve students’ safety and well-being by providing resources to local educational agencies (LEAs) that adopt and implement strategies to prevent the spread of the Novel Coronavirus Disease 2019 (COVID-19) consistent with guidance from the Centers for Disease Control and Prevention (CDC) and that are financially penalized for doing so by their State educational agency (SEA) or other State entity.  |            Purpose of Program: The Project SAFE grant program provides grants to eligible LEAs to improve student safety and well-being by advancing strategies consistent with CDC guidance to reduce transmission of COVID-19 in schools. |            To submit an application, please email the completed and signed application, along with required attachments, to [email protected]. The application template may be found at the following link: https://oese.ed.gov/offices/office-of-formula-grants/safe-supportive-schools/the-project-to-support-americas-families-and-educators-project-safe/              Assistance Listing Number (ALN): 84.184N

Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package.   The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) – 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024.   This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on “C.8 Lunar Data Analysis Program (.pdf)” to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read “C.1 Planetary Science Research Program Overview (.pdf)” from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview.    Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list.   Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar). 

This Funding Opportunity Announcement (FOA) supports research from creative early stage investigators who propose highly innovative, pioneering studies with potential to open new areas of HIV/AIDS related to coinfections, comorbidities, and complications. Projects should reflect new and novel scientific directions that are distinct from concepts and approaches being pursued in the investigators research program or elsewhere. Projects must be consistent the scientific priorities outlined by the NIH Office of AIDS Research (OAR). These priorities have been most recently been described in NOT-OD-20-018.

The Greening Youth Foundation (GYF) for the purpose of hiring four GYF Interns to support the research, programming, and dissemination of knowledge regarding the key African-American figures in National Capital Parks- East.

Through this Notice of Funding Opportunity (NOFO), the National Institutes of Health (NIH) aims to facilitate the career development and transition of investigators new to entrepreneurship with an interest in small business by simultaneously supporting their entrepreneurial development and the conduct of research and development under their direction. This NOFO supports small business concerns (SBCs) in employing and developing researchers as entrepreneurial Program Directors/Principal Investigators (PDs/PIs). In addition to augmenting scientific research staff and supporting research and development efforts at SBCs, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Optimal PDs/PIs for this award are scientists and professionals with strong research, technology development, and/or healthcare delivery skills and experience, but limited entrepreneurial and independent research project leadership experience. PDs/PIs are expected to grow their entrepreneurial skillset while working in a small business to develop promising technologies and products that align with NIH's mission to improve health and save lives.

Communities in the United States (US) and around the world are entering a new era of transformation in which residents and their surrounding environments are increasingly connected through rapidly-changing intelligent technologies. This transformation offers great promise for improved wellbeing and prosperity but poses significant challenges at the complex intersection of technology and society. The goal of the NSF Smart and Connected Communities (S&CC) program solicitation is to accelerate the creation of the scientific and engineering foundations that will enable smart and connected communities to bring about new levels of economic opportunity and growth, safety and security, health and wellness, accessibility and inclusivity, and overall quality of life. For the purposes of this solicitation, communities are defined as having geographically-delineated boundaries—such as towns, cities, counties, neighborhoods, community districts, rural areas, and tribal regions—consisting of various populations, with the structure and ability to engage in meaningful ways with proposed research activities. A “smart and connected community” is, in turn, defined as a community that synergistically integrates intelligent technologies with the natural and built environments, including infrastructure, to improve the social, economic, and environmental well-being of those who live, work, learn, or travel within it. The S&CC program encourages researchers to work with community stakeholders to identify and define challenges they are facing, enabling those challenges to motivate use-inspired research questions. For this solicitation, community stakeholders may include some or all of the following: residents, neighborhood or community groups, nonprofit or philanthropic organizations, businesses, as well as municipal organizations such as libraries, museums, educational institutions, public works departments, and health and social services agencies. The S&CC program supports integrative research that addresses fundamental technological and social science dimensions of smart and connected communities and pilots solutions together with communities. Importantly, this program is interested in projects that consider the sustainability of the research outcomes beyond the life of the project, including the scalability and transferability of the proposed solutions. This S&CC solicitation will support research projects in the following categories: S&CC Integrative Research Grants (SCC-IRG) Tracks 1 and 2. Awards in this category will support fundamental integrative research that addresses technological and social science dimensions of smart and connected communities and pilots solutions together with communities. Track 1 proposals may request budgetsranging between $1,500,001 and $2,500,000, with durations of up to four years. Track 2 proposals may request budgetsup to $1,500,000, with durations of up to three years. S&CC Planning Grants (SCC-PG). Awards in this category are for capacity building to prepare project teams to propose future well-developed SCC-IRG proposals. Each of these awards will provide support for a period of one year and may be requested at a level not to exceed $150,000 for the total budget. S&CC is a cross-directorate program supported by NSF’s Directorates for Computer and Information Science and Engineering (CISE), Education and Human Resources (EHR), Engineering (ENG), and Social, Behavioral, and Economic Sciences (SBE).

