Funding Opportunities In Us

Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)

The purpose of this Notice of Funding Opportunity (NOFO) is to support exploratory and conceptual research projects in radiation research focused on medical countermeasures, biodosimetry, and animal model development to diagnose/mitigate/treat injuries arising from radiation exposure during a public health emergency. This NOFO is intended to support development of preliminary data to help advance high-risk, high-reward projects needed for a robust early product development pipeline that can lead to the advancement of much-needed radiation-exposure related tools and products.

The long-range goal of the Research Training Groups in the Mathematical Sciences (RTG) program is to strengthen the nation's scientific competitiveness by increasing the number of well-prepared U.S. citizens, nationals, and permanent residents who pursue careers in the mathematical sciences, be they in academia, government, or industry. The RTG program supports efforts to improve graduate student research training and professional development through structured groups pursuing collaborative research. In addition to graduate student trainees working with faculty members, RTG supported research teams may, but are not required to, include undergraduate or postdoctoral trainees. The RTG program invites submissions in all fields within mathematical sciences; especially encouraged in 2024-2025 are those that align and integrate research in mathematics and statistics with emerging areas such asArtificial Intelligence, Biotechnology,Quantum Computing, and Cybersecurity.

The purpose of this notice of funding opportunity (NOFO) is to enhance the sustainability and impact of research software tools by enabling the use of best practices and design principles in software development and by leveraging continuing advances in computing. It is also expected to facilitate the creation of vibrant partnerships between developers and users of software and tools, and to promote FAIR practices for research software to maximize research value.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that bundle independent protocols for phase 1 clinical trials with phase 1b/phase 2a clinical trials to streamline the early-stage evaluation of promising pharmacological interventions for Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD). Candidate interventions evaluated through this program, which can include small molecules or biologics for example, must engage non-amyloid/non-tau mechanisms and aim to address cognitive and/or neuropsychiatric symptoms in individuals across the spectrum from pre-symptomatic to more severe stages of disease. This NOFO uses the UG3/UH3 phased award mechanism and proposals must include prespecified, go/no-go safety and tolerability milestones that gate the advance from phase 1 to latter stages of clinical development.

The National Endowment for the Humanities (NEH) Division of Preservation and Access is accepting applications for the National Digital Newspaper Program. This program creates a national digital resource of historically significant newspapers published between 1690 and 1963 from all 56 states and U.S. jurisdictions. The Library of Congress (LOC) maintains this freely accessible, searchable online database.

This funding opportunity announcement (FOA) encourages Small Research Grant (R03) applications to facilitate the entry of investigators to the area of neuroimaging, including both new investigators and established investigators seeking to adopt neuroimaging methodologies in their research programs, to enable the conduct of small "proof of concept" studies. The R03 is intended to support research projects that can be carried out in a short period of time with limited resources.

This notice of funding opportunity (NOFO) invites grant applications for the Research Specialist Award (R50) specifically for clinician scientists supporting NCI-funded clinical trials research. The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional clinician scientists who want to continue to participate in the NCI clinical trials networks through leadership in the 1) development of national clinical trials, 2) implementation of NCI clinical trials in their institutions, and 3) national service to the NCI clinical trials networks through participation in the scientific review committees, monitoring committees and other activities, but not serve as principal investigators of research project grants. These clinician scientists are vital to sustaining the NCI-funded clinical trials enterprise. The Research Specialist Award is intended to provide salary support and sufficient autonomy so that individuals are not solely dependent on NCI grants held by others or other sources of support for cancer research career continuity.

This Funding Opportunity Announcement (FOA) supports Small Business Innovation Research (SBIR) applications from small business concerns (SBCs) that propose the development of therapeutic agents for the treatment of alcohol use disorder (AUD) and/or alcohol associated organ damage (AAOD). As a starting point, eligible applicants must identify a therapeutic candidate with a robust body of background data in the basic science and early discovery phases to be ready for transition to the preclinical and clinical phases of development. Data may include having sufficient bioactivity, stability, manufacturability, bioavailability, in vivo efficacy and/or target engagement, and other favorable properties that are consistent with the desired clinical application. Projects responsive to this announcement could be undertaken at any point along the drug development continuum, from late discovery (i.e., lead optimization/early safety) up to early-stage clinical trials. For small molecules, the earliest stage of eligibility for this Award is already having small-molecule compounds with proof of desired pharmacological activity. For biologics, the profiling of promising product candidates in animal models of AUD or AAOD will be allowed as the earliest entry point. The ultimate purpose and goal of this FOA is to advance molecules closer to U.S. Food and Drug Administration (FDA) approval. Milestones will be commensurate with the project proposed and the purpose of this FOA. This FOA supports early-phase clinical trials, although these are not required. Women-owned and Small Disadvantaged small business are encouraged to apply.

Pursuant to the Foreign Assistance Act of 1961, as amended, the United States Government, as represented by the U.S. Agency for International Development (USAID), the Bureau for Development, Democracy, and Innovation (DDI) , Natural Environment Branch, Biodiversity Division, (DDI/NE/Biodiversity) and supporting Bureaus, is announcing the Biodiversity Annual Program Statement (APS), hereafter known as the Biodiversity APS. Through this APS, USAID aims to implement the vision and goals of the Biodiversity Policy (2014) to: | 1. Conserve biodiversity in priority places, and 2. Integrate biodiversity as an essential component of human development. | The Biodiversity APS disseminates information to prospective Applicant(s) so they may develop and submit Concept Note(s) in response to individual Addenda issued under this APS and ultimately to be considered for USAID funding. This APS describes and provides information on: the type of activities for which Concept Note(s) will be considered; available funding, process and requirements for submitting Concept Note(s) and Full Application(s); the merit review criteria for evaluating Concept Note(s); and refers prospective Applicant(s) to relevant documentation and resources. | USAID’s DDI’s NE/Biodiversity Division and supporting Bureaus anticipate awarding multiple assistance awards as there is no predefined minimum or maximum number of awards expected to be issued under this APS. Issuance of the Biodiversity APS does not constitute an award or commitment on the part of the U.S Government (USG) to make an award, nor does it commit the U.S. Government to pay for costs incurred in the preparation and submission of a Concept Note and/or Full Application(s). The actual number of assistance awards, if any, is subject to the availability of funds and the interests and requirements of Mission/Bureau/Independent Office (M/B/IOs), as well as the viability of eventual Full Application(s). | The Biodiversity APS is not a Request for Applications (RFA). Rather, the Biodiversity APS requests Concept Notes in response to Individual Addenda published to this APS. Based on the submitted Concept Note(s) to specific Addenda opportunities, USAID will determine whether to request a Full Application from an eligible organization. To be competitive under an Addendum to this umbrella APS, Concept Notes and Full Applications must be fully responsive to all directions under this APS except when specifically noted otherwise in the Addendum. | |

This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for implementation of investigator-initiated, high-risk clinical trials and mechanistic studies associated with high-risk clinical trials. Mechanistic work in clinical trials may be of great value because it promotes the understanding of human diseases and the development of future therapeutic modalities. Investigators are encouraged to visit the NIAID website for additional information about the research mission and high-priority research areas of the NIAID (https://www.niaid.nih.gov/research/role). Only one clinical trial may be proposed in each NIAID Clinical Trial Implementation Cooperative Agreement (U01) application

The NEI uses UG1 cooperative agreement awards to support investigator-initiated large-scale clinical trials, human gene-transfer, stem cell therapy trials, and other complex or high resource- or safety-risk clinical trials. These projects are multifaceted and of high public health significance requiring clear delineation of study organization including roles and responsibilities and require careful performance oversight and monitoring. For purposes of this Notice of Funding Opportunity (NOFO), the proposed study must be intended to evaluate interventions aimed at screening, diagnosing, preventing, or treating vision disorders, or to compare the effectiveness of two or more established interventions. The NEI UG1-supported studies are typically funded as a group of single-component companion grant awards including the Chairs Grant, the Coordinating Center, and Resource Centers, when appropriate. Specifically, this NOFO encourages applications for the Resource Center grant which provides imaging, laboratory, or other requisite services for a multi-center clinical trial or other complex or high-risk clinical trial.

The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution. This NINDS K22 is specifically designed to facilitate the transition of NINDS intramural neurologist- and neurosurgeon-scientists to independent, academic faculty positions that support clinician-scientists to engage in independently funded scientific research as well as clinical activities.

To facilitate fundamental research in the atmospheric sciences, the Division of Atmospheric and Geospace Sciences (AGS) supports state-of-the-art instruments and facilities through the Facilities for Atmospheric Research and Education (FARE) Program. The FARE Program includes the Lower Atmosphere Observing Facilities (LAOF) and the Community Instruments and Facilities (CIF). Lower Atmospheric Observing Facilities The National Science Foundation (NSF) Division of Atmospheric and Geospace Sciences (AGS)Lower Atmospheric Observing Facilities (LAOF) Program oversees a portfolio of multi-user national facilities that are sponsored by NSF for use by the geosciences research community. Program management resides within AGS in the NCAR and Facilities Section (NFS) which provides a single point for coordination of planning and resources. | | The LAOF program enables geoscience research through the provision of specialized facilities, instrumentation, and field support services necessary to carry out the scientific field work associated with investigations of a wide range of geophysical phenomena. The program is actively involved in oversight of LAOF facilities and decisions about the acquisition, operation, maintenance, upgrading and replacement of these facilities based on input from the scientific community. LAOF funding supports both the planning for scientific field programs (e.g., experimental design, operational plans, logistical support) and the deployment of NSF-sponsored facilities. Proposals to the LAOF program are acceptedby invitation only. Please contact the FARE program director if you intend to submit a proposal to this program. Community Instrumentation and Facilities (CIF) The CIF program provides the NSF-sponsored atmospheric sciences research community with access to specialized instrumentation for field and laboratory-based studies.The program requests proposals from instrument and facility providers who will make their equipment available for community use through an NSF-defined request process.Support will be provided for limited technician time, minor upgrades, and travel for outreach.

The Leading Culture Change through Professional Societies of Biology (BIO-LEAPS) program aims to advance diversity, equity, and inclusion in the biological sciences broadly by leveraging the leadership, broad reach, and unique ability of professional societies to create culture change in the life sciences. The Directorate for Biological Sciences at the National Science Foundation (NSF BIO) recognizes that culture change in the biological sciences is an urgent priority because it is foundational to increasing diversity, equity, and inclusion in the discipline. The culture of a scientific discipline —defined here as the shared values, norms, traditions, and practices —can be thought of as an emergent property that results from years of experiences and interactions among scientists, their institutions, their professional societies, and their networks. It is increasingly recognized that the perceptions and attitudes of that culture can be quite variable for different individuals and are often negative for individuals historically excluded from the sciences (e.g., based on gender, gender identity, disability status, sexual orientation, ethnicity, race, the intersections of these, and others). Therefore, this program is designed to foster the necessary culture change within biology to move towards an equitable and inclusive culture that supports a diverse community of biologists that more fully reflects the demographic composition of the US population. Professional societies are uniquely positioned to help facilitate culture change in their disciplines through: publishing journals, fostering scientific discussion and debate, broad membership (including membership from academia, government agencies, and private businesses), hosting large scientific meetings that can serve as networking and professional development opportunities for people at many professional levels, and electing leaders that greatly influence views and norms within a discipline. Recognizing that culture change in biology will require broad, sustained, and innovative approaches for meaningful and lasting changes to occur, society leaders will need to enable and support the establishment and definition of new norms and practices in biology and to encourage engagement with experts in diversity, equity, and inclusion-related organizational change. NSF BIO will support awards that leverage the work of professional societies towards facilitating necessary culture change in the biological sciences to advance diversity, equity, and inclusion at scale — In other words, at the broad and deep scales that are required to address this systemic issue. Examples of evidence-based work that will be supported through this program include (but are not limited to): (1) creating transparent norms and practices that engender and support a sense of belonging and identity for diverse scientists from all backgrounds and demographics; (2) mitigating the systemic factors that result in inequities in the biological sciences, such as the perception of who a "scientist" is, and any factors that discourage diverse participation in biology; (3) assessing the state of norms and practices in professional societies and/or the other components and institutions within their disciplines; and, (4) planning, implementing, and assessing society-sponsored activities to change culture— such as safe conference best practices, strategies to mitigate implicit bias in hiring/promotion for society leadership positions, diversification of editorial boards, etc.

(Reissue of PAR-18-617) The purpose of this funding opportunity announcement (FOA) is to provide a vehicle for Small Business Concerns (SBCs) submitting Small Business Technology Transfer (STTR) grant applications for investigator-initiated exploratory clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). The projects must focus on products related to the mission and goals of the NINDS and may evaluate drugs, biologics, devices, or diagnostics, as well as surgical, behavioral or rehabilitation therapies. Only STTR Phase II and Fast-Track applications are supported under this program. STTR Phase I applications are only accepted as part of a Fast-track application.

This FOA will support creative educational activities that focus primarily on research skills development. . Although activities focused primarily on mentoring activities or professional skills development are not within the scope of this funding announcement, the informal mentoring activities and professional skills development that are usually associated with courses for research skills development are permitted.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites U01 cooperative agreement applications for Physical Sciences-Oncology Network (PS-ON). The goal of the PS-ON is to foster the convergence of physical sciences approaches and perspectives with cancer research to advance our understanding of cancer biology and oncology by forming transdisciplinary teams of physical scientists and cancer biologists/physician scientists. Examples of physical scientists may include engineers, physicists, mathematicians, chemists, and computer scientists. The research projects funded through this FOA, individually and as a collaborative Network along with other funded research projects, will support transdisciplinary research that: (1) drives a physical sciences perspective within the cancer research community; (2) facilitates team science and field convergence at the intersection of physical sciences and cancer research; and (3) collectively tests physical sciences-based experimental and theoretical concepts of cancer and promotes innovative solutions to address outstanding questions in cancer research.

The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. Other ICs use the K01 to support career development in specific fields.

The purpose of this Notice of Funding Opportunity (NOFO) is to support research that improves understanding of basic mechanisms and biomarkers of trained immunity (i.e., innate immune memory), plus the functional implications of trained immunity, related to 1) immune system development and function, 2) immunity to vaccines or natural infections, or 3) allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation.

The YouthPower 2 Annual Program Statement (APS) provides a vehicle for engaging with youth-led and youth-serving organizations, among others, and systems to generate cross-sectoral, positive youth development outcomes. The APS disseminates information to prospective Applicants so they may develop and submit Concept Notes in response to the addenda and ultimately to be considered for USAID funding. This APS describes and provides: ▪         The types of activities for which Concept Notes and Applications will be considered; ▪         Available funding, process, and requirements for submitting Concept Notes and Application; ▪         The criteria for evaluating Concept Notes and Application; and ▪         Relevant documentation and resources. | More specifically, the YouthPower 2 (YP2) APS is designed to provide a vehicle to engage with, among others, youth-led and youth-serving organizations and systems broadly and creatively, to support cross-sectoral, positive youth development outcomes.  | The YP2 APS is not a Request for Applications (RFA). Rather, the YP2 APS requests Concept Notes in response to addenda published under this APS. Based on the submitted Concept Note(s) in response to active addenda under this APS, USAID will determine whether to request a Full Application from an eligible organization. Concept Note(s) and/or Full Application to the APS will not be accepted. | USAID’s DDI Bureau Center for Education and supporting Bureaus anticipate awarding multiple grants and/or cooperative agreements as there is no predefined minimum or maximum number of awards.  | Please search grants.gov for current YP2 addenda opportunity Senegal - Access to Education 72068524APS00001 closing April 30, 2024 and Youth Open Geospatial Data Activity (YODA) 7200AA20APS00007-ADDENDUM closing May 6, 2024. | | | |

Data science is an important cross-cutting research approach in the 2022 - 2026 NIDA Strategic Plan and increasing the capacity of experts in addiction related data science is critical. The purpose of this Notice is to facilitate the entry of investigators to the area of addiction-related data science, including newly independent data scientists or established investigators seeking to incorporate novel and cutting-edge data science methodologies into their research programs for the first time. Through this opportunity, investigators will propose to apply emerging data science methods to answer critical questions requiring advanced data analytic strategies. Projects should be small in scale and answer specific research questions or provide preliminary data for a larger scale project. Applicants are encouraged to use existing datasets, follow FAIR principles, and, when applicable, attend to ethical concerns in the conduct of research involving human subjects. Ultimately, the aim is to expedite the development of robust research programs focused on the convergence of innovative data science techniques and addiction research, with initial projects serving as precursors for subsequent, more expansive research projects.

Under this APS, the United States Agency for International Development (USAID) Office of U.S. Foreign Disaster Assistance (OFDA) will consider applications for the development and dissemination of Supporting Emergency Agriculture Design and Standards (SEADS). Applicant Eligibility Information for this award is described in Section C of this Notice of Funding Opportunity (NFO). Subject to the availability of funds, USAID intends to award a single Cooperative Agreement to a responsible applicant whose application best meets the objectives of this funding opportunity and the selection criteria contained herein. USAID reserves the right to fund one or more or none of the applications submitted.

Critical Facility Energy Resilience (CiFER) This Funding Opportunity Announcement (FOA) will fund the advancement of innovative storage technologies from early-stage R&D to widespread commercialization and deploy an innovative energy storage technology at a host site with identified resiliency needs at the required scale, performance, and technology maturity level appropriate to advance technology maturity level appropriate to advance technology towards commercialization.

The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and "protected time" for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion FOA ().

This Funding Opportunity Announcement (FOA) is to provide support for research Centers that (1) conduct drug abuse and addiction research in any area of NIDAs mission, (2) have outstanding innovative science, (3) are multidisciplinary, thematically integrated, synergistic, and (4) serve as national resource(s) to provide educational and outreach activities to drug abuse research communities, educational organizations, the general public, and policy makers in the NIDA research fields. It is expected that a Center will transform knowledge in the sciences it is studying. Incremental work should not be the focus of Center activities; rather, new and creative directions are required. The P50 Center of Excellence is expected to foster the career development and mentoring of new investigators who would be given meaningful roles to play in the Center projects. A goal of this program is to create NIDA Centers that are national community resources for furthering drug abuse research by sharing their findings, their data, and their resources as appropriate for researchers to use and build upon and to advance research in this field.

With this solicitation, BJA will fund five training and technical assistance (TTA) providers to support grantees in the Office of Justice Programs’ (OJP) Community Violence Intervention and Prevention Initiative (CVIPI) and to provide supplemental funding to one site based grantee selected through this program in FY2024. OJP’s CVIPI seeks to prevent and reduce violent crime in communities by supporting comprehensive, evidence-based violence intervention and prevention programs, including efforts to address gang and gun violence based on partnerships among community residents, local government agencies, victim service providers, community-based organizations (CBOs), law enforcement, hospitals, researchers, and other community stakeholders. CVIPI is an OJP initiative, and BJA and its partners reviewed and recommended applications for funding in FY2022 and FY2023. In FY2022, the OJP awarded three national TTA providers under two national training and technical assistance-oriented categories: 6 and 7; and awarded three intermediary awards who will support training and technical assistance as well as provide funding to community-based organizations to enhance local or capacity of CVI organizations in category 5. In FY2023, BJA made additional awards including partially funding a state level award to the State of Illinois. OJP did not have sufficient funding to fully fund this recommended award and noted its plan in the approved FY23 CVIPI funding recommendations memo to provide the remaining funding with FY2024 funding.

The U.S. Department of the Interior’s (Department) WaterSMART (Sustain and Manage America’s Resources for Tomorrow) Program provides a framework for Federal leadership and assistance to stretch and secure water supplies for future generations in support of the Department’s priorities. Through WaterSMART, the Bureau of Reclamation (Reclamation) leverages Federal and non-Federal funding to support stakeholder efforts to stretch scarce water supplies and avoid conflicts over water. | Through the Title XVI Water Reclamation and Reuse Program (Title XVI), authorized by P.L. 102-575 in 1992, Reclamation provides financial and technical assistance to local water agencies for the planning, design, and construction of water reclamation and reuse projects. Water recycling is a tool in stretching the limited water supplies in the Western United States. Title XVI projects develop and supplement urban and irrigation water supplies through water reuse, thereby improving efficiency, providing flexibility during water shortages, and diversifying the water supply. These projects provide growing communities with new sources of clean water which increases water management flexibility and makes our water supply more reliable. | Through the Large-Scale Water Recycling Program, Reclamation will provide up to 25 percent (%) Federal cost share, with no per-project Federal funding maximum, to water recycling projects that have a total project cost greater than or equal to $500 million. Large-scale water recycling projects will play an important role in helping communities develop local, drought-resistant sources of water supply by turning currently unusable water sources into a new source of water supply that is less vulnerable to drought and climate change. The Large-Scale Water Recycling Projects funding opportunity provides support for priorities identified in Presidential Executive Order (E.O.) 14008: Tackling the Climate Crisis at Home and Abroad and is aligned with other priorities, such as those identified in E.O. 13985: Advancing Racial Equity and Support for Underserved Communities Through the Federal Government. In particular, the Large-Scale Water Recycling Projects funding opportunity advances the Biden-Harris Administration’s Justice40 Initiative. Established by E.O. 14008, the Justice40 Initiative has made it a goal that 40 percent of the overall benefits of certain federal investments, such as climate, clean energy, and other areas, flow to disadvantaged communities. | |

The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to support a cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible outstanding postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM.