The Louis Stokes Alliances for Minority Participation (LSAMP) program invests in the Nation's colleges and universities to aid student success to create a new generation of STEM discoverers for the national STEM enterprise. The program takes a comprehensive approach to the STEM Learning Ecosystem to impact STEM student development and retention. LSAMP is an alliance-based program, whereby a group of institutions of higher education (IHEs) work together to diversify the nation's science, technology, engineering, and mathematics (STEM) workforce by increasing the number of STEM baccalaureate and graduate degrees awarded to persons from LSAMP populations. LSAMP populations are defined as persons from groups underrepresented in the STEM enterprise: Blacks and African-Americans, Hispanic and Latino Americans, American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders. The LSAMP program provides funding to alliances that implement comprehensive, evidence-based, innovative, and sustained strategies that ultimately result in the graduation of well-prepared, highly competitive students from LSAMP populations who pursue graduate studies or careers in STEM, while also supporting knowledge generation, knowledge utilization, assessment of program impacts, dissemination activities and dissemination of scholarly research into the field. Projects supported by the LSAMP program include: --Alliance Development Grants (ADG) support the conceptualization and development of new B2B and new SPIO alliances. (New) --Bridge-to-the-Baccalaureate (B2B) alliances facilitate the successful transfer of students from LSAMP populations to four-year institutions in pursuit of STEM baccalaureate degrees. --STEM Pathways Implementation-Only (SPIO) alliances are designed for new and reconstituted alliances. These projects focus on building and strengthening strategies and approaches to assist Institutions of Higher Education (IHEs) increase STEM baccalaureate degrees to LSAMP populations and facilitate entry into STEM graduate degree programs. --STEM Pathways Research Alliances (SPRA) are designed for well-established alliances. These projects serve as models of excellence in STEM broadening participation by (1) steadily increasing STEM baccalaureate degrees to LSAMP populations and facilitating entry into STEM graduate degree programs; (2) producing and disseminating new scholarly research on the broadening participation of LSAMP populations (or underrepresented and underserved populations in STEM disciplines and the nation's STEM workforce) and, (3) holistically assess the state of institutionalization and sustainability of the alliance. --Bridge to STEM Graduate Degrees in National Priorities (BD-Master's) projects support cohorts of six graduate students pursuing a M. S. degree in STEM national priority areas, providing financial support (stipends and cost of education) and support to help develop and maintain academic and research skills that enable participants to successfully persist in STEM graduate degree programs at Master's comprehensive-degree producing institutions only. (New) --Bridge to STEM Graduate Degrees in National Priorities (BD-Doctoral) projects support cohorts of twelve graduate students pursuing a Ph.D. degree in STEM national priority areas, providing financial support (stipends and cost of education) and support to help develop and maintain academic and research skills that enable participants to successfully persist in STEM doctoral degree programs. --STEM Networking Incentives and Engagement (NETWORKS) projects provide support to incentivize the creation and participation of LSAMP populations in STEM networks. (New)