The Artificial Intelligence, Formal Methods, and Mathematical Reasoning (AIMing) program seeks tosupport research at the interface of innovative computational and artificial intelligence (AI) technologies and new strategies/technologies in mathematical reasoning to automate knowledge discovery. Mathematical reasoning is a central ability of human intelligence that plays an important role in knowledge discovery. In the last decades, both the mathematics and computer science communities have contributed to research in machine-assisted mathematical reasoning, encompassing conjecture, proof, and verification. This has been in the form of both formal methods and interactive theorem provers, as well as using techniques from artificial intelligence. Recent technological advances have led to a surge of interest in machine-assisted mathematical reasoning from the mathematical sciences, formal methods, and AI communities. In turn, advances in this field have potential impact on research in AI.

(Reissue of PAR-18-486, PAR-21-153) The purpose of the NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) is to diversify the pool of independent neuroscience research investigators by providing junior faculty with research cost support, protected research time and career stage appropriate professional development mentorship in neuroscience research. Individuals from backgrounds underrepresented in biomedical research are eligible for support under this award if they have doctoral research degrees (Ph.D. or equivalent) and are in the first 3 years of a faculty tenure track or equivalent position at the time of application. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. NINDS will only accept applications to this FOA that propose human mechanistic trials/studies that meet NIH's definition of a clinical trial and that fall within the NINDS research priorities. Applicants are strongly advised to consult with NINDS program staff prior to submitting an application with human subjects to determine the appropriate funding opportunity.

The purpose of this Funding Opportunity Announcement (FOA) is to develop clinical-grade prototypes intended for use as safe, effective, and non-addictive device-based technologies and approaches to treat pain. The goal of the program is to demonstrate treatment using credible neural targets for device-based interventions and/or diagnostics for pain, building upon the latest mechanistic knowledge about the anatomy and physiology of central, spinal, and peripheral pathways involved in pain. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare for approvals for human use.

The NIDA Avant-Garde Award Program for HIV/AIDS Research supports individual scientists of exceptional creativity who propose high-impact research that will open new areas of HIV/AIDS research relevant to drug abuse and/or lead to new avenues for prevention and treatment of HIV/AIDS among drug abusers. The term avant-garde is used to describe highly innovative approaches that have the potential to be transformative. The proposed research should reflect approaches and ideas that are substantially different from those already being pursued by the investigator or others and should support the NIH HIV/AIDS Research Priorities https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-018.html. The NIDA Avant-Garde award supports innovative, basic research that may lead to improved preventive interventions or therapies; creative, new strategies to prevent disease transmission; novel approaches to improve disease outcomes; and creative approaches to eradicating HIV or improving the lives of those living with HIV.

The program in Geometric Analysis supports research on differential geometry and its relation to partial differential equations and variational principles; aspects of global analysis, including the differential geometry of complex manifolds and geometric Lie group theory; geometric methods in modern mathematical physics; and geometry of convex sets, integral geometry, and related geometric topics. Conferences Proposals for conferences, workshops, summer/winter schools, and similar activities must be submitted through the program solicitation "Conferences and Workshops in the Mathematical Sciences" (link below) and list Geometric Analysis as the program of interest. Principal Investigators should carefully read the solicitation and relevant sections of the PAPPG to obtain important information regarding the substance of such proposals and note the additional requirements for travel support requests for international events. For these types of proposals with budgets not exceeding $50,000, which in accordance with NSF policy can be reviewed internally at NSF, the following target dates are in effect: For events that will take place between March and August in a given year, proposals should be submitted in September of the previous year. For events that will occur between September in a given year and the last day of February in the following year, the proposal should be submitted in April prior. Proposals with budget requests that exceed $50,000 are likely to require external review, and hence are subject to longer processing time. These should be submitted roughly seven months before the event is scheduled to take place.

CMMT supports theoretical and computational materials research in the topical areas represented in DMR's other Topical Materials Research Programs (these are also variously known as Individual Investigator Award (IIA) Programs, or Core Programs, or Disciplinary Programs), which are: Condensed Matter Physics (CMP), Biomaterials (BMAT), Ceramics (CER), Electronic and Photonic Materials (EPM), Metals and Metallic Nanostructures (MMN), Polymers (POL), and Solid State and Materials Chemistry (SSMC). The CMMT program supports fundamental research that advances conceptual understanding of hard and soft materials, and materials-related phenomena; the development of associated analytical, computational, and data-centric techniques; and predictive materials-specific theory, simulation, and modeling for materials research. First-principles electronic structure, quantum many-body and field theories, statistical mechanics, classical and quantum Monte Carlo, and molecular dynamics, are among the methods used in the broad spectrum of research supported in CMMT. Research may encompass the advance of new paradigms in materials research, including emerging data-centric approaches utilizing data-analytics or machine learning. Computational efforts span from the level of workstations to advanced and high-performance scientific computing. Emphasis is on approaches that begin at the smallest appropriate length scale, such as electronic, atomic, molecular, nano-, micro-, and mesoscale, required to yield fundamental insight into material properties, processes, and behavior, to predict new materials and states of matter, and to reveal new materials phenomena. Approaches that span multiple scales of length and time may be required to advance fundamental understanding of materials properties and phenomena, particularly for polymeric materials and soft matter. Areas of recent interest include, but are not limited to: strongly correlated electron systems; topological phases; low-dimensional materials and systems; quantum and classical nonequilibrium phenomena, the latter including pattern formation, materials growth, microstructure evolution, fracture, and the jamming transition; gels; glasses; disordered materials, hard and soft; defects; high-temperature superconductivity; creation and manipulation of coherent quantum states; nanostructured materials and mesoscale phenomena; sustainable materials; polymeric materials and soft condensed matter; active matter and related collective behavior; biologically inspired materials, and research at the interfaces of materials with biological systems. CMMT encourages potentially transformative submissions at the frontiers of theoretical, computational, and data-intensive materials research, which includes but is not limited to: i) advancing the understanding of emergent properties and phenomena of materials and condensed matter systems, ii) developing materials-specific prediction and advancing understanding of properties, phenomena, and emergent states of matter associated with either hard or soft materials, iii) developing and exploring new paradigms including computational and data-enabled approaches to advance fundamental understanding of materials and materials related phenomena, iv) fostering research at interfaces among subdisciplines represented in the Division of Materials Research, v) harnessing machine learning or developing explainable machine learning to advance understanding of materials and materials-related phenomena, or vi) developing new theoretical frameworks in areas of materials research, such as active matter, nonequilibrium materials or matter, the synthesis of solid-state materials, or reformulating quantum many-body theory for conceptual insight or greater tractability. Research involving significant materials research cyberinfrastructure development, for example, software development with an aim to share software with the broader materials community, should be submitted to CMMT through Computational and Data-Enabled Science and Engineering (CDS&E) in accordance with its submission instructions for DMR. Additional Information Eligibility rules apply for submissions; please see Section II. Program Description, Section IV. Eligibility Information, and Section V.A Proposal Preparation Instructions.

This FOA provides support using the STTR cooperative agreement mechanisms for the development of novel extracellular vesicle-based therapeutic platforms for use in regenerative medicine. Both native and engineered EVs have demonstrated the ability for specific and targeted tissue and organ repair, which can be harnessed for applications such as extracellular vesicle-based therapeutics. The main objective for this funding opportunity is to support platform-oriented technology development associated with the production, manufacturing, and use, of extracellular vesicles as therapeutics in regenerative medicine.

The purpose of the Landscape Scale Restoration competitive grant program is to encourage collaborative, science-based restoration of priority rural forest landscapes. This program supports high impact projects that lead to measurable outcomes on the landscape, leverage public and private resources, and further priorities identified in each State Forest Action Plan or equivalent restoration strategy. Note: All applicants, except Federally recognized tribes, must have the relevant State Forester(s) sponsor the application. Submit a draft of the application narrative and budget spreadsheet to the relevant State Forester(s) (for where the work will be done) by COB September 27 (it is recommended that you reach out to the State Forester before this, as early as feasible). There is a separate request for proposals specifically for federally recognized Tribes and Alaska Native Corporations. This funding opportunity is for projects with on-the-ground outcomes across the 20 Northeast and Midwest States: CT, DE, IA, IL, IN, MA, MD, ME, MI, MN, MO, OH, NH, NJ, NY, PA, RI, VT, WI, and WV. Cross-regional projects are allowed (e.g., include work in States listed above as well as States to the South and/or West). For projects in other States, view LSR funding opportunities for the West and South.

The Mentored Career Transition Award for NIMH Intramural Fellows (K22) is a two-phase, mentored career development award program that is intended to facilitate a timely transition of qualified postdoctoral fellows in the NIMH Division of Intramural Programs (DIRP) from intramural postdoctoral research positions to extramural, academic tenure-track or equivalent faculty positions at eligible U.S. institutions. Both the intramural and extramural phases will be mentored, and the award will provide research support during the extramural phase to help awardees launch competitive, independent research programs. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion FOA (PA-18-NNN).

This FOA solicits innovative research to optimize HIV prevention and care which is aligned with NIMH Division of AIDS Research (DAR) priorities. Applications may include formative basic behavioral and social science to better understand a step or steps in the HIV prevention or care continuum, and/or the initial development and pilot testing of innovative intervention approaches, and intervention efficacy or effectiveness trials. Applicants are encouraged to read current Notices of Special Interests (NOSIs) from NIMH DAR for further information about the Divisions research priorities.