The Sea Duck Joint Venture (SDJV) is a conservation partnership under the North American Waterfowl Management Plan (NAWMP). Its mission is to promote the conservation of North American sea ducks by providing greater scientific knowledge and understanding of sea duck biology and ecology to support effective management. The SDJV is composed of Federal and state/provincial wildlife agencies in Canada and the U.S., as well as non-governmental organizations and other entities committed to sea duck conservation. SDJV projects are accomplished through efficient public/private partnerships and cooperative funding. The SDJV is coordinated and administered by the United States Fish and Wildlife Service (USFWS) and the Canadian Wildlife Service. Primary funding is provided to the SDJV through U.S. Congressional appropriations; some of this funding is made available through competitive grants to solicit partnerships that can address priority science needs of the SDJV. This funding opportunity is made under the authority of Fish and Wildlife Act of 1956; 16 U.S.C. 742. SDJV funding supports both the USFWS and Department of Interior (DOI) missions, and the DOI Secretary’s priorities related to conservation stewardship and protection. One of the purposes of the SDJV is to prevent further listings of sea duck species under the U.S. Endangered Species Act (ESA), as two sea duck populations are already listed as threatened in the U.S., and two are listed as species of concern under the Species at Risk Act (SARA) in Canada. Funded projects contribute sound science about sea duck populations and habitat needs that contribute to monitoring their status and addressing factors that diminish their abundance. Healthy sea duck populations support traditional harvests of sea ducks that are important for subsistence hunters in rural northern communities, and waterfowl hunting opportunities for hunters in the U.S. and Canada, particularly in coastal areas of the Atlantic, Great Lakes, and Pacific regions. The Sea Duck Joint Venture (SDJV) is requesting proposals that directly address the following research priorities. Proposals focused on SDJV high priority species are preferred. SDJV considers the following species high priority because of the magnitude of information needs of each given an assessment of available information and predicted current/future stressors: Common Eider, King Eider, White-winged Scoter, Black Scoter, Surf Scoter, Harlequin Duck, Long-tailed Duck, and Barrow’s Goldeneye.Research Priorities (not listed in order of importance):1. Information on migratory connectivity of sea ducks to improve survey design, harvest management and development of conservation actions. New studies could target geographic gaps from previous satellite telemetry studies or analyze existing datasets. Priorities include but are not limited to large-scale projects that provide information on population delineation (Pacific vs. Atlantic) for species where populations overlap, and projects focusing on priority sea duck species, particularly Long-tailed Ducks and King Eiders.2. Studies that use Indigenous Knowledge to inform broad questions about sea duck ecology and management related to SDJV priorities. Projects that are co-produced with Indigenous partners are encouraged.3. Studies focused on estimating rates of fecundity and survival of priority sea duck species. Modeling studies that identify and/or address information gaps, and studies refining alternative methods such as using photographic surveys to estimate sex and/or age ratios, are encouraged. Large-scale projects focused on investigating factors that influence these demographic parameters and provide information to inform harvest estimates and population-level management decisions will be prioritized.4. Projects that characterize habitat use of priority species. Desired products include but are not limited to (a) estimates of energetic demands or time activity budgets for molting or wintering sea ducks to inform future estimates of landscape carrying capacity and (b) habitat suitability models. Projects that directly contribute to management or conservation of key sites identified in the Sea Duck Key Habitat Sites Atlas are encouraged. 5. Studies to determine effects of anthropogenic activities on sea duck populations. This may include (a) evaluation of the effects of industrial development (e.g., wind energy, mariculture, oil and gas development, vessel traffic, sand mining, contaminants) on sea ducks, and/or (b) development and testing of potential methods to reduce negative effects of these activities on sea ducks.6. Studies that evaluate and predict effects of climate change on sea ducks, including changes in northern breeding areas and coastal habitats, altered phenology of life history patterns, changes in food resources and predator communities, and other conditions that degrade or enhance productivity and survival.7. Evaluations of the effects of disease or parasites on sea duck populations.8. Studies that improve our understanding of the viewpoints of various stakeholders in sea duck conservation to inform conservation and management actions. This could include an assessment of the values, concerns and behaviors of birdwatchers, the waterfowl management community, habitat joint ventures, hunters, hunting guides/outfitters, Indigenous communities and organizations, and other groups.9. Studies that provide estimates of the size and composition of general and subsistence sea duck harvest such that the information could be incorporated into population models and management plans. This may include assessments of the derivation and distribution of sea duck harvest and how harvest is changing over time.10. Assessments of the effect of changing predator communities (e.g., bald eagle, polar bear, mink, fox) on sea duck foraging behavior, breeding success, diurnal and long-term distribution patterns, and the effects of potential distribution shifts on the interpretation of survey data from long-term monitoring studies.11. The development of new techniques or technologies that advance our ability to address the research priorities above.Interested applicants are strongly encouraged to contact the SDJV Coordinators and JV associates in advance of submitting proposals to ensure that they understand the specific nature of the issues and consider advice on previous scientific work. More information on the SDJV’s previous work, strategies, and priorities is outlined in plans, reports, and products archived at seaduckjv.org.