Teaching with Primary Sources Program (TPS) The Teaching with Primary Sources (TPS) program has been the Library of Congress’s premier educational outreach program. The goals of the program have included providing instructional materials, tools, education, and professional development that enhance teachers’ ability to integrate digitized primary sources from the Library of Congress into instruction that builds student literacy, critical thinking skills, content knowledge and ability to conduct original research. Since the establishment of the Center for Learning, Literacy and Engagement in 2018, and the release of the Library’s 2019-23 and 2024-2028 Strategic Plans, the TPS goals are both influencing and reflecting the Library’s broader outreach goals. TPS Consortium members are valued as “Connectors” who help the Library achieve its vision of connecting to all Americans. www.loc.gov/teachers | Additional Information about the TPS Regional Program In 2018, after a multi-year pilot, the Library formally incorporated the TPS Regional Program into the TPS Program. The Library currently has three Regional Partners – Waynesburg University, Illinois State University, and Metropolitan State University of Denver. They have offered subawards of between $5,000 and $25,000, on behalf of the Library, to educational organizations in the Eastern, Midwestern, and Western regions, respectively.   As of January 2024, Regional Partners have made subawards to 511 organizations in all 50 states, D.C., and Puerto Rico, to incorporate Library of Congress materials and TPS methods into their educational programming. Eligible awardee organizations include but are not limited to: K-12 school districts, libraries, universities, state departments of education, cultural institutions, foundations, non-profits, and community organizations.   Funded projects are diverse and tailored to the unique needs of learners in various communities. For example, subawards have provided resources for nonprofits to reach teachers working in a remote part of their states. They have helped local cultural institutions connect items in their holdings with digitized primary sources from the Library to provide learners with both a local and national view of important historical events. TPS regional awards have helped youth from ethnic minorities use Library resources to delve into their communities’ experience in America. | Notice of Funding Opportunity (NOFO) for Regional Awards With this notice, the Library seeks to solicit project proposals from organizations interested in becoming Regional Partners. The purpose of this notice is to identify awardee organizations to carry out all administrative and programmatic functions associated with managing TPS and LHI regional subawards on behalf of the Library of Congress. Awardee organizations must have the capacity, reputation, and relationships to conduct outreach and marketing to educators, operating in large and small communities, who wish to enhance their teaching programs with Library of Congress materials and pedagogical approaches.   Regional Partners must promote the program, solicit proposals for subawards, form proposal review panels, evaluate proposals, select recipients, distribute subawards, process subawards, monitor performance, close out subawards, and provide required narrative and financial reports to the Library of Congress. They must assist regional awardees in benefiting from association with the thousands of awardees, educators, and learners who make up the Library of Congress TPS community. Regional Partners must monitor educational trends in the states that they service and advise Library staff on the development of the overall TPS Regional Program. Further, Regional Partners must connect the Library to communities of educators and learners across the country with high-quality resources and teaching strategies.   Awardees must serve all states/territories in at least one designated region. Applicants may only select one (1) region from the list provided below: | Regions to be Served: Eastern Region: Connecticut, Delaware, District of Columbia, Maine, Maryland, Massachusetts, New Hampshire, New Jersey, New York, North Carolina, Pennsylvania, Rhode Island, Vermont, Virginia, West Virginia Midwest Region: Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, Ohio, Wisconsin Western Region: Alaska, Arizona, California, Colorado, Hawaii, Idaho, Nevada, New Mexico, Oregon, Texas, Utah, Washington Southern Region: Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, South Carolina, Tennessee Great Plains Region: North Dakota, South Dakota, Montana, Oklahoma, Wyoming U.S. Territories: American Samoa, Puerto Rico, Northern Mariana Islands, Guam, U.S. Virgin Islands | Submission Information All proposals must be submitted electronically via email to [email protected]. Proposals submitted through Grants.gov will not be accepted. | For full NOFO details, award project criteria, eligibility, and requirements, please view the Related Documents tab for this listing. | Amendments: August 21, 2024: The Proposal Narrative Template has been uploaded to the Related Documents section of the Notice in grants.gov. September 12, 2024: The Notice of Funding Opportunity has been amended and is uploaded to the Related Documents section of the Notice in grants.gov in order to reflect the following changes to the award requirements: Section A.2: The period for issuance and monitoring of subawards has been clarified. Additionally, awardees will only be required to convene one (1) meeting of regional sub-awardees per award period, rather than per calendar year. Section H.2.2: The Annual Implementation Plan has been changed to "Implementation Plan," due once per award period rather than once per calendar year.

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage revision applications (formerly called "competing revisions") from currently funded NCI P50 specialized centers. The applicants should propose to expand upon original research question(s) from specific projects or otherwise accelerate progress for the parent study by incorporating a new technical approach or instrument developed through support from the NCI Innovative Molecular Analysis Technologies (IMAT) program. Awards from this NOFO are meant to incentivize independent validation and accelerate the suitability of these emerging technologies for appropriate research communities. As a component of the NCI IMAT program, this NOFO aims to promote interdisciplinary collaboration in the development of innovative tools and methods that enable cancer research and accelerate scientific discovery.

The Office of Research Infrastructure Programs (ORIP) encourages research project grant applications aimed at developing and implementing broadly applicable technologies, tools, and resources for validating animal models and enhancing rigor, reproducibility, and translatability of animal research. Research projects submitted under this Funding Opportunity Announcement (FOA) should be hypothesis driven with strong preliminary data. Proposed studies, models, resources, or technologies under this FOA must either address research interests of multiple NIH Institutes and Centers (ICs), explore multiple organ systems, or be applicable to diseases and processes that impact multiple organ systems in order to align with ORIPs NIH-wide mission and programs. Applications should aim to enhance the rigor, reproducibility, and translatability of animal research through the development and implementation of technologies, tools, and resources that have significant impact across a broad range of research areas using animal models. Applications must demonstrate how the proposed resources and technologies impact rigor and reproducibility of animal studies.

The National Science Foundation (NSF), through the Directoratefor Engineering, the Directorate of Computer and Information Science and Engineering Division of Computer and Network Systems, and the Directorate for Mathematical and Physical Sciences Division of Materials Research, along with the U.S. Food and Drug Administration (FDA), through its Center for Devices and Radiological Health (CDRH), have established the NSF/FDA Scholar-in-Residence Program at FDA. This program comprises an interagency partnership for the investigation of scientific and engineering issues concerning emerging trends in medical device technology. This partnership is designed to enable investigators in science, engineering, and computer science to develop research collaborations within the intramural research environment at the FDA. Thissolicitation features three flexible mechanisms for support of research at the FDA: 1) Principal Investigators at FDA; 2) Postdoctoral Researchers at FDA; and 3) Graduate Students at FDA.

This Notice of Funding Opportunity (NOFO) invites applications from eligible research institutions to seek funds to build new or renovate existing facilities to expand the breeding capacity and increase future production of NIH-supported specific pathogen free (SPF) non-human primate (NHP) colonies. These SPF NHP facilities must support research activities aligned with the NIH-established priorities for HIV/AIDS research. Any request must be justified by current and anticipated future research needs of SPF NHPs.

The Archaeology Program administers an annual Archaeometry competition with a target date of December 1. The goal is to fund projects in two main categories: To develop or refine anthropologically relevant archaeometric techniques. Examples include the development of methods to identify specific types of organic residues on ceramics or development of field applicable analytic techniques. To support laboratories which provide relevant services. This includes support of service laboratories which, for example, may provide dating trace element, isotopic and dendrochronological analyses. It also includes support for data archives, which function to strengthen basic archaeological infrastructure. Projects which apply standard archaeometic techniques with the goal to answer specific archaeological questions should be submitted to the Archaeology SeniorResearch Awards competition. Proposals are evaluated by both ad hoc reviewers and a panel composed of individuals who combine both archaeological and archaeometric expertise.

The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICs) are issuing this R01 to solicit applications to address barriers and facilitators that impede use or uptake of cancer screening and preventive services in populations that experience health disparities. Interventions should include screening, preventive services, or other healthcare processes, including timely follow-up of abnormal findings, and referral to accessible care. Projects are encouraged to leverage collaborations with community partners and service providers. Interventions should address barriers and facilitators at two or more of the following levels: patient, clinician, healthcare setting, and neighborhood/community. Specific research interests of participating NIH ICs are detailed within.

This Notice of Funding Opportunity (NOFO) encourages grant applications from investigators interested in conducting basic, mechanistic research into the biological/genetic causes of cancer health disparities. These research project grants will support innovative studies designed to investigate biological/genetic bases of cancer health disparities, such as (1) mechanistic studies of biological factors associated with cancer health disparities, including those related to basic research in cancer biology or cancer prevention strategies, (2) the development and testing of new methodologies and models, and (3) secondary data analyses. This NOFO is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can expand available resources and tools, such as biospecimens, patient derived models, and methods that are necessary to conduct basic research in cancer health disparities.

This Notice of Funding Opportunity (NOFO) will support students at institutions with NIH-funded institutional predoctoral dual-degree training programs. The purpose of the Kirschstein-NRSA, dual-doctoral degree, predoctoral fellowship (F30) is to enhance the integrated research and clinical training of promising predoctoral students, who are matriculated in a combined MD/PhD or other dual-doctoral degree training program (e.g. DO/PhD, DDS/PhD, AuD/PhD, DVM/PhD), and who intend careers as physician/clinician-scientists. Candidates must propose an integrated research and clinical training plan and a dissertation research project in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. The fellowship experience is expected to clearly enhance the individual's potential to develop into a productive, independent physician/clinician-scientist. This Notice of Funding Opportunity (NOFO) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow candidates to propose research experience in a clinical trial led by a sponsor or co-sponsor.

The purpose of this FOA is to support research that addresses research questions relevant to human dental, oral, or craniofacial (DOC) diseases and conditions through analysis of existing and publicly available genomics data using data science approaches.

The Hydrologic Sciences Program is a disciplinary program within the Division of Earth Sciences. Hydrologic science has a distinct focus on continental water processes at all scales, and the program supports research with a primary focus on these processes. The program supports fundamental research about water on and beneath the Earth’s surface, as well as relationships of water with material and living components of the environment. A major focus is the study of hydrologic processes (e.g., rainfall and runoff; infiltration and subsurface flow; evaporation and transpiration), as well as fluxes of water (e.g. in soils, aquifers, and streams). Many projects involve the study of hydrologic transport (e.g., of dissolved solutes, sediment), coupling of hydrological processes with other systems (e.g., ecosystem processes, geochemical cycles, food and energy systems, socio-ecological systems), or hydrologic responses to change (e.g., changes in land use, climate, or watershed management). Observational, experimental, theoretical, and modeling approaches are supported.

Through the Broadening Participation in Engineering (BPE) Program, NSF seeks to strengthen the future U.S. engineering workforce by enabling and encouraging the participation of all citizens in the engineering enterprise. The BPE Program seeks to support not only research in the science of broadening participation and equity in engineering, but also collaborative endeavors which foster the professional development of a diverse and well-prepared engineering workforce as well as innovative, if not revolutionary, approaches to building capacity through inclusivity and equity within the engineering academic experience. To solicit the best ideas for these activities, both in formation and enactment, the BPE Program will support projects at various levels of readiness and complexity through the following four tracks: Planning and Conference Grants; Research in Broadening Participation in Engineering; Inclusive Mentoring Hubs (IMHubs); and Centers for Equity in Engineering (CEE). Specific details regarding these pathways can be found in the Program Description.

This Funding Opportunity Announcement (FOA) invites applications that employ integrative experimental and analytical approaches engaging basic and translational/clinical research aimed at developing a comprehensive understanding of the impact of sex differences on the trajectories of brain aging and disease, phenotypes of AD and AD-related dementias (ADRD) risk, individualized prevention, and responsiveness to pharmacologic and non-pharmacologic interventions. To this end, the central goal of this initiative is to develop robust research programs that will explore how genes, environment, and host factors such as hormonal status (gonadal and brain-derived) interact at various levels of biologic complexity (i.e., cell, tissue, organs/organ systems, and populations) to produce heterogeneous phenotypes of disease risk and responsiveness to prevention/therapy in AD/ADRD.