The U.S. Embassy Kuala Lumpur Public Affairs Section (PAS) of the U.S. Department of State is pleased to announce that funding is available through its Public Diplomacy Small Grants Program. This is an Annual Program Statement, outlining our funding priorities, the strategic themes we focus on, and the procedures for submitting requests for funding. | PAS Kuala Lumpur invites proposals for programs that strengthen ties between the U.S. and Malaysia through cultural and exchange programming that highlights shared values and promotes bilateral cooperation. All programs must include an American cultural element, or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policy and perspectives.

The purpose of the Landscape Scale Restoration competitive grant program is to encourage collaborative, science-based restoration of priority rural forest landscapes. This program supports high impact projects that lead to measurable outcomes on the landscape, leverage public and private resources, and further priorities identified in science-based restoration strategies. | This funding opportunity is for Federally recognized Tribes, Alaska Native Corporations/Villages, and Tribal organizations as defined in 25 USC 5304. For projects where the applicant is a nonprofit (not a Tribal organization), university, State agency, town, or county, view the funding opportunities for Northeast and Midwest, South, and West.

Biology has transformed science over the last century through discoveries that cross subdisciplines from the molecular to the organismal to the ecosystem level. While making great progress, biology has also slowly fragmented into subdisciplines, creating a dynamic tension between unifying principles and increasingly reductionist pursuits. The aim of this solicitation is to bring researchers together around the common goal of understanding how the processes that sustain life and enable biological innovation operate and interact within and across different scales of organization, from molecules to cells, tissues to organisms, species, ecosystems, biomes and the entire Earth. The Biology Integration Institutes (BII) program supports collaborative teams of researchers investigating questions that span multiple disciplines within and beyond biology. Integration across biological disciplines is essential if we hope to understand the diverse and ever-increasing data streams of modern biology and tackle emergent questions about living organisms and the environment. Of equal importance is the need for groundbreaking and sustainable training programs that prepare the next generations of scientists to navigate the breadth of biological sciences, training in multiple disciplines without sacrificing depth of learning or innovation. In addition, the biology community must continue to develop practices and adopt strategies that leverage rapid advances in cyberinfrastructure and other technologies to bridge and integrate across subdisciplines and make resources accessible, re-usable, and adaptable for unanticipated purposes. In these ways, Biology Integration Institutes will focus on biological themes that enable the discoveries of life’s innovations. The outcomes from biological integration will inspire new biotechnologies and applications to drive our bioeconomy and provide solutions to societal challenges. While this solicitation focuses on the integration of biological subdisciplines, any field beyond biology may be included as needed to address the overarching biological theme.

The Decision, Risk and Management Sciences Program (DRMS) supports scientific research directed at increasing understanding and effectiveness of decision making by individuals, groups, organizations and society. DRMS supports research with solid foundations in theories and methods of the social and behavioral sciences. This social and behavioral science research should advance knowledge, address fundamental scientific and societal issues and have strong broader impacts. DRMS funds disciplinary and interdisciplinary research, doctoral dissertation research improvement grants (DDRIGs) and conferences in the following areas: judgment and decision making; decision analysis and decision aids; risk analysis, perception and communication; societal and public-policy decision making; management science and organizational design. The program supports the use of the RAPID funding mechanism for research that involves ephemeral data, typically tied to disasters or other unanticipated events. Much less frequently, the program also supports highly unusual, proof-of-concept, high-risk projects that are potentially transformational (Early Concept Grants for Exploratory Research – EAGER). For detailed information concerning RAPID and EAGER grants, please review Chapter II.E of theNSF PAPPG. All research must be grounded in theory and generalizable. Purely algorithmic management-science proposals should be submitted to theOperations Engineering (OE)Program rather than to DRMS. Decision, Risk and Management Sciences offers Doctoral Dissertation Research Improvement Grants (DDRIGs) to improve the quality of dissertation research.For detailed guidelines on preparing a DDRIG proposal, consult the separateDRMS-DDRIG solicitation.