The overarching goal of this solicitation is to democratize access to NSF’s advanced cyberinfrastructure (CI) ecosystem and ensure fair and equitable access to resources, services, and expertise by strengthening how Cyberinfrastructure Professionals (CIP) function in this ecosystem. It aims to achieve this by (1) deepening the integration of CIPs into the research enterprise, and (2) fostering innovative and scalable education, training, and development of instructional materials, to address emerging needs and unresolved bottlenecks in CIP workforce development. Specifically, this solicitation seeks to nurture, grow and recognize the national CIP[1] workforce that is essential forcreating, utilizing andsupportingadvanced CI to enable and potentially transform fundamental science and engineering (S&E) research and education and contribute to the Nation's overall economic competitiveness and security. Together, the principal investigators (PIs), technology platforms, tools, and expert CIP workforce supported by this solicitation operate as an interdependent ecosystem wherein S&E research and education thrive. This solicitation willsupport NSF’s advanced CI ecosystem with a scalable, agile, diverse, and sustainable network of CIPs that can ensurebroad adoptionof advanced CI resources and expert services including platforms, tools, methods, software, data, and networks for research communities, to catalyze major research advances, and to enhance researchers' abilities to lead the development of new CI. The SCIPE program is led by the Office of Advanced Cyberinfrastructure (OAC) in the Directorate for Computer and Information Science and Engineering (CISE) and has participation from other NSF directorates/divisions, as described in Section II. Program Description,Programmatic Areas of Interest. Not all directorates/divisions are participating at the same level, and some have specific research and education priorities. The appropriate contact for the SCIPE program in any directorate/division is the Cognizant Program Officer (PO) for the respective directorate/division/office/program listed below. All projects are expected to clearly articulate how they address essential community needs, will provide resources that will be widely available to and usable by the research community, and will broaden participation from underrepresented groups.Prospective PIs arestrongly encouragedto contact the Cognizant Program Officers in CISE/OACandin the participating directorate/division relevant to the proposal to ascertain whether the focus and budget of their proposed activities are appropriate for this solicitation.Such consultations should be completed at least one month before the submission deadline. PIs should include the names of the Cognizant Program Officers consulted in a Single Copy Document as described in Section V.A. Proposal Preparation Instructions. The intent of the SCIPE program is to encourage collaboration between CI and S&E domain disciplines. (For this purpose, units of CISE other than OAC are considered domain disciplines.) To ensure relevance to community needs and to facilitate adoption, those proposals of interest to one or more domain divisionsmustinclude at least one PI/co-PI with expertise relevant to the targeted research discipline. All proposals shall include at least one PI/co-PI with expertise pertinent to OAC. Prospective PIs contemplating submissions that primarily target communities relevant to directorates/divisions that are not participating in this solicitation are directed to explore instead the education and workforce development programs of the respective directorates/divisions. [1] 9CI Professionals refers to the community of individuals who provide a broad spectrum of skills and expertise to the scientific and engineering research enterprise by inventing, developing, deploying and/or supporting research CI and CI users. Examples of CI Professionals include CI system administrators, CI research support staff, CI research software engineers, data curators, and CI facilitators, and may also include computational research scientists and engineers who are not in traditional academic paths.See:Transforming Science Through Cyberinfrastructure: NSF’s Blueprint forCyberinfrastructure Learning and Workforce Development,https://www.nsf.gov/cise/oac/vision/blueprint-2019/CI-LWD.pdf.

Amendment 2 (September 20, 2024): The purpose of this Amendment is to extend the Master Announcement Instructions (MAI) Closing Date from October 20, 2024 until December 31, 2024. All changes are highlighted in yellow. | Please see Amendment 2 attachment for further details. | Amendment 1 (June 25, 2024): The purpose of this Amendment 1 is to: 1) make administrative updates to Section 1.1, 1.2, 2.1.2, 3.1, 3.2 and 5.2.6; 2) replace Section 2.1.1 with new language pertaining to Federally Funded Research and Development Centers (FFRDCs) and Government Entities. Additionally, Section 4.2, Evaluation Criteria #2 is updated to remove the reference to Government Entities (removal is not highlighted in yellow); 3) change references from Abstract to Solution Summaries (intent behind the document is unchanged); 4) update proposal submission instructions in Section 3.2; and 5) update Section 5.1 to remove the Stage 2 Notification Letter. All changes are highlighted in yellow. | Also, please note that the title of this opportunity has bee revised to eliminate confusion. The opportunity should have been titled, "Master Announcement Instruction (MAI)" instead of "ARPA-H BDF Tool Box". | The Master Announcement Instructions (MAI) is a new ARPA-H announcement that aims to create standard tiered proposal submission requirements, so the amount of work required to write a proposal is commensurate with the size of the proposed effort. It also aims to reduce the up-front work required to submit cost information to reduce the barrier to entry for non-traditional performers. Module announcements that link to this MAI will provide more specific instructions about how the proposal requirements vary across tiers of effort. | All responsible sources capable of satisfying the Government’s needs may submit a proposal to a Module Announcement. Specifically, universities, non-profit organizations, small businesses and other than small businesses are eligible and encouraged to propose to Module Announcements. | NOTE: Proposals shall NOT be submitted against the MAI. Proposals shall only be submitted against a Module Announcement.  | |

This funding opportunity announcement (FOA) seeks to facilitate the entry of both newly independent and early career investigators to the area of drug use and use disorder research and HIV/AIDS. This FOA, the AIDS-Science Track Award for Research Transition (A-START), encourages Small Research Grant (R03) applications to support research projects on drug use and/or use disorder and HIV/AIDS that can be carried out in a short period of time with limited resources. This FOA welcomes applications integrating substance use and/or substance use disorder (SUD) and HIV/AIDS across all areas of research supported by NIDA.

The purpose of this Funding Opportunity Announcement (FOA) is to support applications for high-priority, regionally relevant infectious diseases research by international investigators in resource-constrained countries. Applicant organizations must be headquartered in foreign (non-U.S.) resource-constrained countries (i.e. low-income economies, lower-middle-income economies, and upper-middle-income economies by World Bank Classification). Applicant organizations headquartered in low- and lower-middle income economy countries are particularly encouraged to apply. Eligibility status of applicant organizations will be determined by the World Bank Classification list at the time of application submission.

This NOFO invites applications at the intersection of HIV and aging by proposing research that aims to meet the following objectives:1) Improve the understanding of biological, clinical, and socio-behavioral aspects of aging through the lens of HIV infection and its treatment; and2) Improve approaches for testing, preventing, and treating HIV infection, and managing HIV-related comorbidities, co-infections, and complications in different populations and cultural settings by applying current aging science approaches.Proposed research must be consistent with the HIV/AIDS Research Priorities outlined by NIHs Office of AIDS Research (OAR), as described inNOT-OD-20-018.

Executive Summary: The Embassy of the United States of America, Bishkek, announces an open competition to implement a program to support equal access to public services, educational institutions, and economic opportunities for all peoples, including minorities and marginalized groups. This program supports an inclusive society and vibrant, effective civic engagement by competitively awarding cooperative agreements to nonprofit, nongovernmental organizations (NGOs) and associations, civil society organizations (CSOs), educational institutions and independent local media organizations in the Kyrgyz Republic. Respect for others is a shared value between the Kyrgyz and American people, but understanding of and sensitivity toward diversity, equity, inclusion, and accessibility (DEIA) concepts remains limited in the Kyrgyz Republic. By promoting understanding of DEIA concepts, this project will advance U.S. foreign policy priorities to reduce discrimination and advance the human rights of historically marginalized groups. Background: The Public Diplomacy Section (PDS) of the U.S. Embassy in the Kyrgyz Republic is soliciting applications for cooperative agreements that focus on the requirements below. Applicants should pay close attention to PDS priority goal/s, program areas, target audiences, and geographic location when developing their proposals. The full proposal package comprises of six documents, including the narrative proposal template and the short budget proposal. The narrative proposal template cannot exceed three pages, otherwise the package will be disqualified from consideration. In addition, if the package does not contain the required six documents, it will be disqualified from consideration.  | Over the past year, PDS has implemented two initiatives focused on accessibility and promoting DEIA terminology in the Kyrgyz language: 1) DEIA Kyrgyz-language flashmob with local Kyrgyz-speaking social media influencers; and 2) Installation of the elevator specifically designed for wheelchair users. This funding opportunity seeks to support projects promoting respect for human rights in the Kyrgyz Republic. Potential projects may include, but not limited to: Expanding and popularizing DEIA terminology in the Kyrgyz language: Translating existing resources and DEIA-related vocabulary, developing educational materials. Engaging youth in DEIA initiatives: Developing innovative ways to promote DEIA values among the local youth. Integrating DEIA terminology into public discourse: Organizing workshops or events that introduce DEIA terminology and promote DEIA values in Kyrgyz in the public lexicon; Facilitating collaboration with Kyrgyz language experts: Organizing workshops and collaborative initiatives with the State Kyrgyz Language Committee and Kyrgyz language experts and language enthusiasts. | Project Goal: Increase support for equal access to services, educational institutions, and economic opportunities for all peoples, including minorities and marginalized groups, by promoting understanding of DEIA concepts. | Project Audience(s):  Primary Kyrgyz-speaking general public Kyrgyz speaking rural audience Underserved and vulnerable populations in rural regions Secondary Traditional and social media representatives Local ministries and state agencies  | Project Objectives: Project proposals may address one or more of these objectives or propose other objectives that support the goal above. Within 12 months: 1)  Raise awareness and understanding of DEIA concepts and terminology in Kyrgyz language among the rural Kyrgyz population 2)  Facilitate networking and collaboration between U.S. and Kyrgyz language state agencies and institutions to share best practices and develop joint strategies to promote DEIA concepts and principles through roundtables, networking events, and other initiatives. 3)  Equip at least 20 journalists, bloggers, influencers, and content creators with the ability to create media content that amplifies DEIA concepts and principles of inclusion.

USAID/ Vietnam intends to issue a Cooperative Agreement for USAID/ Vietnam's Reducing Pollution activity. The anticipated period of performance of this activity is five years. | Attached is the draft Program Description (PD) of the activity. We invite your comments/feedback to this draft PD. Any responses should be submitted to Ms. Huyen Dang at [email protected] not later than 9:00 Hanoi time, December 29, 2020 and all responses will be considered prior to finalizing the PD. | Please be advised that this is not a Request for Applications (RFA) and does not constitute a commitment on the part of the US. Government to make an award. We anticipate releasing the Request for Applications (RFA) at the end of December, 2020 with a closing date for receipt of applications in mid-February of 2021.  | We look forward to receiving your comments/feedback. Thank you very much for your time and interest in the activity. 

This Notice of Funding Opportunity (NOFO) invites applications proposing innovative strategies to target and manipulate brain cell subtypes that are altered in aging, Alzheimer's Disease (AD), and AD-Related Dementias (ADRDs). ADRDs include frontotemporal disorders (FTD), Lewy body dementia (LBD), vascular contributions to cognitive impairment and dementia (VCID), and multiple etiology dementias (MED). Specifically, the goal of the NOFO is to encourage the development and utilization of sophisticated tools that pair breakthroughs in adeno-associated virus (AAV) capsid engineering with enhancer element identification to (1) optimize precise targeting of disease-relevant cell subtypes in aged and degenerating mammalian brains and (2) monitor and/or manipulate these cells in vivo to address mechanistic hypotheses related to brain aging and AD/ADRD in animals models. To achieve this goal, the NOFO utilizes the R61/R33 Exploratory/Developmental Phased Award activity code. The R61 phase provides up to 2 years of support for pilot activities to demonstrate proof-of-principle. The R33 phase provides up to 3 years of support for implementation activities including hypothesis testing.