The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC) is soliciting investigator-initiated research to rigorously evaluate and examine effectiveness of strategies, programs, or policies (collectively referred to as “strategies”) for preventing polysubstance-impaired driving and associated crashes, nonfatal injuries, or deaths. Polysubstance-impaired driving means driving while impaired by two or more substances, such as alcohol and opioids or cannabis and alcohol. Comprehensive evaluations of strategies to prevent polysubstance-impaired driving are lacking and urgently needed given the changing landscape of substance use and impaired driving. Additionally, given inequitable impacts on some populations (American Indian and Alaska Native [AIAN] communities, rural populations, etc.), research is needed to examine strategy effectiveness among different populations. This NOFO supports research that can help fill these gaps. Research may include, but is not limited to, evaluation of the impact of any of the following on preventing polysubstance-impaired driving and related outcomes: 1) Evidence-based alcohol-impaired driving strategies that may also prevent polysubstance-impaired driving. Examples include, but are not limited to, screening and brief intervention and alternative transportation or transit programs. 2) Strategies that prevent excessive alcohol use, harmful substance use, or substance use disorders that have the capacity to also prevent polysubstance-impaired driving. Examples include, but are not limited to, taxation or pricing policies for alcohol and cannabis, social norming campaigns, and multi-component coalition-based strategies (e.g., Drug Free Communities Programs or similar efforts). This NOFO encourages examination of strategy effects on polysubstance-impaired driving and associated injuries and deaths among the overall population and disproportionately affected populations.

The FY24 VRP CTA supports the rapid implementation of early-phase clinical trials with the potential to have a significant impact on the treatment or management of service-connected eye injury and visual dysfunction.Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies.Funding from this award mechanism must support a clinical trial. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.Applicants seeking funding for research that does not meet this definition should consider one of the other FY24 VRP program announcements being offered.For more information, a Human Subject Resource Document is provided at https://cdmrp.health.mil/pubs/pdf/Human%20Subjects%20Resource%20Document_DEC2022.pdfFor the purposes of this funding opportunity, Regulatory Agency refers to the U.S. Food and Drug Administration (FDA) or any relevant international Regulatory Agency unless otherwise noted.If the proposed clinical trial involves the use of a drug that has not been approved by the relevant Regulatory Agency for the country where the research will be conducted, then submission of an Investigational New Drug (IND) application, or equivalent, that meets all requirements under 21 CFR 312 may be required. It is the responsibility of the applicant to provide evidence from the Institutional Review Board (IRB) of record or the relevant Regulatory Agency if an IND, or equivalent, is not required. If an IND, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency by the FY24 VRP CTA application submission deadline. In addition, applicants must provide documentation of communication from the Regulatory Agency indicating that the IND, or equivalent, is active/safe to proceed by March 1, 2025, in order for the FY24 VRP CTA application to be considered for funding. Refer to Attachment 10: Regulatory Strategy for further details. The IND, or equivalent, should be specific for the product and indication to be tested in the proposed clinical trial. For more information on IND applications specifically, the FDA has provided guidance at https://www.fda.gov/drugs/types-applications/investigational-new-drug-ind-application.If the investigational product is a device, then submission of an Investigational Device Exemption (IDE) application, or equivalent, that meets all requirements under 21 CFR 812 may be required. It is the responsibility of the applicant to provide evidence if an IDE, or equivalent, is not required. If an IDE, or equivalent, is required, the regulatory application must be submitted to the relevant Regulatory Agency by the FY24 VRP CTA application submission deadline. In addition, applicants must provide documentation of communication from the Regulatory Agency indicating that the IDE, or equivalent, is active/safe to proceed by March 1, 2025, in order for the FY24 VRP CTA application to be considered for funding. Refer to Attachment 10: Regulatory Strategy for further details. The IDE, or equivalent, should be specific for the device and indication to be tested in the proposed clinical trial.The proposed clinical trial is expected to begin no later than 6 months after the award date.

Three eligible nonprofit organizations for a total of five years to assist the agency in establishing and conducting an Experienced Services Program. Under this program, the USFWS will enter into cooperative agreements with private nonprofit organizations designated by the Secretary of Labor as eligible to receive funds under Title V of the Older Americans Act of 1965 to recruit and utilize the skills and experience of older Americans, aged 55 and older. Authorizing Statutes: Consolidated Appropriations Act, 2019 (P.L. 116 6, Division E, Sec. 113). Program activities will be carried out under various authorities, including: Endangered Species Act (16 U.S.C. 1531 et seq.); Fish and Wildlife Act (16 U.S.C. 742 et seq.); Fish and Wildlife Coordination Act (16 U.S.C. 661 666e); Fish and Wildlife Improvement Act (16 U.S.C. 753); Migratory Bird Treaty Act (16 U.S.C. 703 et seq.)

The Academy of Kidney Cancer Investigators (AKCI) is a unique, interactive virtual academy that provides, intensive mentoring, national networking, and a peer group for scientist and clinician junior faculty. The KCRP created the Academy of Kidney Cancer Investigators in FY19 to align with several program priorities, which include to build research capacity in kidney cancer; increase collaborations to advance kidney cancer research, and support innovative research conducted by the next generation of kidney cancer scientists and clinicians. The overarching goal of the AKCI is to increase research capacity in kidney cancer through the development of successful, highly productive kidney cancer researchers in a collaborative research and training environment. The AKCI is a virtual career development and research training platform that currently consists of 11 Early-Career Scholars (ECS)/Designated Mentor pairs from different institutions, and one Academy Director. It is expected that six Early-Career Scholars will graduate by the fall of 2025 and four FY23 AKCI – Early-Career Scholars/Designated Mentor awards will be made by September 2024. In addition, Academy graduates will continue to participate in the annual Academy meetings. Information about the Academy is available on the KCRP webpage and in the Kidney Cancer Program Booklet at https://cdmrp.health.mil/kcrp. The AKCI leadership team will identify opportunities for engagement with KCRP AKCI Scholars-Designated Mentors and KCRP FY25 (and subsequent year awardees) Postdoctoral and Clinical Fellowship Awardees. The Academy Director and Deputy Director catalyze the growth and professional development of the Early-Career Scholars in collaboration with their Designated Mentors, assess the progress of the ECSs, and facilitate communication and collaboration among all of the Academy members. The AKCI leadership team will also identify and offer opportunities for engagement (e.g., invitations to seminar series and in-person meetings) with FY24 Postdoctoral and Clinical Fellowship Awardees with FY24 KCRP AKCI-ECS-Designated Mentors (and subsequent year awardees). This FY24 funding opportunity is soliciting applications for an Academy Director (Principal Investigator [PI]) and Deputy Director (Partnering PI) to lead the AKCI. The newly selected FY24 Academy Director and Deputy Director will initiate their responsibilities no later than October 2025. The Academy Director and Deputy Director (hereafter referred to as Academy Leadership) must be established kidney cancer researchers and can be at different institutions. The Academy Leadership must demonstrate a strong record of mentoring and training earlycareer investigators, a commitment to leadership, the ability to articulate methods toward research collaborations, and the ability to objectively assess the progress of all Scholars with their Designated Mentors in the AKCI. Other objectives will include execution of research that will engage AKCI FY24 Scholars (including subsequent-year Scholars), develop tools for Scholars to enable success, and provide opportunities to broaden their knowledge in kidney and renal pelvis cancers. The leadership team will identify and offer occasion(s) for the AKCI to network with KCRP FY24 Postdoctoral and Clinical Fellowship Awardees (and subsequent year awardees). Designated Mentors on FY24 KCRP AKCI – Early-Career Scholar Award applications and Designated Mentors on open FY19 through FY23 KCRP AKCI – Early-Career Scholar Awards (with the exception of those graduating in 2024) are not eligible to apply for this award. Note: An invited oral presentation is a requirement for application review of the KCRP AKCI – LA, as described in Section II.D.2.b.iv, Additional Application Components. Responsibilities of the Academy Leadership include, but are not limited to: • Act as a resource for all Scholars and Designated Mentors in the Academy over the Scholars’ 4-year period of performance. • Facilitate communication and collaboration among all Scholars and Designated Mentors (including periodic interactive communication among all Academy members). • Develop assessment criteria to evaluate the research progress made by all Scholars, as well as their career progression