More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance in the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed. Through targeted research efforts, the NIH HEAL Initiative aims to support the development of safe and effective devices to treat pain with little or no addiction liability. This funding opportunity announcement (FOA) is designed to support interdisciplinary research teams of multiple PD/PIs to investigate the mechanism of action of pain relief by medical devices with the overall goal of optimizing therapeutic outcomes for FDA-approved or -cleared technologies. Program teams are expected to accomplish goals that require considerable synergy and collaborative interactions. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Teams are encouraged to consider objectives that will produce major advances in the field of pain relief by medical devices.

The Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) and the Division of Chemistry (CHE) are conducting a Re-entry to Active Research (RARE) program to reengage, retrain, and broaden participation within the academic workforce. The primary objective of the RARE program is to catalyze the advancement along the academic tenure-track of highly meritorious individuals who are returning from a hiatus from active research. By providing re-entry points to active academic research, the RARE program will reinvest in the nation’s most highly trained scientists and engineers, while broadening participation and increasing diversity of experience. A RARE research proposal must describe potentially transformative research that falls within the scope of participating CBET or CHEprograms. The RARE program includes two Tracks to catalyze the advancement of investigators along the academic tenure system after a research hiatus, either to a tenure-track position or to a higher-tenured academic rank. Track 1 of the RARE program reengages investigators in a competitive funding opportunity with accommodations for gap in record that are a result of the research hiatus. A Track 1 proposal will follow the budgetary guidelines of the relevant CBET program for an unsolicited research proposal or the relevant CHE Disciplinary Research program. Track 2 retrains investigators for whom the research hiatus has led to the need for new or updated techniques, such that retraining is required to return the investigator to competitive research activity. A description of how these new techniques will lead to competitive research in CBET or CHE programs is required. A Track 2 proposal budget will include only funds necessary for specific retraining activities, such as travel to a workshop or conference, workshop registration fees, a retraining sabbatical, or seed funding to support collection of preliminary data (including salary support, equipment usage fees, materials, and/or supplies). General inquiries regarding this program should be made to: [email protected] or a RARE Program Officer listed below.

This FOA seeks applications for unique and innovative recording and/or modulation technologies that are in the earliest stage of development, including new and untested ideas that are in the initial stages of conceptualization. Some projects may aim to increase recording or modulation capabilities by many orders of magnitude, while others may aim to improve the precision and selectivity of recording or modulation (also referred to as stimulation, perturbation, or manipulation). A wide range of modalities are appropriate including acoustic, chemical, electrical, magnetic, and optical, as well as the use of genetic tools. Invasive or non-invasive approaches are sought that will enable large-scale recording and/or precise manipulation of neural activity, and that would ultimately be compatible with experiments in humans or behaving animals. Applications are encouraged from any qualified individual, including chemists, physicists, engineers, theoreticians, materials scientists, and others from fields not typically involved with neuroscience research. This FOA requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.

The goal of this notice of funding opportunity (NOFO) is to support feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) for conditions that have been identified by NCCIH as high-priority research topics. This funding opportunity is intended to support feasibility clinical trials that provide new information that are scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent competitive full-scale clinical trial. Under this R34, the data collected should be used to fill gaps in scientific knowledge necessary to develop a competitive full-scale clinical trial, including, but not limited to the following: examining feasibility and acceptability of interventions lacking published data; tailoring or adapting the content or structure of an intervention to a specific population, modality, or setting; refining the intervention to determine the most appropriate frequency or duration; determining feasibility of recruitment, retention, and data collection procedures; refining and assessing the feasibility of protocolized multi-component interventions; or examining acceptability and adherence of control conditions. The subsequent full-scale clinical trial should have the potential to make a significant impact on public health. Prior to submitting to this NOFO, applicants are encouraged to contact the appropriate NCCIH Scientific/Research contact person for the science area of the planned application. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP).

The objectives of this RS&O FOA are to: (1) Strengthen nuclear science and engineering instruction in the curricula of colleges and universities that do not own research reactors (hereby referred to as “User Institutions”); (2) Increase opportunities for collaboration among faculty and students on nuclear science and engineering; (3) Improve community awareness and understanding of nuclear science, engineering, and technology through research reactor visits and other outreach opportunities; and (4) Engage with historically underrepresented communities in science, technology, engineering, and mathematics (STEM) to promote nuclear science, engineering, and technology to educate and recruit the next generation nuclear energy workforce.

This Notice of Funding Opportunity (NOFO) invites applications for specialized Alcohol Research Centers using the P50 mechanism. The overall purpose of the NIAAA Alcohol Research Center program is to provide leadership in conducting and fostering interdisciplinary, collaborative research on a wide variety of topics relevant to the Institutes mission. These topics include, but are not limited to: the nature, etiology, genetics, diagnosis, treatment, and prevention of alcohol use disorder, alcohol-related end-organ diseases and their biomedical, psychosocial, and economic consequences across the lifespan and racial/ethnic groups, and other health disparity populations. Centers also are regional or national resources that contribute to the development of new research methods, technologies, and approaches that sustain innovative goal-directed research.

With this solicitation, BJA is seeking applications to support DOJ’s Global Justice Information Sharing Initiative (Global) to engage the full range of criminal justice policymakers and practitioners in the development of innovative strategies to improve the justice information and criminal intelligence sharing and technology capabilities of state, local, Tribal, territorial agencies and associated disciplines.

Inspire! Grants for Small Museums is a special initiative of the Museums for America program. It is designed to support small museums of all disciplines in project-based efforts to serve the public through exhibitions, educational/interpretive programs, digital learning resources, policy development and institutional planning, technology enhancements, professional development, community outreach, audience development, and/or collections management, curation, care, and conservation. Inspire! has three project categories: - Lifelong Learning - Institutional Capacity - Collections Stewardship and Access

Reissue of PAR-18-431. NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention engages the target(s)/mechanisms(s) that is/are presumed to underlie the intervention effects; and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes. This FOA supports pilot effectiveness research to evaluate the feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches and inform the design of definitive effectiveness trials. Support for fully-powered, definitive effectiveness studies focused on post-acute phase interventions is provided via the R01 currently TEMP-11234.

The purpose of this concept is to facilitate the formation and maintenance of multidisciplinary research teams ready to employ epidemiological and/or etiological datasets and analyses to answer substance use prevention research questions and apply findings to intervention development or implementation. Projects supported through this concept will combine hands-on meeting formats, including both sandpit and hackathon approaches, with activities to sustain new research teams and networks, creating a foundational structure for research programs that have impact across disciplines.

The Family Unification Program (FUP) is a program under which public housing authorities (PHAs) that partner with public child welfare agencies (PCWAs) provide Housing Choice Voucher (HCV) assistance to two groups: 1. Families for whom the lack of adequate housing is a primary factor in the imminent placement of the family’s child, or children, in out-of-home care; or the delay in the discharge of the child, or children, to the family from out-of-home care; and 2. Youth at least 18 years and not more than 24 years of age (have not reached their 25th birthday) who left foster care, or will leave foster care within 90 days, in accordance with a transition plan described in Section 475(5)(H) of the Social Security Act, and are homeless or are at risk of becoming homeless at age 16 or older. There is no time limit on FUP vouchers issued to families. As required by statute, FUP vouchers issued to youth are limited to 36 months. The Fostering Stable Housing Opportunities (FSHO) amendments (Section 103 of Division Q of the Consolidated Appropriations Act, 2021 (Pub. L. 116-260)) provides FUP youth an extension of the 36-month time limit for up to an additional 24 months if they meet certain requirements. FSHO applies to FUP youth who first leased or leases a unit after the date of enactment of FSHO, December 27, 2020, which includes youth that will be assisted with funding under this NOFO. HUD published an FSHO implementation notice in the Federal Register on January 24, 2022 (87 FR 3570).

This Funding Opportunity Announcement (FOA) is a continuation of the NCI Mentored Research Scientist Development Award to Promote Diversity (K01) to enhance the diversity of thought in the NCI-funded cancer research workforce by supporting eligible individuals from diverse backgrounds, including groups that have been shown to be nationally underrepresented in the biomedical, behavioral, social and clinical sciences. This FOA provides salary and research support for a sustained period of "protected time" for intensive research career development under the guidance of an experienced mentor. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to the companion FOA

Materials Research is the field of science where physics, chemistry, materials science, and engineering naturally converge in the pursuit of the fundamental understanding of the properties of materials and the phenomena they host. Materials are abundant and pervasive, serving as critical building blocks in technology and innovation. Materials Research impacts life and society, as it shapes our understanding of the material world and enables significant advances spanning the range from nanoelectronics to health-related fields. The development and deployment of advanced materials are major drivers of U.S. economic growth. Research supported by the Division of Materials Research (DMR) focuses on advancing the fundamental understanding of materials, materials discovery, design, synthesis, characterization, properties, and materials-related phenomena. DMR awards enable understanding of the electronic, atomic, and molecular structures, mechanisms, and processes that govern nanoscale to macroscale morphology and properties; manipulation and control of these properties; discovery of emerging phenomena of matter and materials; and creation of novel design, synthesis, and processing strategies that lead to new materials with unique characteristics. These discoveries and advancements transcend traditional scientific and engineering disciplines. Projects supported by DMR are not only essential for the development of future technologies and industries that address societal needs, but also for the preparation of the next generation of materials researchers. Additional Information Eligibility rules apply for submissions; please see Section II. Program Description, Section IV. Eligibility Information, and Section V.A Proposal Preparation Instructions

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

The National Endowment for the Humanities (NEH) Division of Public Programs is accepting applications for the Media Projects program. This program supports collaboration between media producers and scholars to develop content grounded in humanities scholarship and prepare documentary films and television, radio programs, and podcasts that engage public audiences with humanities ideas in creative and appealing ways. NEH makes Media Projects awards at two levels: Development and Production.

The National Institute for Occupational Safety and Health (NIOSH) supports exploratory and developmental research projects (R21) that address issues related to diagnostic or treatment uncertainty with respect to individuals receiving monitoring and/or treatment under subtitle C of the James Zadroga 9/11 Health and Compensation Act of 2010.The Zadroga Act lists the following broad research areas:Physical and mental health conditions that may be related to the September 11, 2001, terrorist attacks;Diagnosing WTC-related health conditions for which there has been diagnostic uncertainty; andTreating WTC-related health conditions for which there has been treatment uncertainty.The WTC Health Program intends to increase opportunities for research on new, innovative approaches, interventions, techniques, or methodologies to improve treatment and diagnostic effectiveness through intervention, as well as support program evaluation.The WTC Health Program seeks to achieve a suitable mix of meritorious research projects which assess the feasibility of enhancing interventions and program evaluations to improve diagnosis, treatment, care, and well-being of 9/11-exposed populations.Research areas of interest include clinical, screening, diagnostic, epidemiological, treatment, prevention, translation, and program evaluation. WTC responders, screening-eligible WTC survivors, and certified-eligible WTC survivors comprise the population targeted for the research project.The research should consider health equity initiatives in design, where possible. Opportunities for future health effects research involving vulnerable groups of persons (e.g., minorities, women, children, and other potentially disadvantaged groups) who were exposed to the 9/11 attacks and aftermath are of special interest. Research is needed to identify at-risk groups, characterize the health burden, and inform care.This WTC Health Program R21 Notice of Funding Opportunity (NOFO) is intended to encourage exploratory/developmental research by providing support for the early and conceptual stages of project development which assess the feasibility of new areas of investigation with the potential to enhance treatment effectiveness and diagnostic practices. These studies may lead to breakthroughs in a particular area, or to the development of new interventions, techniques, agents, methodologies, models, or approaches with major clinical impacts. These studies are expected to break new ground or extend prior discoveries toward new directions or uses. Applicants are expected to propose research for which there is likely to be minimal or no preliminary data.The WTC Health Program Research webpage provides comprehensive information and tools for researchers. The research agenda, publication library, and other resources, including the Funding Dashboard, can also be found there (e.g., awarded project details such as publications, topics, populations, funding awarded, and the principal investigators and their institutions).