and sustainment as independent investigators in kidney cancer research. • Conduct collaborative kidney cancer pilot project(s) that include Academy Scholars. These pilot projects should have the potential to improve collaboration within the Academy, as well as impact kidney cancer research and/or kidney cancer patients/survivors. o Examples of pilot research projects may include but are not limited to (a) funding an extended statistical or bioinformatics analysis with AKCI Scholars, (b) performing a large-scale meta-analysis of human or animal datasets with AKCI scholars, (c) provide access to critical biorepositories or animal models to expand AKCI investigator analyses or increase study rigor. • Provide constructive critiques with the goal of advancing the research and professional careers of the Scholars and strengthening the mentorship of the Designated Mentors. • Provide avenues to increase the promotion of the Academy and visibility of Scholars within kidney cancer research and advocacy communities (e.g., peer review, conferences, editorial boards). • Support the professional development, to include laboratory management skills, of the Scholars into leading researchers through invited presentations by experts outside of the AKCI – LA. • Plan and host an annual 1-day workshop and, biennially, a multi-day workshop for all Scholars/Designated Mentor pairs as well as Academy graduates to present their research, share knowledge, and develop collaborative efforts within the AKCI. Scholars will be responsible for their own travel costs to in-person Academy meetings. • Include KCRP FY24 Postdoctoral and Clinical Fellowship Awardees in at least one meeting of the FY24 AKCI. These investigators will be responsible for their own travel costs, funds for which are included in their research awards. • Establish a panel of patient advocates and Veteran(s) (i.e., the Patient Advocacy Panel) to inform the AKCI on the needs of the patient community.  • Establish the Designated Mentor Panel to facilitate collaborations among the AKCI participants including the Scholars, Academy Director/Deputy Director, and the Designated Mentors. The Academy of Kidney Cancer Investigators – Leadership Award is structured to support two PIs. The Academy Director will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Deputy Director will be identified as the Partnering PI. The collaboration between the Academy Director and the Deputy Director should be supported by complementary expertise and experience. Initiating and Partnering PIs each have different submission requirements, as described in Section II.D.2, Content and Form of the Application Submission; however, both PIs should contribute significantly to the development of the proposed research project. The application should clearly demonstrate that both PIs have equal levels of input on the proposed Academy Leadership and clearly define the components to be addressed by each to support the success of the Scholars. While it is up to the Academy Director and the Deputy Director to define their roles, both Academy Leaders should have interactions with each Scholar-Designated Mentor pair, (and the Scholars’ Designated Mentors); acting as administrative support does not fulfill the intent of the Director and Deputy Director. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI(s), refer to Section II.D.2, Content and Form of the Application Submission. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Women’s Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women’s health outcomes and/or advancing knowledge for women’s health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Clinical trials are not allowed under this funding opportunity. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under §46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be cooperative agreements (31 USC 6305). Substantial CDMRP programmatic involvement with recipients is anticipated during the performance of award activities. Substantial involvement means that, after award, CDMRP staff will assist, guide, coordinate, or participate in project activities including but not limited to: • Participating in the Steering Committee that oversees study conduct. • Make recommendations for continued funding based on (a) overall study progress, including sufficient patient and/or data accrual; (b) cooperation in carrying out the research (e.g., attendance at Steering Committee meetings, implementation of group decisions, compliance with the terms of award and reporting requirements); and/or (c) maintenance of a high quality of research. The anticipated combined direct costs budgeted for the entire period of performance for a FY24 KCRP AKCI – LA should not exceed $1,500,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.4M to fund approximately one KCRP Academy of Kidney Cancer Investigator Leadership Award application (consisting of an Initiating PI application and a Partnering PI application). Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 and FY26 funds, which will expire for use on September 30, 2030, and September 30, 2032, respectively.