The Federal Transit Administration (FTA) announces the opportunity to apply for $9,169,076 in competitive grants for the Fiscal Year (FY) 2024 Public Transportation on Indian Reservations (Tribal Transit) Program under Assistance Listing Number 20.509.

This Funding Opportunity Announcement (FOA) invites applications from institutions proposing to develop, or renew, an Alzheimer's Disease Research Center (ADRC). The National Institute on Aging (NIA) funds ADRCs at major medical institutions across the United States. NIA-funded ADRCs serve as a national resource for research related to Alzheimers disease (AD) and AD-related dementias (ADRD). Additionally, ADRCs work to translate research advances into improved diagnosis and care, as well as find ways to treat, and possibly prevent, AD/ADRD. Lastly, ADRCs collaborate and coordinate their research efforts with other programs and investigators funded by the National Institutes of Health (NIH).

This NOFO invites applications that propose the comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer's Disease-Related Dementias (ADRDs). This NOFO seeks to promote critical target validation approaches to help de-risk subsequent translational research and accelerate the advancement of novel therapies for ADRD. Target(s) or molecular pathway(s) to be considered for validation must have been already identified using tissue expression or genetic data generated in human samples. In its initial phase, this FOA provided support for up to two years (R61 stage) for the development of customized technologies, models, and protocols to modulate the expression or activity of target candidate(s) in cells or tissues and monitor their functional biological consequences in in vitro or in vivo disease models. Upon demonstration of technical feasibilities, a second phase (R33 stage) will carefully and reproducibly measure and cross-validate the impact of the target modulation in different modalities across collaborating laboratories using the NIH rigor and reproducibility guidelines. Applicants responding to this NOFO must address objectives for both the R61 and R33 phases and are expected to have a substantial collaborative effort between independents laboratories. This NOFO is not specific for any one or group within the ADRD spectrum of disorders. Disorders covered in these applications are frontotemporal degeneration (FTD), Lewy body dementias (LBD) (including dementia with Lewy bodies (DLB)), Parkinson disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), mixed dementias including the associated diagnostic challenges of multiples etiology dementias (MED).

The National Institutes of Health (NIH) will award Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) to eligible, domestic institutions to develop and/or enhance predoctoral and postdoctoral research training, including short-term research training, to help ensure that a diverse and highly trained workforce is available to meet the needs of the Nations biomedical, behavioral, and clinical research agenda. Research training programs are expected to incorporate engaging, didactic, research, and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation. Programs proposing only short-term predoctoral research training should not apply to this announcement, but rather to the Kirschstein-NRSA Short-Term Institutional Research Training Grant Program (T35) exclusively reserved for predoctoral, short-term research training. This Funding Opportunity Announcement (FOA) does not allow appointed Trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

The NIDCR Small Grant Program for New Investigators (R03) supports basic and clinical research conducted by scientists who are in the early stages of establishing an independent research career in oral, dental and craniofacial research. This program supports pilot or feasibility studies and developmental research projects with the intention of obtaining sufficient preliminary data for a subsequent investigator-initiated Research Project Grant (R01) or equivalent application.

This Notice of Funding Opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials related to the research mission of the NIAID. This program provides support for hypothesis-driven, milestone-driven clinical trials. Although clinical trials not considered high-risk may be proposed, this program encourages high-risk clinical studies. High- risk does not imply human subject or patient risk, but rather defines a study that contains one or more of the following unique features: involves non-routine interventions, administration of an unlicensed product, or administration of a licensed product for an unapproved indication. Mechanistic studies are also encouraged and may be proposed under this program.

The 21st Century Museum Professional (21MP) grant program supports projects that offer professional development to the current museum workforce, train and recruit future museum professionals, and identify and share effective practices in museum workforce education and training. IMLS recognizes the important role of strong local and regional networks in providing peer-to-peer learning, training, and mentoring opportunities for the museum workforce. Partnerships among museums, museum-serving organizations, and institutions of higher education are vital to expanding career pathways for broad groups of museum professionals throughout a city, county, state, region, or the nation. The 21MP Program encourages applications from museum associations, museum studies programs at institutions of higher education, and museums that serve as essential parts of the professional learning and training environment.

The purpose of this funding opportunity announcement is to encourage collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science.

This Funding Opportunity Announcement (FOA) solicits applications investigating the biology and underlying mechanisms of bladder cancer. Bladder cancer is a significant health problem both in the United States and globally. Because of the high incidence and frequent tumor recurrence, bladder cancer exacts an outsized medical burden. While recent progress has been made in the molecular profiling of bladder cancers and identification of mutated genes, relatively little is known regarding the molecular mechanisms driving initiation, progression, and malignancy of bladder cancer. Furthermore, our understanding of biological processes of the normal bladder at the molecular, cell and organ levels is limited. Fundamental knowledge of how molecular and cellular functions of the bladder are altered in cancer will aid our understanding of bladder cancer biology and interventions. Applications that involve multidisciplinary teams and use clinical specimens or investigate both normal and cancer processes are encouraged.

The National Human Genome Research Institute (NHGRI) will renew the Human Genome Reference Program (HGRP). This Informatics Tools for the Pangenome FOA will provide multiple awards to develop informatics tools that enable uptake and use of the improved pangenome reference. Emphasis will be on tools for common use cases that are relevant to different broad sectors of the genomics community, e.g., clinical, population, and functional genomics. Possible examples include selecting the best subset of linear genomes or paths along the graph for a given set of samples, visualizing complex variation, and annotating regulatory elements and disease associations.

The Population Assessment of Tobacco and Health (PATH) Study provides the scientific community with biospecimens (urine, plasma, serum, and genomic DNA) and related research data on behaviors, attitudes, biomarkers and health outcomes associated with tobacco use in the U.S. This opportunity allows investigators to apply for access to the biospecimens from the PATH Study. Information about the PATH Study and this resource may be found on the PATH Study series page (https://doi.org/10.3886/Series606) at the University of Michigans National Addiction and HIV Data Archive Program (NAHDAP) website, part of the Inter-University Consortium for Political and Social Researchs (ICPSR) website.

Fiscal Year 2024 Flood Mitigation Assistance (FMA) Swift Current aims to better align the delivery of FMA flood mitigation funding to the disaster survivor experience. The purpose of FMA Swift Current is to reduce or eliminate the flood risk to NFIP-participating communities and repetitive flood damage to structures and buildings insured by the NFIP following a flood-related disaster event, and to enhance community flood resilience within NFIP-participating communities. It does so by providing funding for mitigation opportunities immediately after a flood disaster event with the aim of delivering mitigation outcomes.   | Swift Current is a grant opportunity under the FMA grant program. The FMA grant program makes federal funds available to states, U.S. territories, federally recognized tribal governments, and local governments to reduce or eliminate the risk of repetitive flood damage to buildings and structures insured under the National Flood Insurance Program (NFIP), and within NFIP-participating communities. It does so with a recognition of the growing flood hazards associated with climate change, and of the need for flood hazard risk mitigation activities that promote climate adaptation, equity, and resilience with respect to flooding. These include both acute extreme weather events and chronic stressors which have been observed and are expected to increase in intensity and frequency in the future. | Projects or initiatives that are eligible for funding under this announcement may or may not involve Geospatial (GIS) issues. | Applicants can submit applications for this funding opportunity through FEMA Grants Outcomes (GO). Access the system at https://go.fema.gov/

The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-21-293). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

The purpose of this reissuance is to seek research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to enhance workforce diversity in the research workforce and maintain a strong cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the pool of diverse and independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, an ancillary clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion FOA (RFA-NS-22-025).

The Incorporating Human Behavior in Epidemiological Models (IHBEM) Program supports research that incorporates research on social and behavioral processes in mathematical epidemiological models.The program provides support for projects that involve balanced participation from the mathematical sciences and from the social, behavioral, and economic sciences.

1.The Centers of Excellence in Genomic Science (CEGS) program establishes academic Centers for advanced genome research. Each CEGS award supports a multi-investigator, interdisciplinary team to develop integrated, transformative genomic approaches to address a biomedical problem. A CEGS project will address a critical issue in genomic science, genomic medicine, or computational genomics, proposing a highly innovative solution that would be a major advance. The research will entail substantial risk, balanced by outstanding scientific and management plans and very high potential payoff. A CEGS will focus on the development of novel technological or computational methods for the production or analysis of comprehensive data sets, on a genome-scale biomedical problem, or on other ways to develop and use genomic approaches for understanding biological systems or furthering the application of genomic knowledge, data, and methods towards clinical applications. Each CEGS will nurture genomics by facilitating the interaction of investigators from several disciplines. Along with its scientific goals, CEGS will also expand the pool of genomic scientists and engineers that can use and apply the novel methods, concepts, and knowledge developed by the CEGS by providing education and outreach experiences to scientists at all career levels.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for investigator-initiated Program Project (P01) applications. The proposed Program may address any of the broad areas of cancer research, including (but not limited to) cancer biology, cancer prevention, cancer diagnosis, cancer treatment, and cancer control. Basic, translational, clinical, and/or population-based studies in all of these research areas are appropriate. Each application submitted in response to this FOA must consist of at least three research projects and an Administrative Core. The projects must share a common central theme, focus, and/or overall objective.

This NOFO uses the NIH Comprehensive Research Center (P60) mechanism to support an integrated, broad-based multidisciplinary, multi-investigator, long-term program of research and research support activities planned around a specific major research theme.

The Long Term Research in Environmental Biology (LTREB) Program supports the generation of extended time series of data to address important questions in evolutionary biology, ecology, and ecosystem science. Research areas include, but are not limited to, the effects of natural selection or other evolutionary processes on populations, communities, or ecosystems; the effects of interspecific interactions that vary over time and space; population or community dynamics for organisms that have extended life spans and long turnover times; feedbacks between ecological and evolutionary processes; pools of materials such as nutrients in soils that turn over at intermediate to longer time scales; and external forcing functions such as climatic cycles that operate over long return intervals. All proposals submitted through the LTREB solicitation are processed by 1 of the 3 clusters in the Division of Environmental Biology: Ecosystem Science, Population and Community Ecology, and Evolutionary Processes. Proposals must address topics supported by these clusters. Researchers who are uncertain about the suitability of their project for the LTREB Program are encouraged to contact the cognizant Program Officer. Ecological research on marine populations, communities and ecosystems is not supported by LTREB and should be directed to the Biological Oceanography Program: (https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=11696&org=OCE). However, research that examines the evolutionary dynamics of marine populations or communities will be accepted. Investigators who are uncertain about the suitability of their research for LTREB are strongly encouraged to contact the managing Program Officers listed in this solicitation. Examples of current LTREB awards can be viewed at https://www.nsf.gov/awardsearch/ by including 'LTREB' in a title search. The Program intends to support decadal projects. Funding for an initial, 5-year period requires submission of a proposal that includes a 15-page project description containingtwo essential components: a decadal research plan and a description of core data. Proposals for the second five years of support (renewal proposals) are limited to a ten-page project description. Continuation of an LTREB project beyond an initial ten-year award will require submission of a new proposal that presents a new decadal research plan. Specific review criteria for LTREB proposals and renewals are explained within this solicitation. Prospective proposers are advised to read this solicitation carefully.

The purpose of this Notice of Funding Opportunity (NOFO) is to seek health services research grant applications focused on AHRQ research priorities, including improving healthcare quality and patient safety, improving healthcare delivery and practice improvement, and enhancing whole-person healthcare delivery. AHRQ supports research in all healthcare settings, including the hospital, long-term care, ambulatory care, home healthcare, pharmacy, and care transitions between settings. Research may involve many partners and other groups, including patients, families, clinicians, non-clinical healthcare staff, policymakers, payers, healthcare organizations, providers and accreditors, local and State governments, the Federal Government, and others.

This initiative will support projects that focus solely on development of technologies with the potential to enable acquisition of basic biomedical knowledge. Projects should be justified in terms of technical innovation, and utility for future biomedical impact.The products of this research will be functioning prototype instruments, methods, synthetic approaches, biological products, etc., characterized adequately to be ready for first application to the type of biomedical research questions that provide the rationale for their development, but application of the proposed technology to specific biomedical questions is considered beyond the scope of the program, should not be included, and would not be funded.Proof of principle for the technology will have already been shown, but there will still be significant fundamental technical challenges. Applications should include preliminary data. Projects that have significant remaining risk but are supported by early feasibility studies might be appropriate for a three year R01 proposal with reduced budget to better manage risk and investment. Projects that are well supported by feasibility studies and propose to develop fully functional prototypes might require higher budgets and a four year duration (five years for early stage investigators). Projects that primarily focus on optimization, hardening, or obvious extrapolations of established technology might be less competitive.

This USAID/Sahel Regional Office (SRO) RFI is issued for the purpose of providing  stakeholders an opportunity to review, comment, suggest, and enhance areas in the attached draft design document  for a new USAID/Sahel Regional Office activity: the Resilient Governance in Niger activity (RGN). RGN is expected to be an $18,000,000, three-year activity, with two option years for a total of five years, subject to the availability of funds. | RGN will serve leading governance activity in Niger under the USAID’s Resilience in the Sahel II Project (RISE II). RGN will address Objective 4: Enhance governance of institutions and organizations, of the RISE II results framework (attached), specifically sub-IR 4.1: Improved performance of sub-national state institutions and sub-IR 4.2: Strengthened local civil society and community based organizations. The Activity is intended to support locally-driven, politically feasible approaches to enhance: | Municipal government and citizen understanding of the roles and responsibilities of municipal governments and deconcentrated national authorities, and intergovernmental communications concerning local governance; Planning, budgeting and administrative capacity of municipal governments to manage and mobilize financial and human resources for locally-determined service and infrastructure needs; and Civic engagement in communal governance - in determining local priorities, and in holding government accountable to meet its obligations  USAID has revised its program cycle guidance to facilitate more adaptive, contextually-driven programming approaches, and the choice of a high-level, objective-oriented  design rather than a more prescriptive scope reflects this. The attached draft presents RGN’s proposed objectives and expected outcomes. USAID/Sahel Regional Office may significantly revise this proposed new activity and planned solicitation resulting from the comments received, and from further stakeholder consultations. This RFI is issued solely for information and planning purposes and does not constitute a Request for Applications or Proposals (RFA/RFP). Responses to this RFI shall not be portrayed as proposals and will not be accepted by the U.S. Government (USG) to form a binding agreement. This RFI is not to be construed as a commitment by the USG to issue any solicitation or ultimately award of an assistance agreement or contract on the basis of this RFI, or to pay for any information submitted as a result of this request. Responders are solely responsible for all expenses associated with responding to this RFI. USAID reserves the right to modify the scope and scale of the RFI (following the pre-solicitation conference). | It should be noted that responding to or providing comment on this RFI will not give any advantage to any organization in any subsequent procurement. USAID/Sahel Regional Office will not provide answers to any question submitted in response to this request. | By issuing the draft for comment, USAID/Sahel Regional Office aims to consult with a broad community of public and private sector actors concerned with improving governance and service delivery in Niger. Your comments are requested to help refine the draft design document to ensure clarity, maximum development impact, coordination with existing and planned USAID and other development partner programs, and alignment with the Government of Niger’s priorities. | Please provide no more than four  (4) pages of comments no later than December 24, 2018 via email to [email protected]. While the limit on the length of submissions is four pages, we value concise, issue-specific comments with reference to page and section numbers in the draft design document. You may receive an electronic confirmation acknowledging receipt of your response.   | USAID seeks feedback in particular on the following questions: | 1)   Are the Activity theory of change and expected outcomes clear and realistic? 2) Does the program description provide potential implementers with sufficient information and guidance about USAID/SRO’s objectives and expectations?3) RGN is intended to embody principles of flexible, adaptive management and context-driven, locally-owned approaches to systems change. What suggestions do you have for how to ensure this is well-reflected in a solicitation/notice of funding opportunity? USAID will hold a Pre-Solicitation Conference on Wednesday December 19, 2018 at the U.S. Embassy in Dakar from 14:30 to 17:00 local time (GMT). For convenience, participation through webinar will be provided. | Organizations may send up to two (2) participants to the conference in-person. Additionally, others may connect remotely. | To facilitate better planning, please RSVP your attendance by filling-in the registration form no later than December 12, 2018 indicating whether you will participate in-person in Dakar, or call in remotely. Link for registration form:   | https://goo.gl/forms/IjVTjZu764kWwRsF3  We will send you the remote connection information once we receive the RSVP. | |

MCB supports research that promises to uncover the fundamental properties of living systems across atomic, molecular, subcellular, and cellular scales. The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, subcellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB encourages research exploring new concepts in molecular and cellular biology, while incorporating insights and approaches from other scientific disciplines, such as chemistry, computer science, engineering, mathematics, and physics, to illuminate principles that govern life at the molecular and cellular level. MCB also encourages research that exploits experimental and theoretical approaches and utilizes a diverse spectrum of model and non-model animals, plants, and microbes across the tree of life. Proposals that pursue potentially transformative ideas are welcome, even if these entail higher risk. This solicitation calls for proposals in research areas supported by the four MCB core clusters, including: (i) structure, dynamics, and function of biomolecules and supramolecular assemblies, especially under physiological conditions (Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information (Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales (Cellular Dynamics and Function); and (iv) systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale (Systems and Synthetic Biology). All MCB clusters prioritize projects that integrate across scales, investigate molecular and cellular evolution, synergize experimental research with computational or mathematical modeling, and/or develop innovative, broadly applicable methods and technologies. Projects that bridge the intellectual edges between MCB clusters are welcome. Projects that integrate molecular and cellular biosciences with other subdisciplines of biology are also welcome through the new Integrative Research in Biology (IntBIO) track. All programs in the Directorate for Biological Sciences striveto achieve key goals laid out in the NSF Strategic Plan. Among these goals are: (i) to empower Science Technology, Engineering, and Mathematics (STEM) talent to fully participate in science and engineering; (ii) to enable creation of new knowledge by advancing the frontiers of research and enhancing research capability; and (iii) to benefit society through translation of knowledge into solutions. In line with these goals, MCB welcomes the submission of proposals to this funding opportunity that include the participation of the full spectrum of diverse talent in STEM, e.g., as PI, co-PI, senior personnel, postdoctoral scholars, graduate or undergraduate students or trainees.  This includes historically under-represented or underserved populations, diverse institutions including Minority Serving Institutions (MSIs), Primarily Undergraduate Institutions (PUIs), and two-year colleges, as well as major research institutions. Proposals from EPSCoR jurisdictions are especially encouraged.MCB has a new track in this solicitation, EXPAND MCB in EPSCoR, that welcomes proposals that build capacity through collaborations led by organizations in EPSCoR jurisdictions. Also aligned with the NSF Strategic Plan, MCB encourages submission of proposals in support of discovery-based explorations, as well as use-inspired, solutions-focused research, including proposals that address priority areas associated with building a resilient planet and biotechnology and the bioeconomy. Some examples of topics that address priority areas associated with building a resilient planet and biotechnology and the bioeconomy can be found in the life on a warming planet and bioeconomy metaprogram descriptions. The CHIPs Act of 2022 and the Executive Order on Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe and Secure American Bioeconomy highlight the importance of these two areas with respect to safeguarding national security and promoting prosperity. MCB also strongly encourages proposals that leverage NSF resources to facilitate integration across the biological sciences, such as the National Ecological Observatory Network (NEON), data networks, synthesis centers, and institutes. Regarding health-related challenges, NSF supports basic research in all areas of the biological sciences and recognizes that this foundational research is likely to impact many different areas, including human health. MCB celebrates all the biological science discoveries funded through MCB awards that have had major impacts on health, environment, energy, food production, and other applications. Nevertheless, research focused exclusively on understanding human diseases and their treatment is normally outside of the scope offunding and will be returned without review unless that research significantly advances other fields such as engineering, computer science, or the mathematical and physical sciences.

The FOA seeks to expand the HIV/AIDS prevention toolkit among alcohol impacted populations with a range of patterns of episodic and long-term use and associated behavioral and biological risks for HIV acquisition. This includes integration of effective prevention and treatment interventions with an understanding of the overarching framework for reducing the incidence of new infections by facilitating cross-cutting informative research. This R34 Funding Opportunity Announcement (FOA) supports studies that are both necessary and sufficient to inform the planning of a clinical trial within the scope of the companion announcement HIV Prevention and Alcohol (R01 Clinical Trials Optional). The NIAAA expects that applications to this FOA will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this FOA will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention of HIV. In this NIAAA funding opportunity for pilot clinical trials the R34 mechanism is intended to provide new information that answers a scientific or operational question(s) which may be pragmatic in nature and, therefore, informs the final development of a clinical trial and testing of intervention tools.